Integrin subunit beta like 1

ITGBL1
Identifiers
Aliases	ITGBL1 , OSCP, TIED, integrin subunit beta like 1
External IDs	OMIM: 604234 MGI: 2443439 HomoloGene: 3519 GeneCards: ITGBL1
Gene location (Human)
Chr.	Chromosome 13 (human)
End	101,720,856 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	124,213,030 bp
RNA expression pattern
	Top expressed in
	frontal pole; ; middle frontal gyrus; ; ascending aorta; ; Achilles tendon; ; pericardium; ; synovial joint; ; right coronary artery; ; popliteal artery; ; visceral pleura; ; synovial membrane;
	Top expressed in
	calvaria; ; sciatic nerve; ; ascending aorta; ; aortic valve; ; interventricular septum; ; utricle; ; ankle; ; body of femur; ; cornea; ; intercostal muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	integrin binding ;
Cellular component	extracellular region ; plasma membrane ; focal adhesion ; integrin complex ; cell surface ;
Biological process	cell adhesion ; cell-matrix adhesion ; integrin-mediated signaling pathway ; cell migration ; cell adhesion mediated by integrin ;
	Sources:Amigo / QuickGO
Orthologs
	9358
	223272
	ENSG00000198542
	ENSMUSG00000032925
	O95965
	Q8VDV0
	NM_001271754 ; NM_001271755 ; NM_001271756 ; NM_004791
	NM_145467
	NP_001258683 ; NP_001258684 ; NP_001258685 ; NP_004782
	NP_663442
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated June 16, 2023

Integrin subunit beta like 1 is a protein that in humans is encoded by the ITGBL1 gene. ^[5]

Function

This gene encodes a beta integrin-related protein that is a member of the EGF-like protein family. The encoded protein contains integrin-like cysteine-rich repeats. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012].

Related Research Articles

CD11c, also known as Integrin, alpha X (ITGAX), is a gene that encodes for CD11c.

Integrin beta-1 (ITGB1), also known as CD29, is a cell surface receptor that in humans is encoded by the ITGB1 gene. This integrin associates with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors. It also forms dimers with integrin alpha 3 to form integrin receptors for netrin 1 and reelin. These and other integrin beta 1 complexes have been historically known as very late activation (VLA) antigens.

CD49d is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor.

Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin.

Caveolin-1 is a protein that in humans is encoded by the CAV1 gene.

Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene.

Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene.

Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.

Integrin, beta 4 (ITGB4) also known as CD104, is a human gene.

Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene.

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform is an enzyme that in humans is encoded by the PPP2R1B gene.

Krueppel-like factor 11 is a protein that in humans is encoded by the KLF11 gene.

Tetraspanin-7 is a protein that in humans is encoded by the TSPAN7 gene.

Four and a half LIM domains protein 3 is a protein that in humans is encoded by the FHL3 gene.

Integrin alpha-9 is a protein that in humans is encoded by the ITGA9 gene. Cytogenetic location: 3p22.2

Integrin alpha-D is a protein that in humans is encoded by the ITGAD gene.

Integrin alpha-11 is a protein that, in humans, is encoded by the ITGA11 gene.

Ancient ubiquitous protein 1 is a protein that in humans is encoded by the AUP1 gene.

Integrin alpha-10 also known as ITGA10 is a protein that in humans is encoded by the ITGA10 gene.

Dual specificity protein phosphatase 23, also known as low molecular mass dual specificity phosphatase 3 (LDP-3), is an enzyme that in humans is encoded by the DUSP23 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198542 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032925 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Integrin subunit beta like 1" . Retrieved 2018-07-18.

Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C (August 2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling". Gut. 58 (8): 1078–83. doi:10.1136/gut.2008.169052. PMID 19240061. S2CID 17111427.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832 . PMID 19913121.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168 . PMID 20628086.
Li XQ, Du X, Li DM, Kong PZ, Sun Y, Liu PF, Wang QS, Feng YM (August 2015). "ITGBL1 Is a Runx2 Transcriptional Target and Promotes Breast Cancer Bone Metastasis by Activating the TGFβ Signaling Pathway". Cancer Res. 75 (16): 3302–13. doi: 10.1158/0008-5472.CAN-15-0240 . PMID 26060017.
Gan X, Liu Z, Tong B, Zhou J (February 2016). "Epigenetic downregulated ITGBL1 promotes non-small cell lung cancer cell invasion through Wnt/PCP signaling". Tumour Biol. 37 (2): 1663–9. doi:10.1007/s13277-015-3919-8. PMID 26307393. S2CID 54485581.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198542 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032925 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Integrin subunit beta like 1" . Retrieved 2018-07-18.

[1]

[2]

[3]

[4]

[5]

Integrin subunit beta like 1

Contents

Function

Related Research Articles

References

Further reading