Intelectin-1

ITLN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4WMQ, 4WMY
Identifiers
Aliases	ITLN1 , HL-1, HL1, INTL, ITLN, LFR, hIntL, omentin, intelectin 1
External IDs	OMIM: 609873 MGI: 1333831 HomoloGene: 111044 GeneCards: ITLN1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	160,885,180 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	171,362,862 bp
RNA expression pattern
	Top expressed in
	parietal pleura; ; pericardium; ; germinal epithelium; ; rectum; ; jejunal mucosa; ; duodenum; ; right coronary artery; ; vena cava; ; popliteal artery; ; appendix;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; Paneth cell; ; duodenum; ; jejunum; ; intestinal villus; ; ileum; ; cervix; ; left colon; ; gastric mucosa; ; esophagus;
	More reference expression data
	n/a
Gene ontology
Molecular function	carbohydrate binding ; calcium ion binding ; oligosaccharide binding ; metal ion binding ; identical protein binding ;
Cellular component	membrane raft ; anchored component of membrane ; brush border membrane ; receptor complex ; plasma membrane ; extracellular exosome ; membrane ; extracellular region ;
Biological process	positive regulation of glucose import ; positive regulation of protein phosphorylation ; response to nematode ; antimicrobial humoral response ; protein homotrimerization ;
	Sources:Amigo / QuickGO
Orthologs
	55600
	16429
	ENSG00000179914
	ENSMUSG00000038209
	Q8WWA0
	O88310
	NM_017625
	NM_010584
	NP_060095
	NP_034714
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 29, 2023

Intelectin-1, also known as omentin or intestinal lactoferrin receptor, is an intelectin encoded in humans by the ITLN1 gene.^[5]^[6]^[7] Intelectin-1 functions both as a receptor for bacterial arabinogalactans ^[5] and for lactoferrin.^[8]

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Intelectins are lectins expressed in humans and other chordates. Humans express two types of intelectins encoded by ITLN1 and ITLN2 genes respectively. Several intelectins bind microbe-specific carbohydrate residues. Therefore, intelectins have been proposed to function as immune lectins. Even though intelectins contain fibrinogen-like domain found in the ficolins family of immune lectins, there is significant structural divergence. Thus, intelectins may not function through the same lectin-complement pathway. Most intelectins are still poorly characterized and they may have diverse biological roles. Human intelectin-1 (hIntL-1) has also been shown to bind lactoferrin, but the functional consequence has yet to be elucidated. Additionally, hIntL-1 is a major component of asthmatic mucus and may be involved in insulin physiology as well.

Intelectin 2 is a protein that in humans is encoded by the ITLN2 gene.

Collectin-12, also known as collectin subfamily member 12, is a collectin protein that in humans is encoded by the COLEC12 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000179914 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038209 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Tsuji S, Uehori J, Matsumoto M, Suzuki Y, Matsuhisa A, Toyoshima K, Seya T (June 2001). "Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall". The Journal of Biological Chemistry. 276 (26): 23456–63. doi: 10.1074/jbc.M103162200 . PMID 11313366.
↑ Lee JK, Schnee J, Pang M, Wolfert M, Baum LG, Moremen KW, Pierce M (January 2001). "Human homologs of the Xenopus oocyte cortical granule lectin XL35". Glycobiology. 11 (1): 65–73. doi: 10.1093/glycob/11.1.65 . PMID 11181563.
↑ "Entrez Gene: ITLN1 intelectin 1 (galactofuranose binding)".
↑ Suzuki YA, Shin K, Lönnerdal B (December 2001). "Molecular cloning and functional expression of a human intestinal lactoferrin receptor". Biochemistry. 40 (51): 15771–9. doi:10.1021/bi0155899. PMID 11747454.
↑ Wesener DA, Wangkanont K, McBride R, Song X, Kraft MB, Hodges HL, Zarling LC, Splain RA, Smith DF, Cummings RD, Paulson JC, Forest KT, Kiessling LL (August 2015). "Recognition of microbial glycans by human intelectin-1". Nature Structural & Molecular Biology. 22 (8): 603–10. doi:10.1038/nsmb.3053. PMC 4526365 . PMID 26148048.
↑ Wangkanont K, Wesener DA, Vidani JA, Kiessling LL, Forest KT (March 2016). "Structures of Xenopus Embryonic Epidermal Lectin Reveal a Conserved Mechanism of Microbial Glycan Recognition". The Journal of Biological Chemistry. 291 (11): 5596–610. doi: 10.1074/jbc.M115.709212 . PMC 4786701 . PMID 26755729.

Suzuki YA, Lopez V, Lönnerdal B (November 2005). "Mammalian lactoferrin receptors: structure and function". Cellular and Molecular Life Sciences. 62 (22): 2560–75. doi:10.1007/s00018-005-5371-1. PMID 16261254. S2CID 265994535.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Chang BY, Peavy TR, Wardrip NJ, Hedrick JL (January 2004). "The Xenopus laevis cortical granule lectin: cDNA cloning, developmental expression, and identification of the eglectin family of lectins". Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology. 137 (1): 115–29. doi:10.1016/S1095-6433(03)00269-1. PMID 14720597.
Wali A, Morin PJ, Hough CD, Lonardo F, Seya T, Carbone M, Pass HI (April 2005). "Identification of intelectin overexpression in malignant pleural mesothelioma by serial analysis of gene expression (SAGE)". Lung Cancer. 48 (1): 19–29. doi:10.1016/j.lungcan.2004.10.011. PMID 15777968.
Schäffler A, Neumeier M, Herfarth H, Fürst A, Schölmerich J, Büchler C (December 2005). "Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1732 (1–3): 96–102. doi:10.1016/j.bbaexp.2005.11.005. PMID 16386808.
Yang RZ, Lee MJ, Hu H, Pray J, Wu HB, Hansen BC, Shuldiner AR, Fried SK, McLenithan JC, Gong DW (June 2006). "Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action". American Journal of Physiology. Endocrinology and Metabolism. 290 (6): E1253-61. doi:10.1152/ajpendo.00572.2004. PMID 16531507.
Schäffler A, Zeitoun M, Wobser H, Buechler C, Aslanidis C, Herfarth H (February 2007). "Frequency and significance of the novel single nucleotide missense polymorphism Val109Asp in the human gene encoding omentin in Caucasian patients with type 2 diabetes mellitus or chronic inflammatory bowel diseases". Cardiovascular Diabetology. 6: 3. doi: 10.1186/1475-2840-6-3 . PMC 1802733 . PMID 17295929.
Wurm S, Neumeier M, Weigert J, Schäffler A, Buechler C (February 2007). "Plasma levels of leptin, omentin, collagenous repeat-containing sequence of 26-kDa protein (CORS-26) and adiponectin before and after oral glucose uptake in slim adults". Cardiovascular Diabetology. 6: 7. doi: 10.1186/1475-2840-6-7 . PMC 1804262 . PMID 17311679.
de Souza Batista CM, Yang RZ, Lee MJ, Glynn NM, Yu DZ, Pray J, Ndubuizu K, Patil S, Schwartz A, Kligman M, Fried SK, Gong DW, Shuldiner AR, Pollin TI, McLenithan JC (June 2007). "Omentin plasma levels and gene expression are decreased in obesity". Diabetes. 56 (6): 1655–61. doi: 10.2337/db06-1506 . PMID 17329619.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000179914 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038209 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11313366-5] 1 2 Tsuji S, Uehori J, Matsumoto M, Suzuki Y, Matsuhisa A, Toyoshima K, Seya T (June 2001). "Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall". The Journal of Biological Chemistry. 276 (26): 23456–63. doi: 10.1074/jbc.M103162200 . PMID 11313366.

[pmid11181563-6] Lee JK, Schnee J, Pang M, Wolfert M, Baum LG, Moremen KW, Pierce M (January 2001). "Human homologs of the Xenopus oocyte cortical granule lectin XL35". Glycobiology. 11 (1): 65–73. doi: 10.1093/glycob/11.1.65 . PMID 11181563.

[entrez-7] "Entrez Gene: ITLN1 intelectin 1 (galactofuranose binding)".

[pmid11747454-8] Suzuki YA, Shin K, Lönnerdal B (December 2001). "Molecular cloning and functional expression of a human intestinal lactoferrin receptor". Biochemistry. 40 (51): 15771–9. doi:10.1021/bi0155899. PMID 11747454.

[9] Wesener DA, Wangkanont K, McBride R, Song X, Kraft MB, Hodges HL, Zarling LC, Splain RA, Smith DF, Cummings RD, Paulson JC, Forest KT, Kiessling LL (August 2015). "Recognition of microbial glycans by human intelectin-1". Nature Structural & Molecular Biology. 22 (8): 603–10. doi:10.1038/nsmb.3053. PMC 4526365 . PMID 26148048.

[10] Wangkanont K, Wesener DA, Vidani JA, Kiessling LL, Forest KT (March 2016). "Structures of Xenopus Embryonic Epidermal Lectin Reveal a Conserved Mechanism of Microbial Glycan Recognition". The Journal of Biological Chemistry. 291 (11): 5596–610. doi: 10.1074/jbc.M115.709212 . PMC 4786701 . PMID 26755729.

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Intelectin-1

Contents

See also

Related Research Articles

References

Further reading