U.S. Route 14, an east–west route, is one of the original United States highways of 1926. It currently has a length of 1,398 miles (2,250 km), but it had a peak length of 1,429 miles (2,300 km). For much of its length, it runs roughly parallel to Interstate 90.
U.S. Route 400 is a 481.306-mile-long (774.587 km) mostly east–west U.S. Highway, commissioned in 1994. The highway's western terminus is in Granada, Colorado, at an intersection with US 385. The highway's eastern terminus is southwest of Joplin, Missouri, near Loma Linda, at an interchange with Interstate 44, with which it shares with US 166. It originally ended in Garden City, Kansas; in 1996 it was extended to its current western terminus.
U.S. Route 69 (US 69) is a major north–south United States highway. When it was first created, it was only 150 miles (241 km) long, but it has since been expanded into a Minnesota to Texas cross-country route. The highway's southern terminus is in Port Arthur, Texas at an intersection with State Highway 87. Its northern terminus is in Albert Lea, Minnesota at Minnesota State Highway 13.
U.S. Route 160 (US 160) is a 1,465 mile (2,358 km) long east–west United States highway in the Midwestern and Western United States. The western terminus of the route is at US 89 five miles (8 km) west of Tuba City, Arizona. The eastern terminus is at US 67 and Missouri 158 southwest of Poplar Bluff, Missouri. Its route, if not its number, was made famous in song in 1975, as the road from Wolf Creek Pass to Pagosa Springs, Colorado in C.W. McCall's country music song Wolf Creek Pass.
U.S. Route 52 (US 52) is a major United States highway in the central United States that extends from the northern to southeastern region of the United States. Contrary to most other even-numbered U.S. Highways, US 52 primarily follows a northwest–southeast route, and is signed north–south or east–west depending on the local orientation of the route. The highway's northwestern terminus is at Portal, North Dakota, on the Canadian border, where it continues as Saskatchewan Highway 39. Its southeastern terminus is in Charleston, South Carolina, at Number 2 Meeting Street and White Point Garden along the Charleston Harbor.
U.S. Route 71 or U.S. Highway 71 is a major north–south United States highway that extends for over 1500 miles (2500 km) in the central United States. This original 1926 route has remained largely unchanged by encroaching Interstate highways. Currently, the highway's northern terminus is in International Falls, Minnesota at the Canada–US border, at the southern end of the Fort Frances-International Falls International Bridge to Fort Frances, Ontario. U.S. Route 53 also ends here. On the other side of the bridge, Trans-Canada Highway is an east–west route while Highway 71 is a north–south route. US 71's southern terminus is between Port Barre and Krotz Springs, Louisiana at an intersection with U.S. Route 190. For the entirety south of Kansas City, Missouri, US 71 runs parallel and concurrent with the existing and future Interstate 49. North of Kansas City, US 71 runs halfway between Interstate 29 and Interstate 35, which they split in the city at an interchange with Interstate 70.
U.S. Route 18 is an east–west U.S. highway in the Midwestern United States. The western terminus is in Orin, Wyoming at an interchange with Interstate 25. Its eastern terminus is in downtown Milwaukee, Wisconsin. However, US 18 runs concurrent with other U.S. routes from its western terminus to Mule Creek Junction, Wyoming. US 18 is one of the original United States highways of 1926. The US 18 designation was originally proposed for a road in Michigan from Grand Haven east to Detroit. This roadway was eventually designated as U.S. Route 16.
U.S. Route 212 (US 212) is a spur of US 12. It runs for 949 miles (1,527 km) from Yellowstone National Park to Minnesota Highway 62 at Edina, Minnesota. It does not intersect US 12 now, but it once had an eastern terminus at US 12 in St. Paul, Minnesota. US 212 passes through the states of Minnesota, South Dakota, Wyoming, and Montana. It goes through the cities of Watertown, South Dakota and Billings, Montana.
U.S. Route 136 is an east-west U.S. highway that is a spur route of U.S. Route 36. It runs from Edison, Nebraska, at U.S. Route 6 and U.S. Route 34 to the Interstate 74/Interstate 465 interchange in Speedway, Indiana. This is a distance of 804 miles (1,294 km). US 136 never meets its parent, US 36; however, it does come within two miles of it at its interchange with I-465/I-74 at its eastern terminus.
U.S. Route 169 is a north-south U.S highway that currently runs for 966 miles (1,555 km) from the city of Virginia, Minnesota to Tulsa, Oklahoma at Memorial Drive.
Iowa Highway 13 is a north–south highway in eastern Iowa. It has a length of 85+1⁄4 miles (137.2 km). The southern terminus of Iowa Highway 13 is at U.S. Highway 30 (US 30) south of Bertram and southeast of Cedar Rapids. The northern terminus is at US 52 in rural Clayton County near the towns of Monona and Farmersburg near the intersection of US 52 and US 18.
Iowa Highway 9 is the most northern of Iowa's east–west highways, traversing the entire northern tier of counties. It runs from the eastern terminus of South Dakota Highway 42 at the South Dakota border east of Sioux Falls, South Dakota near Benclare, to the Wisconsin border at Lansing where it continues as Wisconsin Highway 82. It is largely rural in character, bypassing any large city. Making a few dips north and south, the highway largely follows a very straight east–west alignment.
Iowa Highway 5 is a highway in southern Iowa. It is a north–south highway with a length of 105 miles (169 km). It is the northernmost segment of a three-state "Highway 5" also involving Missouri Route 5 and Arkansas Highway 5. Portions of the highway are freeway and expressway. It had previously been designated Iowa Highway 60. The southern terminus of Iowa Highway 5 is at the Missouri border southwest of Cincinnati. Its northern terminus is at Interstate 35 at West Des Moines.
Iowa Highway 3 (Iowa 3) is a state highway that runs from east to west across the state of Iowa. It is the longest state highway in Iowa, at 323 miles (520 km) long. Iowa 3 begins at the South Dakota state line where it continues as South Dakota Highway 50 and ends at the Northwest Arterial at the Dubuque city limits. It is designated the American Veterans Memorial Highway for its entirety. It is located approximately halfway between Interstate 80 and Interstate 90.
Iowa Highway 2 is a 251-mile-long (404 km) state highway which runs across the southernmost tier of counties in the U.S. state of Iowa. At no point along its route is Iowa 2 more than 15 miles (24 km) from the Missouri state line, except for a small section near its eastern terminus. Iowa 2 stretches across the entire state; from the Missouri River near Nebraska City, Nebraska, to U.S. Highway 61 (US 61) at Fort Madison. Prior to becoming a primary highway, the route was known as the Waubonsie Trail.
Iowa Highway 10 is a state highway that runs 104+1⁄2 miles (168.2 km) across the state of Iowa. It begins where South Dakota Highway 46 crosses the Big Sioux River into Iowa north of Hawarden. It ends east of Havelock at an intersection with Iowa Highway 4.
Minnesota State Highway 56 (MN 56) is a 99.121-mile-long (159.520 km) highway in southeast Minnesota, which runs from its intersection with U.S. Highway 63 near the Iowa state line and Chester, Iowa, and continues north to its northern terminus at its junction with U.S. Highway 52 and State Highway 50 in Hampton.
U.S. Highway 20 in Iowa is a major east–west artery which runs across the state, separating the northern third of Iowa from the southern two-thirds. It enters Iowa from Nebraska, concurrent with Interstate 129 and U.S Route 75, crossing the Missouri River at Sioux City. US 20 runs in a more-or-less straight line across Iowa, paralleling 42° 27' N. It leaves Iowa in Dubuque by crossing the Mississippi River into Illinois. Since October 2018, US 20 is a four-lane divided highway for its entire length in Iowa.
Iowa Highway 175 (Iowa 175) is a main east–west route in the northern portion of the state. The highway has a length of 221 miles (356 km). Iowa Highway 175 enters the state by a Missouri River crossing between Decatur, Nebraska and Onawa. The highway continues westward as Nebraska Highway 51. Iowa 175's eastern terminus is at a T intersection with U.S. Highway 63 (US 63) in southwestern Black Hawk County.
Nebraska Highway 36 is a highway in Nebraska. Its western terminus is 0.17 miles (270 m) southwest of U.S. Highway 275 near Fremont, and its eastern terminus is at U.S. Highway 75 in Omaha.
Iowa 3 near Aurelia 
US 71 at Storm Lake 
US 169 at Fort Dodge 
