JAKMIP2

JAKMIP2
Identifiers
Aliases	JAKMIP2 , JAMIP2, NECC1, janus kinase and microtubule interacting protein 2
External IDs	OMIM: 611197 MGI: 1923467 HomoloGene: 8866 GeneCards: JAKMIP2
Gene location (Human)
Chr.	Chromosome 5 (human)
End	147,782,775 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	43,820,838 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; middle temporal gyrus; ; ganglionic eminence; ; corpus callosum; ; entorhinal cortex; ; prefrontal cortex; ; postcentral gyrus; ; Brodmann area 46; ; inferior olivary nucleus; ; superior frontal gyrus;
	Top expressed in
	habenula; ; piriform cortex; ; mammillary body; ; ventromedial nucleus; ; subiculum; ; cerebellar vermis; ; lateral hypothalamus; ; primary motor cortex; ; olfactory tubercle; ; ventral tegmental area;
	More reference expression data
	n/a
Orthologs
	9832
	76217
	ENSG00000176049
	ENSMUSG00000024502
	Q96AA8
	D3YXK0
	NM_014790 ; NM_001270934 ; NM_001270941 ; NM_001282282
	NM_001163637
	NP_001257863 ; NP_001257870 ; NP_001269211 ; NP_055605
	NP_001157109
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 17, 2023

Janus kinase and microtubule interacting protein 2 is a protein that in humans is encoded by the JAKMIP2 gene. ^[5]

Function

The protein encoded by this gene is reported to be a component of the Golgi matrix. It may act as a golgin protein by negatively regulating transit of secretory cargo and by acting as a structural scaffold of the Golgi. Alternative splicing results in multiple transcript variants.

Related Research Articles

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Ninein is a protein that in humans is encoded by the NIN gene.

Golgin subfamily A member 3 is a protein that in humans is encoded by the GOLGA3 gene.

Bicaudal D cargo adaptor 2 is a protein that in humans is encoded by the BICD2 gene.

Golgin subfamily A member 5 is a protein that in humans is encoded by the GOLGA5 gene.

Golgin-45 is a protein that in humans is encoded by the BLZF1 gene.

Protein Hook homolog 1 is a protein that in humans is encoded by the HOOK1 gene.

MAP/microtubule affinity-regulating kinase 4 is an enzyme that in humans is encoded by the MARK4 gene. MARK4 belongs to the family of serine/threonine kinases that phosphorylate microtubule-associated proteins (MAP) causing their detachment from microtubules. Detachment thereby increases microtubule dynamics and facilitates a number of cell activities including cell division, cell cycle control, cell polarity determination, and cell shape alterations.

Centrosomal protein 170kDa, also known as CEP170, is a protein that in humans is encoded by the CEP170 gene.

Protein Hook homolog 3 is a protein that in humans is encoded by the HOOK3 gene.

Golgin subfamily A member 1 is a protein that in humans is encoded by the GOLGA1 gene.

Serine/threonine-protein kinase H1 is an enzyme that in humans is encoded by the PSKH1 gene.

Myomegalin, also known as phosphodiesterase 4D-interacting protein or cardiomyopathy-associated protein 2, is a protein that in humans is encoded by the PDE4DIP gene. It has roles in the formation of microtubules from the centrosome. Its name derives from the fact that it is highly expressed in units of tubular myofibrils known as sarcomeres and is a large protein, at 2,324 amino acids. It was first characterised in 2000.

RAB6-interacting golgin also known as N-terminal kinase-like-binding protein 1 (NTKL-BP1) or SCY1-like 1-binding protein 1 (SCYL1-BP1) is a protein that in humans is encoded by the GORAB gene.

Protein Hook homolog 2 (HK2) is a protein that in humans is encoded by the HOOK2 gene.

<span class="mw-page-title-main">TUBG1</span> Tubulin protein

Tubulin, gamma 1 is a protein in humans that is encoded by the TUBG1 gene. This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle.

Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene. Fasudil is an inhibitor of ROCK protein.

Janus kinase and microtubule interacting protein 3 is a protein that in humans is encoded by the JAKMIP3 gene.

Coiled-coil domain-containing protein 181 (CCDC181) is a protein that in human is encoded by C1orf114, which is located at the Chromosome 1 at 1q24.2. The accession is Q5T1D7. Researches have recently revealed that CCDC 181 is a microtubule-binding protein that interacts with murine Hook1 in haploid male germ cells and localizes to the sperm tail and motile cilia. The disruption of Hook1 may lead to inappropriate function of spermatogenesis. The dysfunction may be related to the abnormal head shape of sperm or distinctive structural changes in flagella in sperm, which can result in male infertility. An increased rate of my gene has found in the haploid phase of male cell during meiosis, thus it is believed to relate to sperm cell and aid in spermatogenesis.

Coiled-coil domain containing 88B is a protein that in humans is encoded by the CCDC88B gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000176049 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024502 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Janus kinase and microtubule interacting protein 2" . Retrieved 2017-05-31.

JAKMIP2

Contents

Function

Related Research Articles

References

Further reading