JGB-1-155

JGB-1-155
Clinical data
Drug class	NAMPT positive allosteric modulator
Identifiers
	IUPAC name N-[[4-(dimethylamino)phenyl]methyl]-N-[2-(2,2-dimethyl-4-propan-2-yloxan-4-yl)ethyl]furan-2-carboxamide;
CAS Number	3011930-28-9 ;
PubChem CID	170327283 ;
ChemSpider	129885828 ;
ChEMBL	ChEMBL5430209 ;
Chemical and physical data
Formula	C26H38N2O3
Molar mass	426.601 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES CC(C)C1(CCOC(C1)(C)C)CCN(CC2=CC=C(C=C2)N(C)C)C(=O)C3=CC=CO3;
	InChI InChI=1S/C26H38N2O3/c1-20(2)26(14-17-31-25(3,4)19-26)13-15-28(24(29)23-8-7-16-30-23)18-21-9-11-22(12-10-21)27(5)6/h7-12,16,20H,13-15,17-19H2,1-6H3; Key:XUAJYFDMEHVNTH-UHFFFAOYSA-N;

Last updated November 23, 2025

JGB-1-155, is a drug which acts as a selective positive allosteric modulator of the enzyme nicotinamide phosphoribosyltransferase (NAMPT). It has neuroprotective effects, and was developed as a potential treatment for neurodegenerative diseases such as Alzheimer's disease.^[1]

References

↑ Gordon-Blake J, Ratia K, Weidig V, Velma GR, Ackerman-Berrier M, Penton C, et al. (February 2024). "Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress". ACS Medicinal Chemistry Letters. 15 (2): 205–214. doi:10.1021/acsmedchemlett.3c00391. PMC 10860701 . PMID 38352833.

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[1] Gordon-Blake J, Ratia K, Weidig V, Velma GR, Ackerman-Berrier M, Penton C, et al. (February 2024). "Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress". ACS Medicinal Chemistry Letters. 15 (2): 205–214. doi:10.1021/acsmedchemlett.3c00391. PMC 10860701 . PMID 38352833.

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