Jill Trewhella

Last updated

Jill Trewhella Jill Trewhella.jpg
Jill Trewhella

Jill Trewhella FAAAS FLANL Dist FRSN [1] is a biophysicist who has worked in both Australia and the United States.

Contents

Early life

Born in Gosford to parents John and Joy, [2] Trewhella planned a career as a high school mathematics teacher in Newcastle, [1] but after the death of her brother enrolled at his alma mater, the University of New South Wales, [3] where she received a Bachelor of Science degree with a double major in applied mathematics and physics and first class honours in physics in 1974. [2] She also received her MSc in physics from UNSW before moving to the University of Sydney to complete her PhD in inorganic chemistry supervised by Peter Wright in 1980. [2]

In 1991 she married Don Parkin. [2]

Career

After completing her doctorate, she spent four years at Yale University as a postdoctoral associate in the Department of Molecular Biophysics and Biochemistry. [2] From Yale, Trewhella moved to Los Alamos National Laboratory in 1984 and held various roles there over a twenty-year period. [2] In 1999 she was named a laboratory fellow. She was the first woman to earn the honor. By 2003 she was Bioscience Division Leader and Program Manager for the Department of Energy Office of Biological and Environmental Research. She was consulted by press and the United States government about bioterrorism during the 2001 anthrax attacks. [2] She held an adjunct associate professorship at the University of New Mexico. [4]

In 2004-2005 Trewhella spent a year at the University of Utah as Director of Special Projects, developing major new initiatives involving collaborative research projects and bidding successfully for a National Institutes of Health Research Centre of Excellence. She returned to Sydney in 2005 as an Australian Research Council Federation Fellow to join the School of Molecular Bioscience in the Faculty of Science at the University of Sydney. [1]

In 2009 Trewhella took up the position of Deputy Vice-Chancellor (Research), [1] [5] within the University of Sydney's senior executive group. Her role was to work in partnership with academic leaders across the university to maintain and develop Sydney's research position within Australia and internationally, overseeing the development of major collaborative, cross-disciplinary research programs and providing supporting infrastructure. During her tenure the Charles Perkins Centre was established. [6]

In 2015, Trewhella took up the Tage Erlander Visiting Professorship in Sweden, based mainly at Linköping University, [7] where she networked with Swedish researchers to develop projects that would take advantage of new infrastructure for X-ray and neutron scattering studies to characterize materials, including biological materials where the object was to understand biological function and provide a foundation for advances in medicine and biotechnology. Having completed her Tage Erlander Visiting Professorship, she now continues her interests in science as a Professor Emerita at Sydney in the Faculty of Science and an adjunct professor of chemistry at the University of Utah.

Research

Trewhella's research focuses on the use of chemistry, physics and computational methods to study bio-molecular structures as a basis for understanding their functions. [6] She uses small angle x-ray scattering to investigate protein structure. [5]

Trewhella has published more than 150 research papers, book chapters, essays, articles and reports. [6] Her work has been recognised with a number of competitive research grants, awards and honours, [6] including being named as a fellow of the Neutron Scattering Society of America in 2010, [8] and a distinguished fellow of the Royal Society of New South Wales in 2011. [1] She holds a joint appointment at the Bragg Institute within the Australian Nuclear Science and Technology Organisation (ANSTO) and is an adjunct professor of chemistry at the University of Utah. [6]

Selected publications

Related Research Articles

<span class="mw-page-title-main">Biophysics</span> Study of biological systems using methods from the physical sciences

Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations. Biophysical research shares significant overlap with biochemistry, molecular biology, physical chemistry, physiology, nanotechnology, bioengineering, computational biology, biomechanics, developmental biology and systems biology.

<span class="mw-page-title-main">Gregory Petsko</span> American biochemist and academic

Gregory A. Petsko is an American biochemist and member of the National Academy of Sciences, the National Academy of Medicine, the American Academy of Arts and Sciences, and the American Philosophical Society. He is currently Professor of Neurology at the Ann Romney Center for Neurologic Diseases at Harvard Medical School and Brigham and Women's Hospital. He formerly had an endowed professorship in Neurology and Neuroscience at Weill Cornell Medical College and is still an adjunct professor of Biomedical Engineering at Cornell University, and is also the Gyula and Katica Tauber Professor, Emeritus, in biochemistry and chemistry at Brandeis University. On October 24, 2023, in a ceremony in the East Room of the White House, President Joe Biden presented Gregory Petsko and eight others with the National Medal of Science, the highest honor the United States can bestow on a scientist and engineer.

<span class="mw-page-title-main">Athene Donald</span> British physicist

Dame Athene Margaret Donald is a British physicist. She is Professor Emerita of Experimental Physics at the University of Cambridge, and Master of Churchill College, Cambridge.

<span class="mw-page-title-main">Macromolecular assembly</span>

The term macromolecular assembly (MA) refers to massive chemical structures such as viruses and non-biologic nanoparticles, cellular organelles and membranes and ribosomes, etc. that are complex mixtures of polypeptide, polynucleotide, polysaccharide or other polymeric macromolecules. They are generally of more than one of these types, and the mixtures are defined spatially, and with regard to their underlying chemical composition and structure. Macromolecules are found in living and nonliving things, and are composed of many hundreds or thousands of atoms held together by covalent bonds; they are often characterized by repeating units. Assemblies of these can likewise be biologic or non-biologic, though the MA term is more commonly applied in biology, and the term supramolecular assembly is more often applied in non-biologic contexts. MAs of macromolecules are held in their defined forms by non-covalent intermolecular interactions, and can be in either non-repeating structures, or in repeating linear, circular, spiral, or other patterns. The process by which MAs are formed has been termed molecular self-assembly, a term especially applied in non-biologic contexts. A wide variety of physical/biophysical, chemical/biochemical, and computational methods exist for the study of MA; given the scale of MAs, efforts to elaborate their composition and structure and discern mechanisms underlying their functions are at the forefront of modern structure science.

Stephen H. White is an American Biophysicist, academic, and author. He is a Professor Emeritus of Physiology and Biophysics at the University of California, Irvine.

<span class="mw-page-title-main">Judith Klinman</span> American biochemist

Judith P. Klinman is an American chemist, biochemist, and molecular biologist known for her work on enzyme catalysis. She became the first female professor in the physical sciences at the University of California, Berkeley in 1978, where she is now Professor of the Graduate School and Chancellor's Professor. In 2012, she was awarded the National Medal of Science by President Barack Obama. She is a member of the National Academy of Sciences, American Academy of Arts and Sciences, American Association for the Advancement of Science, and the American Philosophical Society.

<span class="mw-page-title-main">G. Marius Clore</span> Molecular biophysicist, structural biologist

G. Marius Clore MAE, FRSC, FMedSci, FRS is a British-born, Anglo-American molecular biophysicist and structural biologist. He was born in London, U.K. and is a dual U.S./U.K. Citizen. He is a Member of the National Academy of Sciences, a Fellow of the Royal Society, a Fellow of the Academy of Medical Sciences, a Fellow of the American Academy of Arts and Sciences, a NIH Distinguished Investigator, and the Chief of the Molecular and Structural Biophysics Section in the Laboratory of Chemical Physics of the National Institute of Diabetes and Digestive and Kidney Diseases at the U.S. National Institutes of Health. He is known for his foundational work in three-dimensional protein and nucleic acid structure determination by biomolecular NMR spectroscopy, for advancing experimental approaches to the study of large macromolecules and their complexes by NMR, and for developing NMR-based methods to study rare conformational states in protein-nucleic acid and protein-protein recognition. Clore's discovery of previously undetectable, functionally significant, rare transient states of macromolecules has yielded fundamental new insights into the mechanisms of important biological processes, and in particular the significance of weak interactions and the mechanisms whereby the opposing constraints of speed and specificity are optimized. Further, Clore's work opens up a new era of pharmacology and drug design as it is now possible to target structures and conformations that have been heretofore unseen.

Alice Vrielink is a structural biologist and Professor of Structural Biology in the School of Molecular Sciences at the University of Western Australia. She is known for her work determining the structures of macromolecules such as enzymes and nucleic acids.

<span class="mw-page-title-main">Sarah L. Keller</span> American biophysicist

Sarah L. Keller is an American biophysicist, studying problems at the intersection between biology and chemistry. She investigates self-assembling soft matter systems. Her current main research focus is understanding how simple lipid mixtures within bilayer membranes give rise to membrane's complex phase behavior.

<span class="mw-page-title-main">Mei Hong (chemist)</span> Chinese-American chemist

Mei Hong is a Chinese-American biophysical chemist and professor of chemistry at the Massachusetts Institute of Technology. She is known for her creative development and application of solid-state nuclear magnetic resonance (ssNMR) spectroscopy to elucidate the structures and mechanisms of membrane proteins, plant cell walls, and amyloid proteins. She has received a number of recognitions for her work, including the American Chemical Society Nakanishi Prize in 2021, Günther Laukien Prize in 2014, the Protein Society Young Investigator award in 2012, and the American Chemical Society’s Pure Chemistry award in 2003.

Hui Wu is a Chinese materials chemist and engineer. She is a senior scientist at the National Institute of Standards and Technology Center for Neutron Research. Wu researches the synthesis, structure, solid state chemistry, and properties of complex oxides and hydrides. She received the Department of Commerce Bronze Medal for producing an entirely new route to synthesizing hydrogen-storage materials for fuel cells based on the complex chemistry of amines and boranes.

Deborah Beth Zamble was a Canadian chemist and Canada Research Chair in Biological Chemistry at the University of Toronto. Her research considered how bacteria processed metal nutrients.

Emma Raven is a British chemist and chemical biologist. She is a Professor of Chemistry and Head of the School of Chemistry at the University of Bristol. She was previously a Professor at the University of Leicester. Her research work is concerned with the role of heme in biology, in particular on the mechanism of action, structures and biological function of heme proteins.

Rachel Wong is an American neuroscientist who is a professor of Biological Structure at the University of Washington. She studies the developmental mechanisms that determine synaptic connectivity in the central nervous system. She was elected to the National Vision Research Institute of Australia in 2018 and the National Academy of Sciences in 2021.

Jean Baum is an American chemist. She is the distinguished professor of chemistry and chemical biology at Rutgers University, where she is also vice dean for research and graduate education in the school of arts and sciences, and also vice chair of the department of chemistry and chemical biology. Her research investigates protein–protein interaction and protein aggregation using nuclear magnetic resonance spectroscopy (NMR) and other biochemical and biophysical techniques. She serves as treasurer for the Protein Society.

<span class="mw-page-title-main">Nikolay Dokholyan</span> Russian-American Biophysicist, academic and researcher

Nikolay V. Dokholyan is an American biophysicist, academic and researcher. He is a G. Thomas Passananti Professor and Vice Chair for Research at Penn State College of Medicine.

Suzanne Frances Scarlata is the Richard Whitcomb Professor at Worcester Polytechnic Institute. She is known for her work on how cells respond to hormones and neurotransmitters. She is an elected fellow of the American Association for the Advancement of Science.

Linda Columbus is an American chemist who is Professor of Chemistry and Molecular Physiology at the University of Virginia. Her research considers the structure-function properties of membrane proteins.

Vanessa K. Peterson is a Neutron Instrument Scientist, at the Australian Nuclear Science and Technology Organisation (ANSTO). She established an independent research program at ANSTO which specialised on improving understanding of energy systems and how they work. She manages the Echidna program, a high-resolution powder diffractometer, as well as Wombat - a high-intensity powder diffractometer. Peterson's expertise includes synchtron and laboratory x-ray techniques, as well as neutron powder diffraction, as well as single crystal x-ray diffraction.

<span class="mw-page-title-main">Thomas Vogt</span> German material scientist (born 1958)

Thomas Vogt is a German chemist and material scientist. He is an Educational Foundation Distinguished Professor in the Department of Chemistry and Biochemistry at the University of South Carolina.

References

  1. 1 2 3 4 5 "Distinguished Fellows of the Royal Society of New South Wales". Royal Society of New South Wales. Archived from the original on 29 November 2014. Retrieved 10 December 2014.
  2. 1 2 3 4 5 6 7 "Biophysicist in Profile" (PDF). Biophysical Society. July 2003. Retrieved 10 December 2014.
  3. McCarthy, Joanne (20 November 2004). "Frontline scientist; PROFILE". Newcastle Herald. p. 18.
  4. Parks, Clinton (2 July 2004). "Leaving Los Alamos". Science Careers. Science. Retrieved 10 December 2014.
  5. 1 2 Lane, Bernard (18 February 2009). "Scientist delves across the disciplines". The Australian. p. 21.
  6. 1 2 3 4 5 "Professor Jill Trewhella". Research and Innovation. The University of Sydney. Retrieved 10 December 2014.
  7. "Decisions on Visiting Fellowships". Research Funding. Vetenskapsrådet. 29 October 2014. Retrieved 10 December 2014.
  8. "NSSA Fellows". Neutron Scattering Society of America. Retrieved 10 December 2014.