 | This biographical article is written like a résumé .(May 2010) |
Jonathan Borden | |
|---|---|
| Born | October 31, 1962 |
| Occupation | Neurosurgeon |
| Website | http://jonathanborden-md.com/ |
Jonathan Alan Borden (born October 31, 1962) is an American neurosurgeon who developed the Borden Classification of Dural Arteriovenous Fistulas. He has been involved in internet based telemedicine applications [1] and is an editor of the RDDL specification for XML Namespaces.
Borden was born on October 31, 1962, in Rochester, New York, However, he was raised in Hartford, Connecticut.[ citation needed ] Borden graduated from Amherst College in Amherst, Massachusetts, with a Bachelor of Arts in Neuroscience and Yale University School of Medicine. He completed his internship and residency in Neurosurgery at Tufts University in Boston, Massachusetts.[ citation needed ]
His scientific work has involved the application of computer science to neurobiology. [2] Borden's earliest work used artificial intelligence techniques to model neurochemical networks in the brain. He used computer graphics techniques to analyze the results of molecular biological experiments. Working in the laboratory of Elias Manuelidis and Laura Manuelidis at Yale School of Medicine, he authored papers on the organization of interphase chromosomes in human brain tissue. [3] [4] [5]
At Tufts-New England Medical Center he developed the Borden Classification of Dural Arteriovenous Fistulas. [6] This classification has come into common usage after its clinical applicability has been verified by the University of Toronto Brain AVM Group [7]
Dr. Borden was an Assistant Professor of Neurosurgery at Tufts University in Boston from 1995 to 2002. He was the director of the Boston Gamma Knife Center. He and Tim Bray are co-editors of the RDDL specification. [8] [ self-published source? ] He authored the XMTP specification, [9] [ self-published source? ] an early method to represent SMTP/RFC 811 email in XML. He is an advisor for the Science Directorate of NASA, has been an invited expert for the World Wide Web Consortium Web Ontology Working Group and has been actively involved in the development and standardization of XML based electronic medical records. [10]
More recently Dr. Borden has been involved in research studies aimed at repairing degenerated intervertebral discs using growth factors, [11] [ self-published source? ] stem cells and minimally invasive surgical techniques. [12]
An arteriovenous malformation (AVM) is an abnormal connection between arteries and veins, bypassing the capillary system. Usually congenital, this vascular anomaly is widely known because of its occurrence in the central nervous system, but can appear anywhere in the body. The symptoms of AVMs can range from none at all to intense pain or bleeding, and they can lead to other serious medical problems.
A cerebral arteriovenous malformation is an abnormal connection between the arteries and veins in the brain—specifically, an arteriovenous malformation in the cerebrum.
Foix–Alajouanine syndrome, also called subacute ascending necrotizing myelitis, is a disease caused by an arteriovenous malformation of the spinal cord. In particular, most cases involve dural arteriovenous malformations that present in the lower thoracic or lumbar spinal cord. The condition is named after Charles Foix and Théophile Alajouanine who first described the condition in 1926.
Meningioma, also known as meningeal tumor, is typically a slow-growing tumor that forms from the meninges, the membranous layers surrounding the brain and spinal cord. Symptoms depend on the location and occur as a result of the tumor pressing on nearby tissue. Many cases never produce symptoms. Occasionally seizures, dementia, trouble talking, vision problems, one sided weakness, or loss of bladder control may occur.
Stereotactic surgery is a minimally invasive form of surgical intervention that makes use of a three-dimensional coordinate system to locate small targets inside the body and to perform on them some action such as ablation, biopsy, lesion, injection, stimulation, implantation, radiosurgery (SRS), etc.
Moyamoya disease is a disease in which certain arteries in the brain are constricted. Blood flow is blocked by constriction and blood clots (thrombosis). A collateral circulation develops around the blocked vessels to compensate for the blockage, but the collateral vessels are small, weak, and prone to bleeding, aneurysm and thrombosis. On conventional angiography, these collateral vessels have the appearance of a "puff of smoke".
Fluorescence in situ hybridization (FISH) is a molecular cytogenetic technique that uses fluorescent probes that bind to only particular parts of a nucleic acid sequence with a high degree of sequence complementarity. It was developed by biomedical researchers in the early 1980s to detect and localize the presence or absence of specific DNA sequences on chromosomes. Fluorescence microscopy can be used to find out where the fluorescent probe is bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific RNA targets in cells, circulating tumor cells, and tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues.
A carotid-cavernous fistula results from an abnormal communication between the arterial and venous systems within the cavernous sinus in the skull. It is a type of arteriovenous fistula. As arterial blood under high pressure enters the cavernous sinus, the normal venous return to the cavernous sinus is impeded and this causes engorgement of the draining veins, manifesting most dramatically as a sudden engorgement and redness of the eye of the same side.
The superior petrosal sinus is one of the dural venous sinuses located beneath the brain. It receives blood from the cavernous sinus and passes backward and laterally to drain into the transverse sinus. The sinus receives superior petrosal veins, some cerebellar veins, some inferior cerebral veins, and veins from the tympanic cavity. They may be affected by arteriovenous malformation or arteriovenous fistula, usually treated with surgery.
A dural arteriovenous fistula (DAVF) or malformation is an abnormal direct connection (fistula) between a meningeal artery and a meningeal vein or dural venous sinus.
Molecular cytogenetics combines two disciplines, molecular biology and cytogenetics, and involves the analysis of chromosome structure to help distinguish normal and cancer-causing cells. Human cytogenetics began in 1956 when it was discovered that normal human cells contain 46 chromosomes. However, the first microscopic observations of chromosomes were reported by Arnold, Flemming, and Hansemann in the late 1800s. Their work was ignored for decades until the actual chromosome number in humans was discovered as 46. In 1879, Arnold examined sarcoma and carcinoma cells having very large nuclei. Today, the study of molecular cytogenetics can be useful in diagnosing and treating various malignancies such as hematological malignancies, brain tumors, and other precursors of cancer. The field is overall focused on studying the evolution of chromosomes, more specifically the number, structure, function, and origin of chromosome abnormalities. It includes a series of techniques referred to as fluorescence in situ hybridization, or FISH, in which DNA probes are labeled with different colored fluorescent tags to visualize one or more specific regions of the genome. Introduced in the 1980s, FISH uses probes with complementary base sequences to locate the presence or absence of the specific DNA regions. FISH can either be performed as a direct approach to metaphase chromosomes or interphase nuclei. Alternatively, an indirect approach can be taken in which the entire genome can be assessed for copy number changes using virtual karyotyping. Virtual karyotypes are generated from arrays made of thousands to millions of probes, and computational tools are used to recreate the genome in silico.
Laura Manuelidis is a physician and neuropathologist at Yale University.
Ayub Khan Ommaya, MD, ScD (hc), FRCS, FACS was a Pakistani American neurosurgeon and the inventor of the Ommaya reservoir. The reservoir is used to provide chemotherapy directly to the tumor site for brain tumors. Ommaya was also a leading expert in traumatic brain injuries.
A cerebrospinal fluid leak is a medical condition where the cerebrospinal fluid (CSF) surrounding the brain or spinal cord leaks out of one or more holes or tears in the dura mater. A cerebrospinal fluid leak can be either cranial or spinal, and these are two different disorders. A spinal CSF leak can be caused by one or more meningeal diverticula or CSF-venous fistulas not associated with an epidural leak.
Thomas Cremer, is a German professor of human genetics and anthropology with a main research focus on molecular cytogenetics and 3D/4D analyses of nuclear structure studied by fluorescence microscopy including super-resolution microscopy and live cell imaging. Thomas Cremer is the brother of the German physicist Christoph Cremer and Georg Cremer, Secretary General of the German Caritas Association.
Axel Herbert Olivecrona was a Swedish professor and brain surgeon, credited with founding the field of Swedish neurosurgery, and pioneering developments in modern neurosurgery.
Cavernous hemangioma, also called cavernous angioma, venous malformation, or cavernoma, is a type of venous malformation due to endothelial dysmorphogenesis from a lesion which is present at birth. A cavernoma in the brain is called a cerebral cavernous malformation or CCM. Despite its designation as a hemangioma, a cavernous hemangioma is not a tumor as it does not display endothelial hyperplasia. The abnormal tissue causes a slowing of blood flow through the cavities, or "caverns". The blood vessels do not form the necessary junctions with surrounding cells, and the structural support from the smooth muscle is hindered, causing leakage into the surrounding tissue. It is the leakage of blood, referred to as hemorrhage, that causes a variety of symptoms known to be associated with the condition.
Aaron A. Cohen-Gadol is a professor of neurological surgery in the department of neurosurgery at Indiana University School of Medicine and a neurosurgeon at Indiana University Health specializing in the surgical treatment of complex brain tumors, vascular malformations, cavernous malformations, etc. He performs removal of brain tumors via minimally invasive endoscopic techniques, which use the nasal pathways instead of opening the skull.
Interventional neuroradiology (INR) also known as neurointerventional surgery (NIS), endovascular therapy (EVT), endovascular neurosurgery, and interventional neurology is a medical subspecialty of neurosurgery, neuroradiology, intervention radiology and neurology specializing in minimally invasive image-based technologies and procedures used in diagnosis and treatment of diseases of the head, neck, and spine.
Primo Dorello (1872–1963) was an Italian anatomist. He is best known for identifying Dorello's canal.