Journal of Thoracic Oncology

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Limited-stage small cell lung carcinoma (LS-SCLC) is a type of small cell lung cancer (SCLC) that is confined to an area which is small enough to be encompassed within a radiation portal. This generally includes cancer to one side of the lung and those might have reached the lymph nodes on the same side of the lung. 33% patients with small cell lung cancer are diagnosed with limited-stage small cell lung carcinoma when it is first found. Common symptoms include but are not limited to persistent cough, chest pain, rust-coloured sputum, shortness of breath, fatigue, weight loss, wheezing, hoarseness and recurrent respiratory tract infections such as pneumonia and bronchitis. Nervous system problems, Cushing syndrome and SIADH can also be associated with small cell lung cancer. Unlike extensive-stage small cell lung cancer, limited-stage small cell lung carcinoma is potentially curable. Standard treatments consist of surgery, platinum-based combination chemotherapy, thoracic irradiation, and prophylactic cranial irradiation. Patient five-year survival rate has significantly increased from 1% with surgery to 26% after the application of combination chemotherapy.

Valerie W Rusch, MD, FACS, is an American thoracic surgeon who is currently the Miner Family Chair for Intrathoracic Cancers and Vice Chair for Clinical Research, Department of Surgery, at Memorial Sloan Kettering Cancer Center.

Julie Renee Brahmer is an American thoracic oncologist. She is the Co-Director of the Upper Aerodigestive Department within the Bloomberg~Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University and the Marilyn Meyerhoff Professor in Thoracic Oncology.

References

  1. "Journal of Thoracic Oncology". 2018 Journal Citation Reports. Web of Science (Science ed.). Clarivate Analytics. 2019.