Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a blood clot. It potentially results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The mechanism of coagulation involves activation, adhesion and aggregation of platelets, as well as deposition and maturation of fibrin.
Antiphospholipid syndrome, or antiphospholipid antibody syndrome, is an autoimmune, hypercoagulable state caused by antiphospholipid antibodies. APS can lead to blood clots (thrombosis) in both arteries and veins, pregnancy-related complications, and other symptoms like low platelets, kidney disease, heart disease, and rash. Although the exact etiology of APS is still not clear, genetics is believed to play a key role in the development of the disease. Diagnosis is made based on symptoms and testing, but sometimes research criteria are used to aid in diagnosis. The research criteria for definite APS requires one clinical event and two positive blood test results spaced at least three months apart that detect lupus anticoagulant, anti-apolipoprotein antibodies, and/or anti-cardiolipin antibodies.
Fibrinogen is a glycoprotein complex, produced in the liver, that circulates in the blood of all vertebrates. During tissue and vascular injury, it is converted enzymatically by thrombin to fibrin and then to a fibrin-based blood clot. Fibrin clots function primarily to occlude blood vessels to stop bleeding. Fibrin also binds and reduces the activity of thrombin. This activity, sometimes referred to as antithrombin I, limits clotting. Fibrin also mediates blood platelet and endothelial cell spreading, tissue fibroblast proliferation, capillary tube formation, and angiogenesis and thereby promotes revascularization and wound healing.
Plasminogen activator inhibitor-1 (PAI-1) also known as endothelial plasminogen activator inhibitor is a protein that in humans is encoded by the SERPINE1 gene. Elevated PAI-1 is a risk factor for thrombosis and atherosclerosis.
Nature Reviews Cardiology is a monthly peer-reviewed scientific journal published by Nature Portfolio. It was established in 2004 as Nature Clinical Practice Cardiovascular Medicine, but change name in April 2009. The editor-in-chief is Gregory Lim.
Paget–Schroetter disease is a form of upper extremity deep vein thrombosis (DVT), a medical condition in which blood clots form in the deep veins of the arms. These DVTs typically occur in the axillary and/or subclavian veins.
Vascular disease is a class of diseases of the vessels of the circulatory system in the body, including blood vessels – the arteries and veins, and the lymphatic vessels. Vascular disease is a subgroup of cardiovascular disease. Disorders in this vast network of blood and lymph vessels can cause a range of health problems that can sometimes become severe, and fatal. Coronary heart disease for example, is the leading cause of death for men and women in the United States.
Post-thrombotic syndrome (PTS), also called postphlebitic syndrome and venous stress disorder is a medical condition that may occur as a long-term complication of deep vein thrombosis (DVT).
Edward (Ted) G. D. Tuddenham FMedSci is considered one of the world's leading haematologists having authored over 200 papers in the field. He gained his Bachelor of Medicine, Bachelor of Surgery at the University of London in 1968 and his Membership of the Royal College of Physicians in 1975. Up until 2005 was head of the Haemostasis and Thrombosis Research Group at Imperial College. Professor Tuddenham is a pioneer in the field of haemophilia and was responsible, along with Frances Rotblat, for the purification and cloning of the factor VIII gene, which led to the highly effective and safe treatments available to haemophilia sufferers today. In more recent years, he has been actively involved in developing gene therapy for haemophilia. The first successful use of gene transfer to convert severe to mild haemophilia B was reported by his group in December 2011.He retired from Directorship of the Katharine Dormandy Centre in July 2011 and is now Emeritus Professor of Haemophilia at University College London. He continues to work in the Haemophilia Centre at the Royal Free Hospital on gene therapy clinical trials, with the goal of curing all forms of haemophilia.
Atherosclerosis is a monthly peer-reviewed scientific journal established in 1970 and published by Elsevier. It is the official journal of the European Atherosclerosis Society and is affiliated with the International Atherosclerosis Society.
Nature Physics is a monthly peer-reviewed scientific journal published by Nature Portfolio. It was first published in October 2005. The chief editor is David Abergel.
Clinical and Applied Thrombosis/Hemostasis is a peer-reviewed medical journal covering research in the field of hematology. The editor-in-chief is Charles A. Carter. It was established in 1995 and is published by SAGE Publications.
The International Society on Thrombosis and Haemostasis (ISTH) is a not-for-profit global membership organization of specialists in the field of blood coagulation and its disorders, such as thrombosis and hemophilia. It was founded in 1954 as the International Committee on Thrombosis and Haemostasis (ICTH). The society was reorganized in 1969 as the ISTH. It currently represents about 5,000 members from 98 different countries. The society initiates and promotes education and outreach initiatives, research activities, scientific meetings, peer-reviewed publications, expert committees and the development of standards allowing a common language and approach to basic and clinical science all over the world. It also publishes the medical journal Journal of Thrombosis and Haemostasis and its open access counterpart, Research and Practice in Thrombosis and Haemostasis.
Stanley Heptinstall is an Emeritus Professor of the University of Nottingham, Director of Platelet Solutions Ltd, and local government councillor on Nottinghamshire County Council.
Beverley Jane Hunt is professor of thrombosis and haemostasis at King's College, London, consultant in the departments of haematology, rheumatology and pathology and director of the Haemostasis Research Unit at Guy's and St Thomas' Foundation Trust, medical director of Thrombosis UK and previous president of Walthamstow Hall Old Girls Association. She was educated at Walthamstow Hall and University of Liverpool.
The haemostatic system involves the interaction of proteins in the blood, the blood vessel wall and the flow of blood to control bleeding and blood clotting. Developmental Haemostasis is a term that represents the maturation of the haemostatic system from birth to adulthood. There are differences in the concentration, structure and activity of many proteins involved in blood clotting. These changes play an important role in physiological development and are important in providing appropriate diagnosis and treatment of bleeding and clotting disorders. The age-specific differences in the blood clotting system may contribute to the fact that children are less prone to developing thrombosis compared to adults.
Thrombosis and Haemostasis is a peer-review scientific journal of medicine. It is published by Thieme Medical Publishers. It is the official journal of several groups and societies: European Society of Cardiology, Sociedad Española de Trombosis y Hemostasia, Australian Vascular Biology Society, and Gesellschaft für Thrombose- und Hämostaseforschung e.V. A related publication is TH Open. The journal was established in 1957 and is published monthly. The current editors-in-chief are Christian Weber and Gregory Y. H. Lip.
Seminars in Thrombosis and Hemostasis is a peer-reviewed medical review journal covering hematology, with a specific focus on disorders related to thrombosis and hemostasis. It was established in 1974 and is published eight times per year by Thieme Medical Publishers. The editor-in-chief is Emmanuel J. Favaloro. According to the Journal Citation Reports, the journal has a 2018 impact factor of 3.401.
Mary Cushman is an American vascular hematologist. She is a Full professor of Medicine and Pathology in the Robert Larner College of Medicine at the University of Vermont.
Marie Claire McLintock was a New Zealand haematologist and obstetric physician. She was an expert in medical conditions and disorders related to bleeding and blood clotting, and medical problems associated with pregnancy.
