KATNA1

KATNA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RPA
Identifiers
Aliases	KATNA1 , katanin catalytic subunit A1
External IDs	OMIM: 606696; MGI: 1344353; HomoloGene: 56014; GeneCards: KATNA1; OMA:KATNA1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q25.1 Start 149,594,873 bp [1] End 149,648,972 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 A1 Start 7,601,764 bp [2] End 7,638,914 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm secondary oocyte gonad left testis right testis Achilles tendon retinal pigment epithelium testicle gastrocnemius muscle Descending thoracic aorta Top expressed in granulocyte epiblast bone marrow zygote zone of skin ileum primary oocyte thymus secondary oocyte esophagus More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding microtubule binding microtubule-severing ATPase activity protein binding protein heterodimerization activity hydrolase activity ATP binding ATPase activity isomerase activity Cellular component cytoplasm spindle pole midbody microtubule cytoskeleton nucleus microtubule organizing center spindle mitotic spindle pole centrosome Biological process cell division microtubule severing cell cycle cytoplasmic microtubule organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11104 23924 Ensembl ENSG00000186625 ENSMUSG00000019794 UniProt O75449 Q9WV86 RefSeq (mRNA) NM_001204076 NM_007044 NM_011835 RefSeq (protein) NP_001191005 NP_008975 n/a Location (UCSC) Chr 6: 149.59 – 149.65 Mb Chr 10: 7.6 – 7.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Katanin p60 ATPase-containing subunit A1 is an enzyme that in humans is encoded by the KATNA1 gene. ^{[5] [6]}

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000186625 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019794 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. McNally FJ, Thomas S (Jan 1999). "Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs". Mol Biol Cell. 9 (7): 1847–61. doi:10.1091/mbc.9.7.1847. PMC   25426 . PMID   9658175.
6. "Entrez Gene: KATNA1 katanin p60 (ATPase-containing) subunit A 1".

Further reading

• McNally FJ, Vale RD (1993). "Identification of katanin, an ATPase that severs and disassembles stable microtubules". Cell. 75 (3): 419–29. doi:10.1016/0092-8674(93)90377-3. PMID   8221885. S2CID   10264319.
• McNally FJ, Okawa K, Iwamatsu A, Vale RD (1997). "Katanin, the microtubule-severing ATPase, is concentrated at centrosomes". J. Cell Sci. 109 (3): 561–7. doi:10.1242/jcs.109.3.561. PMID   8907702.
• Hartman JJ, Mahr J, McNally K, et al. (1998). "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit". Cell. 93 (2): 277–87. doi: 10.1016/S0092-8674(00)81578-0 . PMID   9568719. S2CID   13583382.
• Ahmad FJ, Yu W, McNally FJ, Baas PW (1999). "An essential role for katanin in severing microtubules in the neuron". J. Cell Biol. 145 (2): 305–15. doi:10.1083/jcb.145.2.305. PMC   2133110 . PMID   10209026.
• Syu LJ, Saltiel AR (1999). "Lipotransin: a novel docking protein for hormone-sensitive lipase". Mol. Cell. 4 (1): 109–15. doi: 10.1016/S1097-2765(00)80192-6 . PMID   10445032.
• McNally KP, Bazirgan OA, McNally FJ (2000). "Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin". J. Cell Sci. 113 (9): 1623–33. doi:10.1242/jcs.113.9.1623. PMID   10751153.
• Buster D, McNally K, McNally FJ (2002). "Katanin inhibition prevents the redistribution of gamma-tubulin at mitosis". J. Cell Sci. 115 (Pt 5): 1083–92. doi:10.1242/jcs.115.5.1083. PMID   11870226.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.