KCTD12

KCTD12
Identifiers
Aliases	KCTD12 , C13orf2, PFET1, PFETIN, potassium channel tetramerization domain containing 12
External IDs	OMIM: 610521; MGI: 2145823; HomoloGene: 16316; GeneCards: KCTD12; OMA:KCTD12 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q22.3 Start 76,880,175 bp [1] End 76,886,405 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 E2.3 Start 103,214,017 bp [2] End 103,220,073 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trigeminal ganglion urethra bronchial epithelial cell lactiferous duct synovial joint mucosa of paranasal sinus superficial temporal artery lower lobe of lung pericardium parietal pleura Top expressed in molar vestibular sensory epithelium granulocyte pineal gland dermis body of femur human fetus lobe of cerebellum skin of external ear cerebellar vermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA binding identical protein binding Cellular component cell junction postsynaptic membrane plasma membrane synapse extracellular exosome presynaptic membrane membrane Biological process protein homooligomerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 115207 239217 Ensembl ENSG00000178695 ENSMUSG00000098557 UniProt Q96CX2 Q6WVG3 RefSeq (mRNA) NM_138444 NM_177715 RefSeq (protein) NP_612453 NP_808383 Location (UCSC) Chr 13: 76.88 – 76.89 Mb Chr 14: 103.21 – 103.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

BTB/POZ domain-containing protein KCTD12 is a protein that in humans is encoded by the KCTD12 gene. ^{[5] [6]}

It may be associated with rumination ^[7] and Bipolar Disorder. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000178695 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000098557 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Resendes BL, Kuo SF, Robertson NG, Giersch AB, Honrubia D, Ohara O, Adams JC, Morton CC (Sep 2004). "Isolation from cochlea of a novel human intronless gene with predominant fetal expression". J Assoc Res Otolaryngol. 5 (2): 185–202. doi:10.1007/s10162-003-4042-x. PMC   2538407 . PMID   15357420.
6. "Entrez Gene: KCTD12 potassium channel tetramerisation domain containing 12".
7. Eszlari, Nora; Millinghoffer, Andras; Petschner, Peter; Gonda, Xenia; Baksa, Daniel; Pulay, Attila J.; Réthelyi, János M.; Breen, Gerome; Deakin, John Francis William; Antal, Peter; Bagdy, Gyorgy; Juhasz, Gabriella (2019). "Genome-wide association analysis reveals KCTD12 and miR-383-binding genes in the background of rumination". Translational Psychiatry. 9 (1): 119. doi:10.1038/s41398-019-0454-1. PMC   6423133 . PMID   30886212.
8. "KCTD12 Gene - GeneCards | KCD12 Protein | KCD12 Antibody".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID   15345747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.