KDM3A

KDM3A
Identifiers
Aliases	KDM3A , JHDM2A, JHMD2A, JMJD1, JMJD1A, TSGA, lysine demethylase 3A
External IDs	OMIM: 611512 MGI: 98847 HomoloGene: 10196 GeneCards: KDM3A
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p11.2 Start 86,440,647 bp [1] End 86,492,716 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 C1 Start 71,565,956 bp [2] End 71,609,974 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Achilles tendon sperm sural nerve skin of abdomen right lung ganglionic eminence gastric mucosa minor salivary gland human penis Top expressed in spermatocyte spermatid seminiferous tubule left lung lobe ganglionic eminence medial ganglionic eminence thymus mirror cumulus cell abdominal wall More reference expression data BioGPS n/a
Gene ontology Molecular function iron ion binding DNA-binding transcription factor activity dioxygenase activity metal ion binding androgen receptor binding oxidoreductase activity histone demethylase activity transcription cis-regulatory region binding chromatin DNA binding histone H3-methyl-lysine-9 demethylase activity protein binding RNA polymerase II core promoter sequence-specific DNA binding Cellular component cytoplasm membrane nucleoplasm nucleus chromatin Biological process androgen receptor signaling pathway cell differentiation regulation of transcription, DNA-templated histone H3-K9 dimethylation regulation of stem cell differentiation regulation of stem cell population maintenance transcription, DNA-templated positive regulation of transcription, DNA-templated spermatogenesis hormone-mediated signaling pathway negative regulation of histone H3-K9 methylation regulation of gene expression formaldehyde biosynthetic process spermatid nucleus elongation positive regulation of transcription by RNA polymerase II histone H3-K9 demethylation cellular response to leukemia inhibitory factor chromatin organization positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55818 104263 Ensembl ENSG00000115548 ENSMUSG00000053470 UniProt Q9Y4C1 Q6PCM1 RefSeq (mRNA) NM_001146688 NM_018433 NM_001038695 NM_173001 NM_001362200 NM_001362201 RefSeq (protein) NP_001140160 NP_060903 NP_001033784 NP_766589 NP_001349129 NP_001349130 Location (UCSC) Chr 2: 86.44 – 86.49 Mb Chr 6: 71.57 – 71.61 Mb PubMed search [3] [4]
Wikidata
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Lysine demethylase 3A is a protein that in humans is encoded by the KDM3A gene. ^[5]

Function

This gene encodes a zinc finger protein that contains a jumonji C (JmjC) domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants. KDM3A catalyzes the demethylation of H3K9me1 and H3K9me2 residues. Its function is dependent on the presence of cofactors Fe(II) and α-Ketoglutarate. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000115548 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053470 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Lysine demethylase 3A".
6. Yamane K, Toumazou C, Tsukada Y, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y (May 2006). "JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor". Cell. 125 (3): 483–495. doi: 10.1016/j.cell.2006.03.027 . PMID   16603237. S2CID   6643329.

Further reading

• Wellmann S, Bettkober M, Zelmer A, Seeger K, Faigle M, Eltzschig HK, Bührer C (August 2008). "Hypoxia upregulates the histone demethylase JMJD1A via HIF-1". Biochemical and Biophysical Research Communications. 372 (4): 892–897. doi:10.1016/j.bbrc.2008.05.150. PMID   18538129.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.