KREMEN1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | KREMEN1 , KREMEN, KRM1, kringle containing transmembrane protein 1, ECTD13 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 609898 MGI: 1933988 HomoloGene: 12935 GeneCards: KREMEN1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Kremen protein 1 is a protein that in humans is encoded by the KREMEN1 gene. [5] [6] Kremen1 is conserved in chordates including amphioxus [7] and most vertebrate species. [8] The protein is a type I transmembrane receptor of ligands Dickkopf1, [9] Dickkopf2, Dickkopf3, Dickkopf4, EpCAM [10] and Rspondin1.
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular Kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [6]
Kremen1 also has a function in the induction of cell death by apoptosis. [8] This proapototic activity is conditional and depends on the absence of ligand Dickkopf1. [8] These observations led to the classification of this protein as a Dependence Receptor.
A mouse knock out of Kremen1 and its paralog Kremen2 is viable and fertile. [11]
BMP and activin membrane-bound inhibitor homolog , also known as BAMBI, is a protein which in humans is encoded by the BAMBI gene.
Proto-oncogene Wnt-1, or Proto-oncogene Int-1 homolog is a protein that in humans is encoded by the WNT1 gene.
Frizzled-2(Fz-2) is a protein that in humans is encoded by the FZD2 gene.
Frizzled-5(Fz-5) is a protein that in humans is encoded by the FZD5 gene.
Frizzled-6(Fz-6) is a protein that in humans is encoded by the FZD6 gene.
Frizzled-7(Fd-7) is a protein that in humans is encoded by the FZD7 gene.
Frizzled-8(Fz-8) is a protein that in humans is encoded by the FZD8 gene.
Frizzled-9(Fz-9) is a protein that in humans is encoded by the FZD9 gene. Fz-9 has also been designated as CD349.
Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene. It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
Leucine-rich repeat-containing G-protein coupled receptor 6 is a protein that in humans is encoded by the LGR6 gene. Along with the other G-protein coupled receptors LGR4 and LGR5, LGR6 is a Wnt signaling pathway mediator. LGR6 also acts as an epithelial stem cell marker in squamous cell carcinoma in mice in vivo.
Dickkopf-related protein 1 is a protein that in humans is encoded by the DKK1 gene.
Low-density lipoprotein receptor-related protein 6 is a protein that in humans is encoded by the LRP6 gene. LRP6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway.
Dickkopf-related protein 3 is a protein in the Dickkopf family that in humans is encoded by the DKK3 gene.
Protein Wnt-7a is a protein that in humans is encoded by the WNT7A gene.
Wnt inhibitory factor 1 is a protein that in humans is encoded by the WIF1 gene. WIF1 is a lipid-binding protein that binds to Wnt proteins and prevents them from triggering signalling.
Olfactory receptor 2A4 is a protein that in humans is encoded by the OR2A4 gene.
Olfactory receptor 2A1/2A42 is a protein that in humans is encoded by the OR2A1 gene.
Dickkopf-related protein 2 is a protein in the Dickkopf family that in humans is encoded by the DKK2 gene.
Protein Wnt-11 is a protein that in humans is encoded by the WNT11 gene.
Ubiquitin-conjugating enzyme E2 R2 is a protein that in humans is encoded by the UBE2R2 gene.