Kaitlyn Sadtler

Last updated
Kaitlyn Sadtler
Kaitlyn Sadtler headshot.png
NationalityAmerican
Alma mater University of Maryland, Baltimore County (BS)
Johns Hopkins University (PhD)
Known forUS SARS-CoV-2 serosurvey
Scientific career
Fields Immunology
Biomedical engineering
Institutions National Institute of Biomedical Imaging and Bioengineering
Thesis Th2 T-cells are required for biomaterial-mediated functional muscle regeneration  (2016)
Doctoral advisor Jennifer Elisseeff

Kaitlyn Noelle Sadtler is an American immunologist and bioengineer and Stadtman tenure-track Investigator at the National Institute of Biomedical Imaging and Bioengineering, known for her research on immune-active biomaterials for regenerative medicine [1] [2] [3] [4] [5] [6] [7] and for completing the first population-wide serosurvey during the COVID-19 pandemic in the United States in 2020. [8] [9]

Contents

Education

Sadtler attended Urbana High School in Ijamsville, Maryland. [10] She went on to earn her BS in biomedical science summa cum laude at University of Maryland, Baltimore County (UMBC) in 2011. [11] She credits her undergraduate engineering experience with giving her a wide view of the different fields that are foundational to her current work. [12] Sadtler is among a cohort of researchers including Kizzmekia Corbett from UMBC who rose to prominence in the COVID-19 pandemic. [13] [14]

Before starting her PhD, Sadtler held a one-year postbaccalaureate research position at the National Institute of Allergy and Infectious Diseases, where she says she "caught the immunology bug." [8] Sadtler worked in the laboratory of Jennifer Elisseeff at the Johns Hopkins University Cellular and Molecular Medicine program for her PhD, which she completed in only three and a half years, focusing on the molecular mechanisms of medical device fibrosis. [8] [15] Parts of her thesis work were published in journals such as Science and Nature Methods. [15]

Career

Sadtler was a postdoctoral fellow with Robert S. Langer and Daniel Anderson at the Massachusetts Institute of Technology, where she focused on how the modulation of immune response influenced tissue development. [16] [17] During her postdoc, Sadtler was recognized as a TED fellow for her talk "How we could teach our bodies to heal faster." [18] She was also named an inaugural (2018) Convergence Scholar for her work in nanomedicine by the Koch Institute [19] and honored as one of the Forbes 30 Under 30 in 2019 for her doctoral research on immune rejection of medical devices. [20]

SARS-CoV-2 serosurvey

Sadtler organized the first population-wide serosurvey for COVID-19 in the United States, considered critical in developing an understanding of asymptomatic transmission rates. [21] From April to July 2020, her group and collaborators enrolled 10,000 representative volunteers to mail in dry blood samples for testing by ELISA. [22] [23] Initial testing of those samples was completed by the end of September. [12] Sadtler's team was able to sample a representative portion of the US population in part thanks to the overwhelming response of more than 400,000 volunteers for participation. [24] The initial analysis, released as a preprint in early 2021, indicated that there may have been as many as 4.8 unreported infections for each documented infection early in the pandemic, or up to 16.8 million undiagnosed infection. [25] [26] [27] Results also supported that black and Hispanic communities have been most affected by the virus. [28] Although the study is still undergoing peer-review, Sadtler explained her hopes for eventual follow-up to assess both antibody duration and reinfection frequency. [22] [29]

Related Research Articles

<span class="mw-page-title-main">Tejal A. Desai</span> American Nanotechnologist (born 1972)

Tejal Ashwin Desai is Sorensen Family Dean of Engineering at Brown University. Prior to joining Brown, she was the Deborah Cowan Endowed Professor in the Department of Bioengineering and Therapeutic Sciences at University of California, San Francisco, Director of the Health Innovations via Engineering Initiative (HIVE), and head of the Therapeutic Micro and Nanotechnology Laboratory. She was formerly an associate professor at Boston University (2002–06) and an assistant professor at University of Illinois at Chicago (1998–2001). She is a researcher in the area of therapeutic micro and nanotechnology and has authored and edited at least one book on the subject and another on biomaterials.

<span class="mw-page-title-main">La Jolla Institute for Immunology</span> Research institute near San Diego, California, U.S.

La Jolla Institute for Immunology (LJI) is a non-profit research organization in La Jolla, a community of San Diego, California. The institute was founded in 1988. It is located in UC San Diego’s Research Park. The institute researches immunology and immune system diseases. The institute employs 220 M.D.s and Ph.D.s, including 23 faculty members and more than 450 employees. Dr. Erica Ollmann Saphire has served as its president and CEO since 2021.

<span class="mw-page-title-main">Linda Griffith</span> American biological engineer

Linda Gay Griffith is an American biological engineer, and Professor of Biological Engineering and Mechanical Engineering at Massachusetts Institute of Technology, where she also directs the Center for Gynepathology Research.

Kristi S. Anseth is the Tisone Distinguished Professor of Chemical and Biological Engineering, an Associate Professor of Surgery, and a Howard Hughes Medical Investigator at the University of Colorado at Boulder. Her main research interests are the design of synthetic biomaterials using hydrogels, tissue engineering, and regenerative medicine.

<span class="mw-page-title-main">Gordana Vunjak-Novakovic</span> Serbian American engineer

Gordana Vunjak-NovakovicFRSC is a Serbian American biomedical engineer and university professor. She is a University Professor at Columbia University, as well as the Mikati Foundation Professor of Biomedical Engineering and Medical Sciences. She also heads the laboratory for Stem Cells and Tissue Engineering at Columbia University. She is part of the faculty at the Irving Comprehensive Cancer Center and the Center for Human Development, both found at Columbia University. She is also an honorary professor at the Faculty of Technology and Metallurgy at the University of Belgrade, an honorary professor at the University of Novi Sad, and an adjunct professor at the Department of Biomedical Engineering at Tufts University.

Treena Livingston Arinzeh is an American biomedical engineer and academic.

<span class="mw-page-title-main">Antonios Mikos</span> Greek-American biomedical engineer

Antonios Georgios Mikos is a Greek-American biomedical engineer who is the Louis Calder Professor of Bioengineering and Chemical and Biomolecular Engineering at Rice University. He specialises in biomaterials, drug delivery, and tissue engineering.

<span class="mw-page-title-main">Jennifer Elisseeff</span> Professor of biomedical engineering

Jennifer Hartt Elisseeff is an American biomedical engineer, ophthalmologist and academic. She is the Morton Goldberg Professor and Director of the Translational Tissue Engineering Center at Johns Hopkins Department of Biomedical Engineering and the Wilmer Eye Institute with appointments in Chemical Engineering, Biomedical Engineering, Materials Science and Orthopedic Surgery. Elisseeff's research is in the fields of regenerative medicine and immunoengineering.

<span class="mw-page-title-main">Akhilesh K. Gaharwar</span> Indian biomedical engineering researcher (born 1982)

Akhilesh K. Gaharwar is an Indian academic and a professor in the Department of Biomedical Engineering at Texas A&M University.

<span class="mw-page-title-main">Giuseppe Scionti</span> Italian technology entrepreneur and researcher

Giuseppe Scionti is a technology entrepreneur, inventor, and researcher in the fields of bioengineering and food tech. He is the founder and CEO of Novameat. In 2018 and 2019, he was featured by international mass media as the inventor of the world's first 3D printed plant-based meat substitute.

<span class="mw-page-title-main">Erin Lavik</span> American material scientist

Erin Baker Lavik is an American bioengineer serving as the deputy director and chief technology officer of the National Cancer Institute's Division of Cancer Prevention (DCP) since 2023. She was previously a professor of chemical, biochemical, and environmental engineering at the University of Maryland, Baltimore County. Lavik develops polymers and nanoparticles that can protect the nervous system. She is a fellow of the American Institute for Medical and Biological Engineering.

<span class="mw-page-title-main">Kafui Dzirasa</span> American psychiatrist and academic

Kafui Dzirasa is an American psychiatrist and Associate Professor at Duke University. He looks to understand the relationship between neural circuit malfunction and mental illness. He was a 2019 AAAS Leshner Fellow and was elected Fellow of the National Academy of Medicine in 2021.

<span class="mw-page-title-main">Kizzmekia Corbett</span> American immunologist

Kizzmekia "Kizzy" Shanta Corbett is an American viral immunologist. She is an Assistant Professor of Immunology and Infectious Diseases at Harvard T.H. Chan School of Public Health and the Shutzer Assistant Professor at the Harvard Radcliffe Institute since June 2021.

<span class="mw-page-title-main">Debra Auguste</span> American chemical engineer

Debra Auguste is an American chemical engineer and professor at Northeastern University in the department of chemical engineering. Auguste is dedicated to developing treatments for triple negative breast cancer, one of the most aggressive and fatal cancers that disproportionately affects African American women. Her lab characterizes biomarkers of triple negative breast cancer and develops novel biocompatible therapeutic technologies to target and destroy metastatic cancer cells. Auguste received the 2012 Presidential Early Career Award for Scientists and Engineers and in 2010 was named in the 50 Most Influential African-Americans in Technology. In 2020, Auguste became an Elected Fellow of the American Institute for Medical and Biological Engineering.

Shelly R. Peyton is an American chemical engineer who is the Armstrong Professional Development Professor in the Department of CHemical Engineering at the University of Massachusetts Amherst. Her research considers the development of biomaterials to investigate metastatic cancer and potential new therapies.

Helen Haiyan Lu is a Chinese American biomedical engineer and the Percy K. and Vida L. W. Hudson professor of biomedical engineering at the Columbia University Fu Foundation School of Engineering and Applied Science. Her work focuses on understanding and developing therapies in complex tissue systems, especially the interface between soft tissue and bone.

Jeffrey Alan Hubbell is an American bioengineering working immunoengineering. His research has focused on topics from physical biology, biomaterials, regenerative medicine, and translational immunology.

Catherine M. Klapperich is an American biomedical engineer noted for her research on diagnostics and precision medicine. She is currently professor of biomedical engineering at Boston University, with additional appointments in materials science & engineering and mechanical engineering. Klapperich serves as the director of research for the DAMP Laboratory at BU. Klapperich was previously the director of the NIH NIBIB Center for Future Technologies in Cancer Care as part of the Point-of Care-Research Technologies Network.

Tatiana Segura is an American biomedical engineer who is a professor at Duke University. Her research considers biomedical engineering solutions to promote cell growth. She was elected Fellow of the American Institute for Medical and Biological Engineering in 2017 and awarded the Acta Biomaterialia Silver Medal in 2021.

<span class="mw-page-title-main">Karen Christman</span> American bioengineer and academic

Karen Leigh Christman is an American bioengineer who is the Associate Dean for Faculty Affairs and the Pierre Galletti Endowed Chair for Bioengineering Innovation at University of California, San Diego. Her research considers regenerative medicine and tissue engineering. She was elected a Fellow of the National Academy of Inventors in 2023.

References

  1. "Kaitlyn Sadtler, Ph.D. | Principal Investigators | NIH Intramural Research Program". irp.nih.gov. Retrieved 2024-10-23.
  2. Sadtler, Kaitlyn. "Kaitlyn Sadtler | Speaker | TED". www.ted.com. Retrieved 2024-10-23.
  3. Sadtler, Kaitlyn; Estrellas, Kenneth; Allen, Brian W.; Wolf, Matthew T.; Fan, Hongni; Tam, Ada J.; Patel, Chirag H.; Luber, Brandon S.; Wang, Hao; Wagner, Kathryn R.; Powell, Jonathan D.; Housseau, Franck; Pardoll, Drew M.; Elisseeff, Jennifer H. (2016-04-15). "Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells". Science. 352 (6283): 366–370. doi:10.1126/science.aad9272. ISSN   0036-8075. PMC   4866509 . PMID   27081073.
  4. Sadtler, Kaitlyn; Wolf, Matthew T.; Ganguly, Sudipto; Moad, Christopher A.; Chung, Liam; Majumdar, Shoumyo; Housseau, Franck; Pardoll, Drew M.; Elisseeff, Jennifer H. (2019-02-01). "Divergent immune responses to synthetic and biological scaffolds". Biomaterials. 192: 405–415. doi:10.1016/j.biomaterials.2018.11.002. ISSN   0142-9612.
  5. Sadtler, Kaitlyn; Singh, Anirudha; Wolf, Matthew T.; Wang, Xiaokun; Pardoll, Drew M.; Elisseeff, Jennifer H. (2016-06-07). "Design, clinical translation and immunological response of biomaterials in regenerative medicine". Nature Reviews Materials. 1 (7): 1–17. doi:10.1038/natrevmats.2016.40. ISSN   2058-8437.
  6. Sadtler, Kaitlyn; Allen, Brian W.; Estrellas, Kenneth; Housseau, Franck; Pardoll, Drew M.; Elisseeff, Jennifer H. (October 2017). "The Scaffold Immune Microenvironment: Biomaterial-Mediated Immune Polarization in Traumatic and Nontraumatic Applications". Tissue Engineering Part A. 23 (19–20): 1044–1053. doi:10.1089/ten.tea.2016.0304. ISSN   1937-3341. PMC   6436021 . PMID   27736323.
  7. Sadtler, Kaitlyn; Sommerfeld, Sven D.; Wolf, Matthew T.; Wang, Xiaokun; Majumdar, Shoumyo; Chung, Liam; Kelkar, Dhanashree S.; Pandey, Akhilesh; Elisseeff, Jennifer H. (2017-02-01). "Proteomic composition and immunomodulatory properties of urinary bladder matrix scaffolds in homeostasis and injury". Seminars in Immunology. SI: Innate immunity and biologic scaffolds. 29: 14–23. doi:10.1016/j.smim.2017.05.002. ISSN   1044-5323. PMC   8509637 .
  8. 1 2 3 "Engineering tissues and a new science culture | National Institute of Biomedical Imaging and Bioengineering". www.nibib.nih.gov. Retrieved 2021-03-19.
  9. DeVille, Taylor. "Almost 17 million U.S. coronavirus cases were not detected during first half of 2020, study led by UMBC graduate finds". baltimoresun.com. Retrieved 2021-03-19.
  10. Lynn, Kellye (2020-05-18). "Former Frederick County student researching COVID-19 antibodies at NIH". WJLA. Retrieved 2021-03-19.
  11. "Meet Dr. Kaitlyn Sadtler, an immunoengineer working on how our body's defense system can help build new tissue!". The female Scientist. 2018-02-25. Retrieved 2021-03-19.
  12. 1 2 Hansen, Sarah (2020-11-17). "Chasing Antibodies". UMBC Magazine. Retrieved 2021-03-19.
  13. Dzirasa, Letitia Dzirasa, Delali. "It's time to expand affordable high-quality higher ed at places like UMBC that have a proven track | COMMENTARY". baltimoresun.com. Retrieved 2021-03-19.{{cite web}}: CS1 maint: multiple names: authors list (link)
  14. Hrabowski, Freeman A.; Tracy, J. Kathleen; Henderson, Peter H. (2020-08-04). "Opinion: At a Crossroads: Reimagining science, engineering, and medicine—and its practitioners". Proceedings of the National Academy of Sciences. 117 (31): 18137–18141. doi: 10.1073/pnas.2013588117 . ISSN   0027-8424. PMC   7414165 . PMID   32669431.
  15. 1 2 "Kaitlyn Sadtler | National Institute of Biomedical Imaging and Bioengineering". www.nibib.nih.gov. Retrieved 2021-03-19.
  16. "Publications: 2011 – 2020 – Langer Lab" . Retrieved 2021-03-19.
  17. "Kaitlyn Sadtler". The Marble Center for Cancer Nanomedicine. Retrieved 2021-03-19.
  18. Sadtler, Kaitlyn, How we could teach our bodies to heal faster , retrieved 2021-03-19
  19. "Preparing postdocs for life beyond the bench". MIT News | Massachusetts Institute of Technology. Retrieved 2021-03-19.
  20. "Kaitlyn Sadtler". Forbes. Retrieved 2021-03-19.
  21. Rosenbaum, Leah. "This 30 Under 30 Alum Is Figuring Out How Many People Already Have Immunity Against Coronavirus". Forbes. Retrieved 2021-03-19.
  22. 1 2 DeVille, Taylor. "Almost 17 million U.S. coronavirus cases were not detected during first half of 2020, study led by UMBC graduate finds". baltimoresun.com. Retrieved 2021-03-19.
  23. Albert, Mark (2020-04-16), Want to know if you have immunity from the coronavirus? A new study seeks volunteers , retrieved 2021-03-19
  24. Perera, Katryna. "Kaitlyn Sadtler: FCPS grad turned COVID-19 researcher". The Frederick News-Post. Retrieved 2021-03-19.
  25. Kalish, Heather; Klumpp-Thomas, Carleen; Hunsberger, Sally; Baus, Holly Ann; Fay, Michael P.; Siripong, Nalyn; Wang, Jing; Hicks, Jennifer; Mehalko, Jennifer; Travers, Jameson; Drew, Matthew (2021-01-31). "Mapping a Pandemic: SARS-CoV-2 Seropositivity in the United States". medRxiv   10.1101/2021.01.27.21250570 .
  26. Times, Amina Khan, Los Angeles. "Pandemic's reach far outstripped official coronavirus case counts, study suggests". Finger Lakes Times. Retrieved 2021-03-19.{{cite web}}: CS1 maint: multiple names: authors list (link)
  27. "Millions of coronavirus cases likely went undiagnosed". CBS News . 2021-02-22. Retrieved 6 November 2024.
  28. "Biden striving for return to normalcy by end of year | Health and Science | Journal Gazette". www.journalgazette.net. Retrieved 2021-03-19.
  29. Rosenbaum, Leah. "Researchers Estimate There Were 17 Million Undiagnosed Cases Of Covid-19 Last Summer". Forbes. Retrieved 2021-03-19.