Kaitlyn Sadtler

Last updated
Kaitlyn Sadtler
Kaitlyn Sadtler headshot.png
NationalityAmerican
Alma mater University of Maryland, Baltimore County (BS)
Johns Hopkins University (PhD)
Known forUS SARS-CoV-2 serosurvey
Scientific career
Fields Immunology
Biomedical engineering
Institutions National Institute of Biomedical Imaging and Bioengineering
Thesis Th2 T-cells are required for biomaterial-mediated functional muscle regeneration  (2016)
Doctoral advisor Jennifer Elisseeff

Kaitlyn Noelle Sadtler is an American immunologist and bioengineer and Stadtman Tenure-Track Investigator at the National Institute of Biomedical Imaging and Bioengineering, known for completing the first population-wide serosurvey during the COVID-19 pandemic in the United States in 2020. [1] [2]

Contents

Education

Sadtler attended Urbana High School in Ijamsville, Maryland. [3] She went on to earn her BS in biomedical science summa cum laude at University of Maryland, Baltimore County (UMBC) in 2011. [4] She credits her undergraduate engineering experience with giving her a wide view of the different fields that are foundational to her current work. [5] Sadtler is among a cohort of researchers including Kizzmekia Corbett from UMBC who rose to prominence in the COVID-19 pandemic. [6] [7]

Before starting her PhD, Sadtler held a one-year postbaccalaureate research position at the National Institute of Allergy and Infectious Diseases, where she says she "caught the immunology bug." [1] Sadtler worked in the laboratory of Jennifer Elisseeff at the Johns Hopkins University Cellular and Molecular Medicine program for her PhD, which she completed in only three and a half years, focusing on the molecular mechanisms of medical device fibrosis. [1] [8] Parts of her thesis work were published in journals such as Science and Nature Methods. [8]

Career

Sadtler was a postdoctoral fellow with Robert S. Langer and Daniel Anderson at the Massachusetts Institute of Technology, where she focused on how the modulation of immune response influenced tissue development. [9] [10] During her postdoc, Sadtler was recognized as a TED fellow for her talk "How we could teach our bodies to heal faster." [11] She was also named an inaugural (2018) Convergence Scholar for her work in nanomedicine by the Koch Institute [12] and honored as one of the Forbes 30 Under 30 in 2019 for her doctoral research on immune rejection of medical devices. [13]

SARS-CoV-2 serosurvey

Sadtler organized the first population-wide serosurvey for COVID-19 in the United States, considered critical in developing an understanding of asymptomatic transmission rates. [14] From April to July 2020, her group and collaborators enrolled 10,000 representative volunteers to mail in dry blood samples for testing by ELISA. [15] [16] Initial testing of those samples was completed by the end of September. [5] Sadtler's team was able to sample a representative portion of the US population in part thanks to the overwhelming response of more than 400,000 volunteers for participation. [17] The initial analysis, released as a preprint in early 2021, indicated that there may have been as many as 4.8 unreported infections for each documented infection early in the pandemic, or up to 16.8 million undiagnosed infection. [18] [19] [20] Results also supported that black and Hispanic communities have been most affected by the virus. [21] Although the study is still undergoing peer-review, Sadtler explained her hopes for eventual follow-up to assess both antibody duration and reinfection frequency. [15] [22]

Related Research Articles

<span class="mw-page-title-main">National Institute of Biomedical Imaging and Bioengineering</span> Component of the U.S. National Institutes of Health

The National Institute of Biomedical Imaging and Bioengineering (NIBIB), founded at the National Institutes of Health (NIH) in 2000, is located in Bethesda, Maryland. It is one of 27 institutes and centers that are part of NIH, an agency of the U.S. Department of Health and Human Services (HHS).

<span class="mw-page-title-main">Sunetra Gupta</span> British novelist and epidemiologist

Sunetra Gupta is an Indian-born British infectious disease epidemiologist and a professor of theoretical epidemiology at the Department of Zoology, University of Oxford. She has performed research on the transmission dynamics of various infectious diseases, including malaria, influenza and COVID-19, and has received the Scientific Medal of the Zoological Society of London and the Rosalind Franklin Award of the Royal Society. She is a member of the scientific advisory board of Collateral Global, an organisation which examines the global impact of COVID-19 restrictions.

<span class="mw-page-title-main">La Jolla Institute for Immunology</span>

La Jolla Institute for Immunology is a non-profit research organization located in La Jolla, San Diego, California. It is located in UC San Diego’s Research Park. The institute researches immunology and immune system diseases. The institute employs 220 M.D.s and Ph.D.s, including 23 faculty members and more than 450 employees. Dr. Mitchell Kronenberg has served as its president and scientific director since 2003. The institute was founded in 1988.

<span class="mw-page-title-main">Vaccine Research Center</span>

The Vaccine Research Center (VRC), is an intramural division of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), US Department of Health and Human Services (HHS). The mission of the VRC is to discover and develop both vaccines and antibody-based products that target infectious diseases.

<span class="mw-page-title-main">Akiko Iwasaki</span> Immunobiologist

Akiko Iwasaki is a Sterling Professor of Immunobiology and Molecular, Cellular and Developmental Biology at Yale University. She is also a principal investigator at the Howard Hughes Medical Institute. Her research interests include innate immunity, autophagy, inflammasomes, sexually transmitted infections, herpes simplex virus, human papillomavirus, respiratory virus infections, influenza infection, T cell immunity, commensal bacteria, COVID-19 and Long COVID.

<span class="mw-page-title-main">Wuhan Institute of Virology</span> Research Institute in Wuhan, Hubei, China

The Wuhan Institute of Virology, Chinese Academy of Sciences is a research institute on virology administered by the Chinese Academy of Sciences (CAS), which reports to the State Council of the People's Republic of China. The institute is one of nine independent organisations in the Wuhan Branch of the CAS. Located in Jiangxia District, Wuhan, Hubei, it was founded in 1956 and opened mainland China's first biosafety level 4 (BSL-4) laboratory in 2018. The institute has collaborated with the Galveston National Laboratory in the United States, the Centre International de Recherche en Infectiologie in France, and the National Microbiology Laboratory in Canada. The institute has been an active premier research center for the study of coronaviruses.

AbCellera Biologics Inc. is a Vancouver, British Columbia-based biotechnology firm that researches and develops human antibodies. The company is best known for its leading role in the Pandemic Prevention Platform, a project of DARPA's Biological Technologies Office. AbCellera utilizes a proprietary technology platform, which they claim can develop "medical countermeasures within 60 days." Its platform for single-cell screening was initially developed at the University of British Columbia.

<span class="mw-page-title-main">Kizzmekia Corbett</span> American immunologist

Kizzmekia "Kizzy" Shanta Corbett is an American viral immunologist. She is an Assistant Professor of Immunology and Infectious Diseases at Harvard T.H. Chan School of Public Health and the Shutzer Assistant Professor at the Harvard Radcliffe Institute since June 2021.

<span class="mw-page-title-main">Angela Rasmussen</span> American virologist and researcher

Angela Lynn Rasmussen is an American virologist at the Vaccine and Infectious Disease Organization at the University of Saskatchewan in Canada.

<span class="mw-page-title-main">Peter Daszak</span> British zoologist

Peter Daszak is a British zoologist, consultant and public expert on disease ecology, in particular on zoonosis. He is the president of EcoHealth Alliance, a nonprofit non-governmental organization that supports various programs on global health and pandemic prevention. He is also a member of the Center for Infection and Immunity at the Columbia University Mailman School of Public Health. He lives in Suffern, New York.

Natalie E. Dean is an American biostatistician specializing in infectious disease epidemiology. Dean is currently an assistant professor of Biostatistics at the University of Florida. Her research involves epidemiological modeling of outbreaks, including Ebola, Zika and COVID-19.

Mirela Delibegovic is a British pharmacologist/biochemist who is Dean for Industrial Engagement in Research & Knowledge Transfer and Director of Aberdeen Cardiovascular and Diabetes Centre. She holds a Personal Chair in Diabetes Physiology and Signalling at the Institute of Medical Sciences at the University of Aberdeen. During the COVID-19 pandemic, Delibegovic used artificial intelligence to develop technologies that would allow mass-screening for coronavirus disease 2019.

Catherine Blish is a translational immunologist and professor at Stanford University. Her lab works on clinical immunology and focuses primarily on the role of the innate immune system in fighting infectious diseases like HIV, dengue fever, and influenza. Her immune cell biology work characterizes the biology and action of Natural Killer (NK) cells and macrophages.

<span class="mw-page-title-main">Hilary D. Marston</span> American physician-scientist and policy advisor

Hilary D. Marston is an American physician-scientist and global health policy advisor specializing in pandemic preparedness. She is the Chief Medical Officer of the Food and Drug Administration.

Michael Joseph Mina is an American epidemiologist, immunologist and physician. He was formerly an assistant professor of Epidemiology & Immunology and Infectious Diseases at Harvard T.H. Chan School of Public Health, assistant Professor of Pathology at Brigham and Women's Hospital, Harvard Medical School, and currently Chief Medical Officer at eMed.

Nita K. Patel is an Indian-American vaccinologist who leads vaccine development at Novavax. She oversaw the development of the Novavax COVID-19 vaccine.

<span class="mw-page-title-main">Sara Sawyer</span>

Dr. Sara Lea Sawyer is a professor at the University of Colorado Boulder. She has received national and international prizes in virology. In 2011 she was as awarded the Presidential Early Career Award for Scientists and Engineers (PECASE) by President Barack Obama at the White House. She serves as a Senior Editor at the journal eLIFE, and as a government consultant on the topic of pandemic preparedness. In 2020, she co-founded Darwin Biosciences, an infectious disease diagnostics company located in Boulder, Colorado. In 2022, she was awarded the National Institutes of Health Director’s “Pioneer” award. Her research focuses on animal viruses that infect humans, including HIV-1, and the evolution of the immune system.

<span class="mw-page-title-main">John R. Mascola</span> American Physician-Scientist

John R. Mascola is an American physician-scientist, immunologist and infectious disease specialist. He was the director of the Vaccine Research Center (VRC), part of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH). He also served as a principal advisor to Anthony Fauci, director of NIAID, on vaccines and biomedical research affairs. Mascola is the current Chief Scientific Officer for ModeX Therapeutics.

Catherine M. Klapperich is an American biomedical engineer noted for her research on diagnostics and precision medicine. She is currently professor of biomedical engineering at Boston University, with additional appointments in materials science & engineering and mechanical engineering. Klapperich serves as the director of research for the DAMP Laboratory at BU. Klapperich was previously the director of the NIH NIBIB Center for Future Technologies in Cancer Care as part of the Point-of Care-Research Technologies Network.

References

  1. 1 2 3 "Engineering tissues and a new science culture | National Institute of Biomedical Imaging and Bioengineering". www.nibib.nih.gov. Retrieved 2021-03-19.
  2. ↑ DeVille, Taylor. "Almost 17 million U.S. coronavirus cases were not detected during first half of 2020, study led by UMBC graduate finds". baltimoresun.com. Retrieved 2021-03-19.
  3. ↑ Lynn, Kellye (2020-05-18). "Former Frederick County student researching COVID-19 antibodies at NIH". WJLA. Retrieved 2021-03-19.
  4. ↑ "Meet Dr. Kaitlyn Sadtler, an immunoengineer working on how our body's defense system can help build new tissue!". The female Scientist. 2018-02-25. Retrieved 2021-03-19.
  5. 1 2 Hansen, Sarah (2020-11-17). "Chasing Antibodies". UMBC Magazine. Retrieved 2021-03-19.
  6. ↑ Dzirasa, Letitia Dzirasa, Delali. "It's time to expand affordable high-quality higher ed at places like UMBC that have a proven track | COMMENTARY". baltimoresun.com. Retrieved 2021-03-19.{{cite web}}: CS1 maint: multiple names: authors list (link)
  7. ↑ Hrabowski, Freeman A.; Tracy, J. Kathleen; Henderson, Peter H. (2020-08-04). "Opinion: At a Crossroads: Reimagining science, engineering, and medicine—and its practitioners". Proceedings of the National Academy of Sciences. 117 (31): 18137–18141. doi: 10.1073/pnas.2013588117 . ISSN   0027-8424. PMC   7414165 . PMID   32669431.
  8. 1 2 "Kaitlyn Sadtler | National Institute of Biomedical Imaging and Bioengineering". www.nibib.nih.gov. Retrieved 2021-03-19.
  9. ↑ "Publications: 2011 – 2020 – Langer Lab" . Retrieved 2021-03-19.
  10. ↑ "Kaitlyn Sadtler". The Marble Center for Cancer Nanomedicine. Retrieved 2021-03-19.
  11. ↑ Sadtler, Kaitlyn, How we could teach our bodies to heal faster , retrieved 2021-03-19
  12. ↑ "Preparing postdocs for life beyond the bench". MIT News | Massachusetts Institute of Technology. Retrieved 2021-03-19.
  13. ↑ "Kaitlyn Sadtler". Forbes. Retrieved 2021-03-19.
  14. ↑ Rosenbaum, Leah. "This 30 Under 30 Alum Is Figuring Out How Many People Already Have Immunity Against Coronavirus". Forbes. Retrieved 2021-03-19.
  15. 1 2 DeVille, Taylor. "Almost 17 million U.S. coronavirus cases were not detected during first half of 2020, study led by UMBC graduate finds". baltimoresun.com. Retrieved 2021-03-19.
  16. ↑ Albert, Mark (2020-04-16), Want to know if you have immunity from the coronavirus? A new study seeks volunteers , retrieved 2021-03-19
  17. ↑ Perera, Katryna. "Kaitlyn Sadtler: FCPS grad turned COVID-19 researcher". The Frederick News-Post. Retrieved 2021-03-19.
  18. ↑ Kalish, Heather; Klumpp-Thomas, Carleen; Hunsberger, Sally; Baus, Holly Ann; Fay, Michael P.; Siripong, Nalyn; Wang, Jing; Hicks, Jennifer; Mehalko, Jennifer; Travers, Jameson; Drew, Matthew (2021-01-31). "Mapping a Pandemic: SARS-CoV-2 Seropositivity in the United States". medRxiv   10.1101/2021.01.27.21250570 .
  19. ↑ Times, Amina Khan, Los Angeles. "Pandemic's reach far outstripped official coronavirus case counts, study suggests". Finger Lakes Times. Retrieved 2021-03-19.{{cite web}}: CS1 maint: multiple names: authors list (link)
  20. ↑ "Millions of coronavirus cases likely went undiagnosed". CBS News . 2021-02-22. Retrieved 27 September 2023.
  21. ↑ "Biden striving for return to normalcy by end of year | Health and Science | Journal Gazette". www.journalgazette.net. Retrieved 2021-03-19.
  22. ↑ Rosenbaum, Leah. "Researchers Estimate There Were 17 Million Undiagnosed Cases Of Covid-19 Last Summer". Forbes. Retrieved 2021-03-19.
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