Karmella Haynes

Last updated
Karmella Haynes
Born
St. Louis, Missouri, U.S.
Alma mater Washington University in St. Louis Ph.D (2006)
Florida A&M University B.S. (1999)
Known forChromatin, Synthetic Biology, Epigenetics, Cancer
Awards
Scientific career
Institutions
Thesis  (2006)
Doctoral advisor Sarah Elgin
Website khayneslab.wordpress.com

Karmella Ann Haynes is a biomedical engineer and associate professor at the Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University. [1] [2] She researches how chromatin is used to control cell development in biological tissue.

Contents

Early life and education

Haynes was born and raised in St. Louis. [3] She received her B.S. in biology from Florida A&M University (where she had received a full scholarship) in 1999 . [4] [5] While at Florida A&M, she participated in a summer research program working with Mary-Lou Pardue at Massachusetts Institute of Technology as part of the MIT Summer Research Program. [6] [7] [8]

Haynes did her graduate work in the lab of Sarah Elgin at Washington University in St. Louis. [4] [6] She received her Ph.D. in molecular genetics in 2006 for her work studying chromatin dynamics and epigenetics in Drosophila. [9] [10] [11] [12]

As a Howard Hughes Medical Institute fellow, she completed her first postdoctoral fellowship in teaching at Davidson College under the guidance of Laurie Heyer and Malcolm Campbell. [4] [5] During her time as a fellow, Haynes redesigned the undergraduate bioinformatics teaching course and won publication of the year from the Journal of Biological Engineering for her article Engineering bacteria to solve the Burnt Pancake Problem. [13] [14] [15] [16] [17] She was introduced to synthetic biology and became a member of Davidson's 2006 iGEM team. [18]

Haynes went on to complete a second postdoctoral fellowship in Pamela Silver's lab at Harvard Medical School where she leveraged her experience with chromatin dynamics and synthetic biology to create artificial transcription factors which activated genes based on histone methylation. [6] [19] [12]

Academic career and research

After her postdoctoral fellowships in 2011, Haynes started her lab in the School of Biological and Health Systems Engineering at Arizona State University (ASU). [20] [21] There, her lab focused on creating epigenetic machinery that can regulate DNA. [22] The proteins themselves are fusion transcription factors, which can target particular genes. [23] She hopes to increase the use of technology in therapeutics, working on tissue regeneration and customizable protein-based drugs. [24] In 2015 she was awarded a K01 grant to study the use of modular peptide motifs to build synthetic chromatin proteins that activate dormant therapeutic genes. [25] During her time at ASU, she was the faculty advisor for the ASU iGEM team. [26]

In 2018, Haynes moved to the W.H. Coulter Biomedical Engineering Department at Georgia Tech/Emory University. [27] [5] During her time here, she founded the AfroBiotech conference and the Cold Spring Harbor Summer Course on Synthetic Biology. [28] [29] She was on the responsible conduct committee for IGEM in 2018 and 2019. [30] [31]

Public engagement

Haynes has appeared on PBS, talking about biotechnology and disease. [32] Alongside research, Haynes is an accomplished artist. [33] [34] In 2011, she painted her poster presentation for the Fifth International Meeting of Synthetic Biology (SB5.0) conference. [35] Her artwork is still on the walls at Harvard University. [6] She is a member of the Building with Biology public engagement project. [36] She has been featured twice on Science Friday. [37]

Awards and honors

Professional memberships

Notable papers

As of August 16, 2020 based on Google Scholar citations:

Related Research Articles

Pamela Ann Silver is an American cell and systems biologist and a bioengineer. She holds the Elliot T. and Onie H. Adams Professorship of Biochemistry and Systems Biology at Harvard Medical School in the Department of Systems Biology. Silver is one of the founding Core Faculty Members of the Wyss Institute for Biologically Inspired Engineering at Harvard University.

Chromatin remodeling is the dynamic modification of chromatin architecture to allow access of condensed genomic DNA to the regulatory transcription machinery proteins, and thereby control gene expression. Such remodeling is principally carried out by 1) covalent histone modifications by specific enzymes, e.g., histone acetyltransferases (HATs), deacetylases, methyltransferases, and kinases, and 2) ATP-dependent chromatin remodeling complexes which either move, eject or restructure nucleosomes. Besides actively regulating gene expression, dynamic remodeling of chromatin imparts an epigenetic regulatory role in several key biological processes, egg cells DNA replication and repair; apoptosis; chromosome segregation as well as development and pluripotency. Aberrations in chromatin remodeling proteins are found to be associated with human diseases, including cancer. Targeting chromatin remodeling pathways is currently evolving as a major therapeutic strategy in the treatment of several cancers.

<span class="mw-page-title-main">Caroline Dean</span> British botanist

Dame Caroline Dean is a British plant scientist working at the John Innes Centre. She is focused on understanding the molecular controls used by plants to seasonally judge when to flower. She is specifically interested in vernalisation — the acceleration of flowering in plants by exposure to periods of prolonged cold. She has also been on the Life Sciences jury for the Infosys Prize from 2018.

Cellular memory modules are a form of epigenetic inheritance that allow cells to maintain their original identity after a series of cell divisions and developmental processes. Cellular memory modules implement these preserved characteristics into transferred environments through transcriptional memory. Cellular memory modules are primarily found in Drosophila.

<span class="mw-page-title-main">Sarah Elgin</span> American biologist

Sarah C.R. Elgin is an American biochemist and geneticist. She is the Viktor Hamburger Professor of biology at Washington University in St. Louis, and is noted for her work in epigenetics, gene regulation, and heterochromatin, and for her contributions to science education.

<span class="mw-page-title-main">Epigenome editing</span>

Epigenome editing or epigenome engineering is a type of genetic engineering in which the epigenome is modified at specific sites using engineered molecules targeted to those sites. Whereas gene editing involves changing the actual DNA sequence itself, epigenetic editing involves modifying and presenting DNA sequences to proteins and other DNA binding factors that influence DNA function. By "editing” epigenomic features in this manner, researchers can determine the exact biological role of an epigenetic modification at the site in question.

<i>Epigenetics & Chromatin</i> Academic journal

Epigenetics & Chromatin is a peer-reviewed open access scientific journal published by BioMed Central that covers the biology of epigenetics and chromatin.

<span class="mw-page-title-main">Robin Allshire</span>

Robin Campbell Allshire is Professor of Chromosome Biology at University of Edinburgh and a Wellcome Trust Principal Research Fellow. His research group at the Wellcome Trust Centre for Cell Biology focuses on the epigenetic mechanisms governing the assembly of specialised domains of chromatin and their transmission through cell division.

<span class="mw-page-title-main">Christina Agapakis</span> American biologist

Christina Maria Agapakis is a synthetic biologist, science writer. She is the Creative Director of the biotechnology company Ginkgo Bioworks.

Asifa Akhtar is a Pakistani biologist who has made significant contributions to the field of chromosome regulation. She is Senior Group Leader and Director of the Department of Chromatin Regulation at the Max Planck Institute of Immunobiology and Epigenetics. Akhtar was awarded EMBO membership in 2013. She became the first international and female Vice President of the Max Planck Society's Biology and Medicine Section in July 2020.

Melissa A. Wilson is an evolutionary and computational biologist and assistant professor at Arizona State University who studies the evolution of sex chromosomes.

<span class="mw-page-title-main">Diana Hargreaves</span> American biologist

Diana Hargreaves is an American biologist and assistant professor at The Salk Institute for Biological Studies and member of The Salk Cancer Center. Her laboratory focuses on epigenetic regulation by the BAF (SWI/SNF) chromatin remodeling complexes in diverse physiological processes including development, immunity, and diseases such as cancer.

<span class="mw-page-title-main">Isabelle Mansuy</span> Neuroscientist

Isabelle M. Mansuy is a professor in neuroepigenetics in the Medical Faculty of the University of Zurich and the Department of Health Science and Technology of the Swiss Federal Institute of Technology Zurich. She is known for her work on the mechanisms of epigenetic inheritance in relation to childhood trauma.

<span class="mw-page-title-main">Farah Lubin</span> American neuroscientist

Farah D. Lubin is an American neuroscientist and Professor of Neurobiology and Cell, Developmental, and Integrative Biology at the University of Alabama at Birmingham within the Heersink School of Medicine. Lubin is the Principal Investigator of the Lubin Lab which explores the epigenetic mechanisms underlying cognition and how these mechanisms are altered in disease states such as epilepsy and neurodegeneration. Lubin discovered the role of NF-κB in fear memory reconsolidation and also uncovered a novel role for epigenetic regulation of BDNF during long-term memory formation and in epilepsy leading to memory loss. Lubin is a champion for diversity at UAB as the Director of the Roadmap Scholar Program and as a faculty mentor for several institutional and national programs to increase retention of underrepresented minorities in STEM.

Geeta J. Narlikar is an Indian–American biochemist who is Professor and the Lewis and Ruth Cozen Chair at the University of California, San Francisco. Her research considers epigenetic regulation and genome organisation. She was elected a Member of the National Academy of Sciences in 2021.

<span class="mw-page-title-main">Ellen Rothenberg (scientist)</span> American biologist

Ellen V. Rothenberg is an American biologist who is an Edward B. Lewis Professor of Biology at the California Institute of Technology. She investigates the molecular mechanisms that underpin lineage choice. She is an elected fellow of the American Association for the Advancement of Science, American Academy of Arts and Sciences and the National Academy of Sciences.

Hana El-Samad is a Lebanese-American scientist who is a founding Principal Investigator at Altos Labs and a Professor of Biochemistry and Biophysics at the University of California, San Francisco. Her work considers control theory and the function of complex biological systems. Her group has made contributions to systems biology, synthetic biology, and cell engineering.

Eran Meshorer is an Israeli scientist, professor of epigenetics and stem cells at the Alexander Silberman Institute of Life Sciences, and The Edmond and Lily Safra Center for Brain Sciences, the Hebrew University of Jerusalem. Meshorer is the Arthur Gutterman Chair for Stem Cell Research.

Minkui Luo is a biochemist and professor of biochemistry at Memorial Sloan Kettering Cancer Center. His research interests include chemical biology and the study of posttranslational modifications in epigenetic signaling, with an emphasis on protein methyltransferases.

Aindrila Mukhopadhyay is an American scientist who is the Division Deputy of the Biological Systems and Engineering Division at Lawrence Berkeley National Laboratory. Her research involves microbial engineering for the production of biofuels. She was nominated a Fellow of the American Association for the Advancement of Science in 2022.

References

  1. ↑ "Faculty | Coulter Department of Biomedical Engineering at Georgia Tech and Emory University". bme.gatech.edu. Retrieved 2020-08-16.
  2. ↑ "Karmella A. Haynes, PhD". winshipcancer.emory.edu. Retrieved 2020-08-16.
  3. ↑ "About". Karmella Haynes | Artist. 2015-04-05. Retrieved 2018-05-10.
  4. 1 2 3 4 "2017 General Purpose". www.ncbi.nlm.nih.gov. Retrieved 2018-05-10.
  5. 1 2 3 "The Cell Conductor". Grow by Ginkgo. 2020-06-23. Retrieved 2020-07-12.
  6. 1 2 3 4 "Karmella Haynes: Turning the Dials". The Scientist. Retrieved 2018-05-10.
  7. ↑ "MIT Summer Research Program – General (MSRP) | Office of Graduate Education" . Retrieved 2020-07-12.
  8. ↑ "Karmella Haynes: Synthetic Biologist, Artist, Advocate, and Ultimate Puzzle Solver". Benchling. 2019-02-12. Retrieved 2020-07-13.
  9. ↑ Haynes, Karmella A.; Caudy, Amy A.; Collins, Lynne; Elgin, Sarah C.R. (2006-11-21). "Element 1360 and RNAi Components Contribute to HP1-Dependent Silencing of a Pericentric Reporter". Current Biology. 16 (22): 2222–2227. Bibcode:2006CBio...16.2222H. doi:10.1016/j.cub.2006.09.035. ISSN   0960-9822. PMC   1712676 . PMID   17113386.
  10. 1 2 Daer, René M.; Cutts, Josh P.; Brafman, David A.; Haynes, Karmella A. (2017-03-17). "The Impact of Chromatin Dynamics on Cas9-Mediated Genome Editing in Human Cells". ACS Synthetic Biology. 6 (3): 428–438. doi:10.1021/acssynbio.5b00299. ISSN   2161-5063. PMC   5357160 . PMID   27783893.
  11. ↑ Nyer, David B.; Daer, Rene M.; Vargas, Daniel; Hom, Caroline; Haynes, Karmella A. (2017-01-09). "Regulation of cancer epigenomes with a histone-binding synthetic transcription factor". npj Genomic Medicine. 2. doi:10.1038/s41525-016-0002-3. ISSN   2056-7944. PMC   5600530 . PMID   28919981.
  12. 1 2 Haynes, Karmella A.; Silver, Pamela A. (2011-08-05). "Synthetic Reversal of Epigenetic Silencing". The Journal of Biological Chemistry. 286 (31): 27176–27182. doi: 10.1074/jbc.C111.229567 . ISSN   0021-9258. PMC   3149311 . PMID   21669865.
  13. ↑ "Time to Teach" (PDF). HHMI. Retrieved 2018-05-10.
  14. ↑ "Living computers solve complex math puzzle". NBC News. 2008-06-02. Retrieved 2018-05-10.
  15. ↑ "Environment". The Telegraph. 2016-03-30. ISSN   0307-1235. Archived from the original on 2016-04-01. Retrieved 2018-05-10.
  16. ↑ "Calculating Bacteria: Real Computer Bugs?". NPR.org. Retrieved 2018-05-10.
  17. 1 2 Haynes, Karmella A.; Broderick, Marian L.; Brown, Adam D.; Butner, Trevor L.; Dickson, James O.; Harden, W. Lance; Heard, Lane H.; Jessen, Eric L.; Malloy, Kelly J. (2008). "Engineering bacteria to solve the Burnt Pancake Problem". Journal of Biological Engineering. 2 (1): 8. doi: 10.1186/1754-1611-2-8 . ISSN   1754-1611. PMC   2427008 . PMID   18492232.
  18. ↑ "Davidson 2006 - 2006.igem.org". 2006.igem.org. Retrieved 2020-07-12.
  19. ↑ Haynes, Karmella A.; Ceroni, Francesca; Flicker, Daniel; Younger, Andrew; Silver, Pamela A. (2012). "A Sensitive Switch for Visualizing Natural Gene Silencing in Single Cells". ACS Synthetic Biology. 1 (3): 99–106. doi:10.1021/sb3000035. PMC   3331714 . PMID   22530199.
  20. ↑ "Engineers from Day One". Issuu. Retrieved 2018-05-10.
  21. ↑ "Karmella Haynes". asu.pure.elsevier.com. Archived from the original on 2018-05-11. Retrieved 2018-05-10.
  22. ↑ "Karmella Haynes-Farrell | EBRC". www.ebrc.org. Archived from the original on 2018-05-11. Retrieved 2018-05-10.
  23. ↑ "BME Lecture Series: Karmella Haynes, Arizona State University | The Henry Samueli School of Engineering at UC Irvine". engineering.uci.edu. Retrieved 2018-05-10.
  24. ↑ "314: Dr. Karmella Haynes: Expressing Her Creativity Making Epigenetic Machinery and Designing Biological Devices - People Behind the Science Podcast". www.peoplebehindthescience.com. 2015-10-12. Retrieved 2018-05-10.
  25. ↑ Karmella, Haynes. "Synthetic chromatin for cancer research". Grantome.
  26. ↑ "Team:Arizona State/Team - 2017.igem.org". 2017.igem.org. Retrieved 2018-05-10.
  27. ↑ "People". Haynes Lab | Emory. 2015-12-26. Retrieved 2020-07-13.
  28. ↑ "AfroBiotech Conference 2019". www.aiche.org. 2019-03-06. Retrieved 2020-07-13.
  29. ↑ "Synthetic Biology | CSHL". meetings.cshl.edu. Retrieved 2020-07-13.
  30. ↑ "Competition/Responsible Conduct - 2018.igem.org". 2018.igem.org. Retrieved 2020-07-13.
  31. ↑ "Competition/Rules of Conduct/Responsible Conduct - 2019.igem.org". 2019.igem.org. Retrieved 2020-07-13.
  32. ↑ "Career Profile: Synthetic Biologist Karmella Haynes". PBS LearningMedia. Retrieved 2018-05-10.
  33. ↑ "Combining art and science: Karmella Haynes interview". betterposters.blogspot.co.uk. 2011-09-22. Retrieved 2018-05-10.
  34. ↑ "Karmella Haynes - Artist". The Scientist. Retrieved 2018-05-10.
  35. ↑ "More art & science – hand painted poster at Synthetic Biology #synbio5 – by Karmella Haynes". Jonathan Eisen's Lab. 2011-06-16. Retrieved 2018-05-10.
  36. ↑ "Meet Our Scientists". www.buildingwithbiology.org. Retrieved 2018-05-10.
  37. ↑ "Karmella Haynes - Science Friday". Science Friday. Retrieved 2018-05-10.
  38. 1 2 "Karmella Haynes". SB7.0. Retrieved 2020-07-13.
  39. ↑ "Our Members | EBRC" . Retrieved 2020-07-13.
  40. ↑ "Karmella Haynes, PH.D. - Assistant Professor at Emory University". The Ella Project. June 2018. Retrieved 2020-07-13.
  41. ↑ "Karmella A. Haynes". www.aiche.org. 2017-07-19. Retrieved 2020-07-13.
  42. ↑ Sun, Fang-Lin; Haynes, Karmella; Simpson, Cory L.; Lee, Susan D.; Collins, Lynne; Wuller, Jo; Eissenberg, Joel C.; Elgin, S. C. R. (September 2004). "cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four". Molecular and Cellular Biology. 24 (18): 8210–8220. doi:10.1128/MCB.24.18.8210-8220.2004. ISSN   0270-7306. PMC   515050 . PMID   15340080.
  43. ↑ Moe-Behrens, Gerd H. G.; Davis, Rene; Haynes, Karmella A. (2013-01-25). "Preparing synthetic biology for the world". Frontiers in Microbiology. 4: 5. doi: 10.3389/fmicb.2013.00005 . ISSN   1664-302X. PMC   3554958 . PMID   23355834.
  44. ↑ Haynes, Karmella A.; Caudy, Amy A.; Collins, Lynne; Elgin, Sarah C.R. (2006-11-21). "Element 1360 and RNAi Components Contribute to HP1-Dependent Silencing of a Pericentric Reporter". Current Biology. 16 (22): 2222–2227. Bibcode:2006CBio...16.2222H. doi:10.1016/j.cub.2006.09.035. ISSN   0960-9822. PMC   1712676 . PMID   17113386.
  45. ↑ Haynes, Karmella A.; Silver, Pamela A. (2011-08-05). "Synthetic Reversal of Epigenetic Silencing". Journal of Biological Chemistry. 286 (31): 27176–27182. doi: 10.1074/jbc.C111.229567 . ISSN   0021-9258. PMC   3149311 . PMID   21669865. S2CID   11842108.
  46. ↑ Haynes, Karmella A.; Silver, Pamela A. (2009-11-30). "Eukaryotic systems broaden the scope of synthetic biology". Journal of Cell Biology. 187 (5): 589–596. doi:10.1083/jcb.200908138. ISSN   0021-9525. PMC   2806586 . PMID   19948487.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.