Sarah Elgin

Last updated
Sarah C.R. Elgin
Sarah elgin.jpg
Sarah C.R. Elgin
Alma mater Pomona College
California Institute of Technology
Known for heterochromatin, science education
Awards
  • Faculty Award, Council of Students of Arts and Sciences, WU, 1997
  • Fellows Award, Academy of Science of St. Louis, 2000
  • Bruce Alberts Award (with M. Campbell) for Excellence in Science Education, ASCB, 2006
  • Award for Exemplary Contributions to Education, ASBMB, 2007
  • Elizabeth W. Jones Award for Excellence in Education, GSA, 2009
  • Member, American Academy of Arts and Sciences, elected 2012
  • Doctor of Science, Honoris Causa, Pomona College, 2017
  • Member, National Academy of Sciences, elected 2018
  • Arthur Holly Compton Faculty Achievement Award, Washington University in St. Louis, 2018
Scientific career
Fields Biochemistry, Cell Biology, Genetics, Epigenetics
Institutions California Institute of Technology
Harvard University
Washington University in St. Louis
Doctoral advisor James Bonner
Other academic advisorsLeroy Hood
Doctoral students Lee M. Silver
Carl Wu
Thomas Dietz
Karmella Haynes

Sarah C.R. Elgin is an American biochemist and geneticist. She is the Viktor Hamburger Distinguished Professor Emerita of Arts and Sciences, and Professor Emerita of Biology at Washington University in St. Louis. She is noted for her work in epigenetics, gene regulation, and heterochromatin, and for her contributions to science education.

Contents

Early life and education

Sarah "Sally" Elgin was born in Washington, D.C. She grew up in Salem, Oregon. [1] In high school, Elgin became fascinated with chemisty and became a finalist in the national Westinghouse Science Talent Search in 1963. [2] She received her B.A. in chemistry from Pomona College in 1967. [3] [1] While at Pomona, she participated in a summer research program at the University of Leeds characterizing the egg stalk of the green lacewing fly Chrysopa vittata. [4] Elgin did her graduate work in the lab of James Bonner at the California Institute of Technology, isolating and characterizing nonhistone chromosomal proteins from rat livers and other sources. She received her Ph.D. in biochemistry in 1972. [1] Elgin stayed at California Institute of Technology for her postdoctoral research, working in the lab of Leroy Hood. She continued to isolate and characterize nonhistone chromosomal proteins but started using Drosophila as a model system, inspired by the ability to combine biochemistry, cytology, and genetics in flies.

Academic career and research

After her postdoc, Elgin joined the faculty in the Department of Biochemistry and Molecular Biology at Harvard University, [1] where her lab pioneered immunostaining of polytene chromosomes from Drosophila larval salivary glands [5] and nuclease digestion assays to determine organizational patterns of nucleosomes at active and inactive genes. [6] [7]

In 1981, Elgin joined the faculty in the Department of Biology at Washington University in St. Louis. Her lab identified and characterized Heterochromatin Protein 1 in Drosophila [8] (now known as Su(var)205 or HP1a) and demonstrated that it is essential for heterochromatin formation. [9] To probe chromatin environments, her lab developed a P element construct with a copy of the white gene driven by the hsp70 promoter. When this reporter gene is inserted into heterochromatic environments, the fly eyes display a variegating phenotype, whereas when the P element is inserted into euchromatin the fly eyes show a red phenotype; this phenomenon is known as Position-Effect Variegation. Use of this system enabled characterization of unique structural features of heterochromatin.

At Washington University, in the St. Louis area, and nationally, Elgin has been active in science education. She founded the Washington University Science Outreach program (now the Institute for K-12 School Partnership) in 1989 and has been active in science education in the University City school district. She also lobbied for the establishment of the Office of Undergraduate Research at Washington University and promoted the incorporation of research into undergraduate lab courses. In 2006, Elgin was named as the inaugural Viktor Hamburger Distinguished Professor of Arts and Sciences.

Examining Flies SarahElginFlies.jpg
Examining Flies

Genomics Education Partnership

In 2002, Elgin became an HHMI Professor with the goal to develop core curriculum to integrate primary research in genomics into a college lab course called "Research Explorations in Genomics." In June 2005, Elgin held a one-day hands-on introductory workshop at Washington University in St. Louis to show visiting faculty what her students were able to do in genome annotation. The 17 faculty who attended all signed on to a proposal to the Howard Hughes Medical Institute (HHMI) to establish the Genomics Education Partnership (GEP). The HHMI grant was funded, and GEP’s first cohort of members attended a full training workshop in June 2006. [10]

Starting from the laboratory course at Washington University, the GEP has engaged students in improving the sequence and gene annotation of different species of Drosophila fruit flies, initially focusing on the F Element, a small chromosome that is largely heterochromatic, but has 80 transcribed genes. [11] [12] The GEP has grown into a consortium of over 200 faculty members from colleges and universities, now led by Professor Laura Reed (University of Alabama). [13] GEP students participate in gene annotation projects with the goal of publishing results in primary research journals. GEP faculty also collaborate to publish data on learning experiences for students taking research-intensive classes based on the GEP approach. [11] [12] [14]

Awards and honors

Notes and references

  1. 1 2 3 4 5 6 "Sarah C. Elgin". National Academy of Sciences. Retrieved August 30, 2018.
  2. "Westinghouse Science Talent Search 1963".
  3. "Starr Named to Academy". Pomona College Magazine. Pomona College. 24 June 2020. Retrieved 29 August 2020.
  4. Roberts, S.C. (1966). "Brief description of the early stages of Chrysopa vittata (Neuroptera Chrysopidae)". Entomologist's Gazette. 17: 85–89.
  5. Silver, L M; Elgin, S C (February 1976). "A method for determination of the in situ distribution of chromosomal proteins". Proc Natl Acad Sci USA. 73 (2): 423–427. Bibcode:1976PNAS...73..423S. doi: 10.1073/pnas.73.2.423 . PMC   335921 . PMID   813226.
  6. Wu, C; Bingham, PM; Livak, KJ; Holmgren, R; Elgin, SCR (April 1979). "The chromatin structure of specific genes: I. Evidence for higher order domains of defined DNA sequence". Cell. 16 (4): 797–806. doi:10.1016/0092-8674(79)90095-3. PMID   455449. S2CID   10025372.
  7. Wu, C; Wong, YC; Elgin, SCR (April 1979). "The chromatin structure of specific genes: II. Disruption of chromatin structure during gene activity". Cell. 16 (4): 807–814. doi:10.1016/0092-8674(79)90096-5. PMID   455450. S2CID   25861704.
  8. James, TC; Elgin, SCR (November 1986). "Identification of a nonhistone chromosomal protein associated with heterochromatin in Drosophila melanogaster and its gene". Mol Cell Biol. 6 (11): 3862–3872. doi:10.1128/MCB.6.11.3862. PMC   367149 . PMID   3099166.
  9. Eissenberg, JC; James, TC; Foster-Hartnett, DM; Hartnett, T; Ngan, V; Elgin, SC (1990). "Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster". Proc Natl Acad Sci USA. 87 (24): 9923–9927. Bibcode:1990PNAS...87.9923E. doi: 10.1073/pnas.87.24.9923 . PMC   55286 . PMID   2124708.
  10. Lopatto, D.; Alvarez, C.; Barnard, D.; Chandrasekaran, C.; Chung, H.-M.; Du, C.; Eckdahl, T.; Goodman, A. L.; Hauser, C.; Jones, C. J.; Kopp, O. R. (2008-10-31). "Undergraduate research. Genomics Education Partnership". Science. 322 (5902): 684–685. doi:10.1126/science.1165351. ISSN   1095-9203. PMC   2953277 . PMID   18974335.
  11. 1 2 Chris Shaffer, Consuelo Alvarez, Cheryl Bailey, Daron Barnard, Satish Bhalla, Chitra Chandrasekaran, Vidya Chandrasekaran, Hui-Min Chung, Doug Dorer, Chunguang Du, Todd Eckdahl, Jeff Poet, Donald Frohlich, Anya Goodman, Yuying Gosser, Charles Hauser, Laura Hoopes, Diana Johnson, Chris Jones, Marian Kaehler, Nighat Kokan, Olga Kopp, Gary Kuleck, Gerry McNeil, Robert Moss, Jennifer Myka, Alexis Nagengast, Robert Morris, Paul Overvoorde, Libby Shoop, Susan Parrish, Kelly Reed, E. Gloria Regisford, Dennis Revie, Anne Rosenwald, Ken Saville, Stephanie Schroeder, Mary Shaw, Christopher Smith, Mary Smith, Eric Spana, Mary Spratt, Joyce Stamm, Jeff Thompson, Matthew Wawersik, Barbara Wilson, Jim Youngblom, Wilson Leung, David Lopatto, Sarah C R Elgin.  The Genomics Education Partnership: Successful Integration of Research into Laboratory Classes at a Diverse Group of Undergraduate Institutions, Cell Biology Ed-Life Sci Ed9:35-40  (Spring, 2010).
  12. 1 2 Elgin, Sarah C. R.; Hauser, Charles; Holzen, Teresa M.; Jones, Christopher; Kleinschmit, Adam; Leatherman, Judith; Genomics Education Partnership (December 2016). "The GEP: Crowd-Sourcing Big Data Analysis with Undergraduates". Trends in Genetics. 33 (2): 81–85. doi:10.1016/j.tig.2016.11.004. ISSN   0168-9525. PMID   27939750.
  13. "The Genomics Education Partnership".
  14. Lopatto, David; Rosenwald, Anne G.; DiAngelo, Justin R.; Hark, Amy T.; Skerritt, Matthew; Wawersik, Matthew; Allen, Anna K.; Alvarez, Consuelo; Anderson, Sara; Arrigo, Cindy; Arsham, Andrew (2020). "Facilitating Growth through Frustration: Using Genomics Research in a Course-Based Undergraduate Research Experience". Journal of Microbiology & Biology Education. 21 (1): 40. doi:10.1128/jmbe.v21i1.2005. ISSN   1935-7877. PMC   7048401 . PMID   32148609.
  15. "Bruce Alberts Award". American Society for Cell Biology. Retrieved August 30, 2018.
  16. "Award for Excellence in Education". American Society for Biochemistry and Molecular Biology. Retrieved August 30, 2018.
  17. "Elizabeth W. Jones Award". Genetics Society of America. Retrieved August 30, 2018.
  18. "Members by Subject and Year of Election" (PDF). American Academy of Arts and Sciences. Retrieved August 30, 2018.