Kay Brummond

Last updated
Kay Michille Brummond
Alma mater University of Nebraska-Lincoln
Pennsylvania State University
Scientific career
Institutions University of Rochester
West Virginia University
University of Pittsburgh
Thesis Synthetic approach to the calicheamicin/esperamicin bicyclo(7.3.1)tridecenediyne ring core and sulfones in organic synthesis.  (1991)
Website Brummond Lab

Kay Michille Brummond is an American synthetic chemist who is Professor of Chemistry and Associate Dean of Faculty at the University of Pittsburgh. Her interests consider cycloaddition reactions that can realise molecules and natural products for organic photovoltaics and targeted covalent inhibitors. She was elected a Fellow of the American Chemical Society (ACS) in 2010, a Fellow of the AAAS in 2021, and awarded the ACS National Award for Encouraging Women into Careers in the Chemical Sciences in 2021.

Contents

Early life and education

Brummond grew up in the town of Herman in eastern Nebraska. [1] She grew up on a corn and soybeans farm, and was the first member of her family to attend college. She attended the Tekamah-Herman High School and earned her undergraduate degree in secondary education (B.S.) at the University of Nebraska–Lincoln. [1] [2] She moved to Pennsylvania State University for her doctoral research, where she focused on organic synthesis with Raymond L. Funk. [3] In 1991, she joined the University of Rochester, where she spent two years as a postdoctoral researcher with Robert K. Boeckman, Jr. [1]

Research and career

In 1993, Brummond joined the faculty at West Virginia University, where she was promoted to associate professor. She moved to the University of Pittsburgh in 2001, where she was promoted to professor in 2006 and elected department chair in 2014. [1] Brummond served as the Associate Dean of Faculty for the Dietrich School of Arts and Sciences at the University of Pittsburgh (2017–2023).

Brummond studies the Pauson–Khand reaction, targeted covalent inhibitors, [4] transition-metal catalyzed cyclocarbonylation, and dearomative cycloaddition reactions. [2] She works on the design, synthesis, and characterization of guaianolide analog covalent inhibitors with muted reactivity to thiols. In particular, she is interested in identifying the structure–activity relationships of these analogs. To assemble the 5,7,5-ring system, Brummond uses an allenic Pauson–Khand reactions and other cyclization process. To regulate the thiol reactivity and increase affinity for the kinase and protease targets, Brummond modifies the covalent reactive groups.

She has designed novel transition metal catalysts, including Rh(I). She has shown that stereoconvergent allenic Pauson–Khand reactions catalysed by Rh(I) can result in highly enantioselective 5,7-ring systems, which enable the enantioselective synthesis of compounds such as thapsigargin. [4] Her approach includes collaborations with computational chemists for the rational design of transition metal catalysts and ligands through analysis of transition-state structures and energies to achieve stereoselective reaction products.

Academic service

Brummond has advocated for women and underrepresented groups in science. [5] She has worked with both her home institutions and the American Chemical Society to improve gender balance, and recognized for this work as the Diversity Catalyst Lecturer by the Open Chemistry Collaborative in Diversity Equity (OXIDE) partnership mechanism in 2014. She established the University of Pittsburgh Summer Undergraduate Research Fellowship (SURF) program, which offers research placements to undergraduate students. [6] She launched various outreach programs to introduce young girls to scientific careers. Brummond has created a list of actions that people can take to become an ally to women working in chemistry, namely; [1]

  1. Inviting a woman chemist to give a seminar;
  2. Engaging with women’s research;
  3. Developing an inclusivity and/or diversity statement together with your research group;
  4. Nominating a woman for an award;
  5. Educating yourself on gender disparities, and barriers, and know the data;
  6. Celebrating the chemistry achievements of women;
  7. Working to prepare the next generation of women chemists;
  8. Mitigating unconscious biases through your actions; and
  9. Working to fix the institution not the individual.

Symposiums and Conferences Organized

Brummond has been active in organizing or co-organizing several national chemistry conferences including:

Awards and honors

Selected publications

For comprehensive listing of publications, see: https://scholar.google.com/citations?user=6iI4MkEAAAAJ&hl=en

Related Research Articles

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References

  1. 1 2 3 4 5 "An Interview with Kay Brummond, Recipient of the 2021 ACS Award for Encouraging Women into the Chemical Sciences". acswcc.org. 2 June 2021. Retrieved 2021-08-24.
  2. 1 2 3 "Kay Brummond | Kenneth P. Dietrich School of Arts & Sciences | University of Pittsburgh". www.as.pitt.edu. Retrieved 2021-08-24.
  3. ↑ Brummond, Kay Michille (1991). Synthetic approach to the calicheamicin/esperamicin bicyclo[7.3.1]tridencenediyne ring core and sulfones in organic synthesis (Thesis). OCLC   299217616.
  4. 1 2 "Research – Brummond Research Group" . Retrieved 2021-08-24.
  5. ↑ "C&E News Article - Diversity". cen.acs.org. Retrieved 2021-08-24.
  6. 1 2 "Chancellor's Distinguished Public Service Award Winners | Office of the Provost | University of Pittsburgh". www.provost.pitt.edu. Retrieved 2021-08-24.
  7. 1 2 "Organic Reactions and Processes - Gordon Research Conferences". www.grc.org. Retrieved 2021-10-17.
  8. ↑ "Past Meetings | TSRC". www.telluridescience.org. Retrieved 2021-10-17.
  9. 1 2 "- NOS History - ACS Division of Organic Chemistry" . Retrieved 2021-10-17.
  10. ↑ "Akron Section Award". www.akronacs.org. Archived from the original on 2013-08-02. Retrieved 2021-08-24.
  11. ↑ "Carnegie Science Awards". Carnegie Science Center. Retrieved 2021-09-25.
  12. ↑ "ACS Fellows". ACS Fellows Program. Retrieved October 5, 2021.
  13. ↑ "Pittsburgh Award". Pittsburgh ACS. Retrieved 2021-09-25.
  14. ↑ "Diversity Catalyst Lecturer | OXIDE". oxide.jhu.edu. Retrieved 2021-08-24.
  15. ↑ "PACWC's Spotlight on Women Leaders - Faculty | Office of the Provost | University of Pittsburgh". www.provost.pitt.edu. Retrieved 2021-08-24.
  16. ↑ "Prof. Kay Brummond is featured on PACWC's Spotlight on Women Leaders | Department of Chemistry | University of Pittsburgh". www.chem.pitt.edu. Retrieved 2021-08-24.
  17. ↑ "ACS National Award Winners 2021". cen.acs.org. Retrieved 2021-08-24.
  18. ↑ "Congratulations to Kay Brummond – ACS National 2021 Award for Encouraging Women into Careers in the Chemical Sciences". Pittsburgh ACS. 2020-10-21. Retrieved 2021-08-24.
  19. ↑ "Prof. Kay Brummond has received the ACS Award for Encouraging Women into Careers in Chemical Science. | Department of Chemistry | University of Pittsburgh". www.chem.pitt.edu. Retrieved 2021-08-24.
  20. ↑ "2021 AAAS Fellows". 2021 AAAS Fellows. 2022-04-07.
  21. ↑ "Organic Syntheses Board of Directors". Organic Syntheses, Board of Directors. 2022-04-07.
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