Kelch-like protein 1

KLHL1
Identifiers
Aliases	KLHL1 , MRP2, kelch like family member 1
External IDs	OMIM: 605332; MGI: 2136335; HomoloGene: 56903; GeneCards: KLHL1; OMA:KLHL1 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q21.33 Start 69,700,594 bp [1] End 70,108,493 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 E2.1 Start 96,340,172 bp [2] End 96,756,538 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pars reticulata pars compacta testicle superior vestibular nucleus ventral tegmental area pons hypothalamus islet of Langerhans ganglionic eminence prefrontal cortex Top expressed in ventral tegmental area substantia nigra lumbar subsegment of spinal cord lateral hypothalamus habenula ventromedial nucleus mammillary body supraoptic nucleus central gray substance of midbrain medial vestibular nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function ubiquitin-protein transferase activity actin binding Cellular component Cul3-RING ubiquitin ligase complex cytoskeleton dendrite soma cytoplasm Biological process cerebellar Purkinje cell layer development actin cytoskeleton organization locomotory behavior adult walking behavior dendrite development protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57626 93688 Ensembl ENSG00000150361 ENSMUSG00000022076 UniProt Q9NR64 Q9JI74 RefSeq (mRNA) NM_020866 NM_001286725 NM_053105 RefSeq (protein) NP_001273654 NP_065917 NP_444335 Location (UCSC) Chr 13: 69.7 – 70.11 Mb Chr 14: 96.34 – 96.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kelch-like protein 1 is a protein that in humans is encoded by the KLHL1 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000150361 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022076 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nemes JP, Benzow KA, Moseley ML, Ranum LP, Koob MD (Sep 2000). "The SCA8 transcript is an antisense RNA to a brain-specific transcript encoding a novel actin-binding protein (KLHL1)". Hum Mol Genet. 9 (10): 1543–51. doi: 10.1093/hmg/9.10.1543 . PMID   10888605.
6. "Entrez Gene: KLHL1 kelch-like 1 (Drosophila)".

Further reading

• Aromolaran KA, Benzow KA, Koob MD, Piedras-Rentería ES (2007). "The Kelch-like protein 1 modulates P/Q-type calcium current density". Neuroscience. 145 (3): 841–50. doi:10.1016/j.neuroscience.2006.12.046. PMID   17289272. S2CID   20055866.
• Seng S, Avraham HK, Jiang S, et al. (2007). "KLHL1/MRP2 mediates neurite outgrowth in a glycogen synthase kinase 3beta-dependent manner". Mol. Cell. Biol. 26 (22): 8371–84. doi:10.1128/MCB.02167-05. PMC   1636797 . PMID   16982692.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID   15761153. S2CID   39457788.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC   2665288 . PMID   15057823.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi: 10.1093/dnares/7.2.143 . PMID   10819331.