Kelch-like protein 2

KLHL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XN4, 4CHB
Identifiers
Aliases	KLHL2 , ABP-KELCH, MAV, MAYVEN, kelch like family member 2
External IDs	OMIM: 605774 MGI: 1924363 HomoloGene: 21416 GeneCards: KLHL2
Gene location (Human)
Chr.	Chromosome 4 (human)
End	165,323,156 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	65,302,669 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; Region I of hippocampus proper; ; postcentral gyrus; ; optic nerve; ; external globus pallidus; ; superior frontal gyrus; ; middle temporal gyrus; ; Brodmann area 46; ; orbitofrontal cortex; ; internal globus pallidus;
	Top expressed in
	olfactory tubercle; ; nucleus accumbens; ; dentate gyrus; ; globus pallidus; ; Region I of hippocampus proper; ; primary motor cortex; ; hippocampus proper; ; piriform cortex; ; cumulus cell; ; subiculum;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin-protein transferase activity ; protein binding ; actin binding ; identical protein binding ;
Cellular component	ruffle ; cell projection ; actin cytoskeleton ; lamellipodium ; cytoskeleton ; cytoplasm ; Cul3-RING ubiquitin ligase complex ; cytosol ;
Biological process	protein ubiquitination ; post-translational protein modification ;
	Sources:Amigo / QuickGO
Orthologs
	11275
	77113
	ENSG00000109466
	ENSMUSG00000031605
	O95198
	Q8JZP3
	NM_001161521 ; NM_001161522 ; NM_007246 ; NM_001331023 ; NM_001331024
	NM_178633
	NP_001154993 ; NP_001154994 ; NP_001317952 ; NP_001317953 ; NP_009177
	NP_848748
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 03, 2023

Kelch-like family member 2 is a protein that in humans is encoded by the KLHL2 gene.^[5]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000109466 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031605 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Kelch-like family member 2".

Tseng LA, Bixby JL (Aug 2011). "Interaction of an intracellular pentraxin with a BTB-Kelch protein is associated with ubiquitylation, aggregation and neuronal apoptosis". Molecular and Cellular Neurosciences. 47 (4): 254–64. doi:10.1016/j.mcn.2011.04.005. PMC 3137755 . PMID 21549840.
Korutla L, Wang P, Jackson TG, Mackler SA (2009). "NAC1, a POZ/BTB protein that functions as a corepressor". Neurochemistry International. 54 (3–4): 245–52. doi:10.1016/j.neuint.2008.12.008. PMID 19121354. S2CID 23462562.
Williams SK, Spence HJ, Rodgers RR, Ozanne BW, Fitzgerald U, Barnett SC (Sep 2005). "Role of Mayven, a kelch-related protein in oligodendrocyte process formation". Journal of Neuroscience Research. 81 (5): 622–31. doi:10.1002/jnr.20588. PMID 16035103. S2CID 31895360.
Dhanoa BS, Cogliati T, Satish AG, Bruford EA, Friedman JS (2013). "Update on the Kelch-like (KLHL) gene family". Human Genomics. 7 (1): 13. doi: 10.1186/1479-7364-7-13 . PMC 3658946 . PMID 23676014.
Mai A, Jung SK, Yonehara S (Oct 2004). "hDKIR, a human homologue of the Drosophila kelch protein, involved in a ring-like structure". Experimental Cell Research. 300 (1): 72–83. doi:10.1016/j.yexcr.2004.06.023. PMID 15383316.
Schumacher FR, Sorrell FJ, Alessi DR, Bullock AN, Kurz T (Jun 2014). "Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation". The Biochemical Journal. 460 (2): 237–46. doi:10.1042/BJ20140153. PMC 4019986 . PMID 24641320.
Soltysik-Espanola M, Rogers RA, Jiang S, Kim TA, Gaedigk R, White RA, Avraham H, Avraham S (Jul 1999). "Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain". Molecular Biology of the Cell. 10 (7): 2361–75. doi:10.1091/mbc.10.7.2361. PMC 25454 . PMID 10397770.
Bu X, Avraham HK, Li X, Lim B, Jiang S, Fu Y, Pestell RG, Avraham S (Mar 2005). "Mayven induces c-Jun expression and cyclin D1 activation in breast cancer cells". Oncogene. 24 (14): 2398–409. doi: 10.1038/sj.onc.1208466 . PMID 15735724.
Takahashi D, Mori T, Wakabayashi M, Mori Y, Susa K, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S (Aug 2013). "KLHL2 interacts with and ubiquitinates WNK kinases". Biochemical and Biophysical Research Communications. 437 (3): 457–62. doi:10.1016/j.bbrc.2013.06.104. PMID 23838290.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000109466 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031605 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Kelch-like family member 2".

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[5]

Kelch-like protein 2

Related Research Articles

References

Further reading