Kelch-like protein 20

KLHL20
Identifiers
Aliases	KLHL20 , KHLHX, KLEIP, KLHLX, kelch like family member 20
External IDs	OMIM: 617679 MGI: 2444855 HomoloGene: 8699 GeneCards: KLHL20
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q25.1 Start 173,714,941 bp [1] End 173,786,692 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 H2.1 Start 160,915,945 bp [2] End 160,959,081 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Achilles tendon sperm nipple popliteal artery gallbladder right coronary artery stromal cell of endometrium smooth muscle tissue urethra Top expressed in facial motor nucleus cumulus cell anterior horn of spinal cord blood trigeminal ganglion thymus ureter spermatocyte interventricular septum triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin-protein transferase activity protein binding interferon-gamma binding actin binding Cellular component nucleus cell projection actin cytoskeleton Cul3-RING ubiquitin ligase complex perinuclear region of cytoplasm dendrite trans-Golgi network axon cytoplasm Golgi apparatus PML body cytosol Biological process Golgi to endosome transport protein K33-linked ubiquitination cytoskeleton organization protein transport proteasome-mediated ubiquitin-dependent protein catabolic process response to interferon-alpha protein ubiquitination negative regulation of apoptotic process post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27252 226541 Ensembl ENSG00000076321 ENSMUSG00000026705 UniProt Q9Y2M5 Q8VCK5 RefSeq (mRNA) NM_014458 NM_001039482 NM_144876 RefSeq (protein) NP_055273 NP_001034571 Location (UCSC) Chr 1: 173.71 – 173.79 Mb Chr 1: 160.92 – 160.96 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kelch-like protein 20 is a protein that in humans is encoded by the KLHL20 gene. ^{[5] [6]}

The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 44-56 amino acid repeat motif. The kelch motif appears in many different polypeptide contexts and contains multiple potential protein-protein contact sites. Members of this family are present both throughout the cell and extracellularly, with diverse activities. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000076321 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026705 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hara T, Ishida H, Raziuddin R, Dorkhom S, Kamijo K, Miki T (Mar 2004). "Novel kelch-like protein, KLEIP, is involved in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells". Mol Biol Cell. 15 (3): 1172–84. doi:10.1091/mbc.E03-07-0531. PMC   363103 . PMID   14668487.
6. "Entrez Gene: KLHL20 kelch-like 20 (Drosophila)".

Further reading

• Adams J, Kelso R, Cooley L (2000). "The kelch repeat superfamily of proteins: propellers of cell function". Trends Cell Biol. 10 (1): 17–24. doi:10.1016/S0962-8924(99)01673-6. PMID   10603472.
• Nemes JP, Benzow KA, Moseley ML, et al. (2000). "The SCA8 transcript is an antisense RNA to a brain-specific transcript encoding a novel actin-binding protein (KLHL1)". Hum. Mol. Genet. 9 (10): 1543–51. doi: 10.1093/hmg/9.10.1543 . PMID   10888605.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Shin BK, Wang H, Yim AM, et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. doi: 10.1074/jbc.M210455200 . PMID   12493773.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Nacak TG, Alajati A, Leptien K, et al. (2007). "The BTB-Kelch protein KLEIP controls endothelial migration and sprouting angiogenesis". Circ. Res. 100 (8): 1155–63. doi: 10.1161/01.RES.0000265844.56493.ac . PMID   17395875.