Kevan Shokat

Last updated
Kevan Michael Shokat
Born (1964-08-26) August 26, 1964 (age 60)
Alma mater Reed College
University of California, Berkeley
Known for Kinase signaling
Scientific career
Fields Chemical biology
Institutions Princeton University
University of California, San Francisco
Doctoral advisor Peter G. Schultz
Other academic advisors Christopher Goodnow

Kevan Michael Shokat (born August 26, 1964) [1] is an American chemical biologist. He is a Professor and chair in the Department of Cellular and Molecular Pharmacology at University of California, San Francisco, a professor in the Department of Chemistry at University of California, Berkeley, and an Investigator with the Howard Hughes Medical Institute.

Contents

Biography

Shokat received his B.A, in chemistry from Reed College in 1986, completing his thesis, "Synthesis of a precursor of PRCPCP, a non-hydrolyzable analog of phosphoribosylpyrophosphate (PRPP)," with Ron McClard, and his Ph.D. from University of California, Berkeley in 1991, under Peter G. Schultz.

Research

Shokat is one of the leading figures in the field of chemical genetics. [2] He uses methods of bioorganic chemistry to elucidate signal transduction pathways at the single cell and whole organism levels, and is particularly interested in protein kinases, and developing methods to elucidate the particular targets of each kinase, such as the Bump and hole method.

In 2013 Shokat published the first covalent inhibitors of KRAS G12C using a tethering screen. [3] Following this strategy many pharma companies have developed KRAS programs leading to phase I/II clinical trials in this space, a landmark for what was once thought to be an undruggable oncogene.

Honors and awards

Related Research Articles

The National Academy of Sciences Award in Chemical Sciences is awarded for innovative research in the chemical sciences that in the broadest sense contributes to a better understanding of the natural sciences and to the benefit of humanity.

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References

  1. "Oral history interview with Kevan M. Shokat". Science History Institute Digital Collections. Retrieved 2022-08-21.
  2. "Kevan Shokat at the Michael j. Fox foundation" . Retrieved 1 February 2017.
  3. Ostrem, Jonathan M.; Peters, Ulf; Sos, Martin L.; Wells, James A.; Shokat, Kevan M. (November 2013). "K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions". Nature. 503 (7477): 548–551. Bibcode:2013Natur.503..548O. doi:10.1038/nature12796. PMC   4274051 . PMID   24256730.
  4. "Kevan M. Shokat, Ph.D."
  5. "The Protein Society : Protein Society Awards". proteinsociety.org. 2019-12-03. Archived 2019-12-03 at the Wayback Machine
  6. Eli Lilly Award in Biological Chemistry Archived 2020-10-09 at the Wayback Machine , Prizewinners 1935 - 2017, retrieved 1/26/2017
  7. Kevan M. Shokat, at National Academy of Sciences (nasonline.org), retrieved 1/26/2017
  8. Book of Members 1780–present, Members of the American Academy of Arts & Sciences, 1780-2016, retrieved 1/26/2017
  9. "Ronald Breslow Award for Achievement in Biomimetic Chemistry".
  10. "Kraft Prize Symposium".
  11. "Frank H. Westheimer Prize".
  12. "Priming Cancer Cells for Detection by the Immune System". July 2019.
  13. "Past Recipients".
  14. "Kevan Shokat Ph.D. To be Awarded the First SWCRF Breakthrough Science Award".
  15. "AACR Announces Recipients of its 2022 Scientific Achievement Awards and Lectureships".
  16. "NAS Award for Scientific Discovery".
  17. "Dr. Kevan Shokat '86 Receives Vollum Award for Cancer Research". 17 February 2023.
  18. "Sjöberg Laureate brings new hope to people with lung cancer".