L3MBTL2

L3MBTL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2W0T, 3CEY, 3F70
Identifiers
Aliases	L3MBTL2 , H-l(3)mbt-l, L3MBT, L3MBTL2 polycomb repressive complex 1 subunit, polycomb repressive complex 1 subunit, L3MBTL histone methyl-lysine binding protein 2
External IDs	OMIM: 611865; MGI: 2443584; HomoloGene: 12882; GeneCards: L3MBTL2; OMA:L3MBTL2 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.2 Start 41,205,282 bp [1] End 41,231,271 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 E1 Start 81,548,090 bp [2] End 81,572,516 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell tibialis anterior muscle parotid gland nasal epithelium skin of arm mucosa of ileum cerebellar vermis external globus pallidus gingival epithelium right frontal lobe Top expressed in spermatocyte epiblast otolith organ hand utricle cumulus cell superior cervical ganglion tail of embryo primary oocyte seminiferous tubule More reference expression data BioGPS n/a
Gene ontology Molecular function histone binding zinc ion binding protein binding metal ion binding methylated histone binding Cellular component nucleus nucleoplasm Biological process regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of G0 to G1 transition chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83746 214669 Ensembl ENSG00000100395 ENSMUSG00000022394 UniProt Q969R5 P59178 RefSeq (mRNA) NM_001003689 NM_031488 NM_001289711 NM_001289712 NM_145993 RefSeq (protein) NP_113676 NP_001276640 NP_001276641 NP_666105 Location (UCSC) Chr 22: 41.21 – 41.23 Mb Chr 15: 81.55 – 81.57 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Lethal(3)malignant brain tumor-like 2 protein is a protein that in humans is encoded by the L3MBTL2 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000100395 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022394 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wismar J (Oct 2001). "Molecular characterization of h-l(3)mbt-like: a new member of the human mbt family". FEBS Letters. 507 (1): 119–21. doi: 10.1016/S0014-5793(01)02959-3 . PMID   11682070.
6. "Entrez Gene: L3MBTL2 l(3)mbt-like 2 (Drosophila)".

Further reading

• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Ogawa H, Ishiguro K, Gaubatz S, Livingston DM, Nakatani Y (May 2002). "A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells". Science. 296 (5570): 1132–6. Bibcode:2002Sci...296.1132O. doi:10.1126/science.1069861. PMID   12004135. S2CID   34863978.
• Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC   545604 . PMID   15461802.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.