LANCL1

LANCL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3E6U, 3E73
Identifiers
Aliases	LANCL1 , GPR69A, p40, LanC like 1
External IDs	OMIM: 604155 MGI: 1336997 HomoloGene: 4417 GeneCards: LANCL1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	210,477,652 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	67,078,031 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; corpus callosum; ; inferior ganglion of vagus nerve; ; subthalamic nucleus; ; inferior olivary nucleus; ; Brodmann area 46; ; postcentral gyrus; ; external globus pallidus; ; middle temporal gyrus; ; Brodmann area 23;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; corneal stroma; ; facial motor nucleus; ; anterior horn of spinal cord; ; barrel cortex; ; cingulate gyrus; ; olfactory tubercle; ; amygdala;
	More reference expression data
	n/a
Gene ontology
Molecular function	SH3 domain binding ; low-density lipoprotein particle receptor binding ; zinc ion binding ; protein binding ; G protein-coupled receptor activity ; metal ion binding ; glutathione binding ; catalytic activity ; glutathione transferase activity ; transferase activity ;
Cellular component	cytoplasm ; integral component of plasma membrane ; membrane ; plasma membrane ;
Biological process	G protein-coupled receptor signaling pathway ; regulation of neuron apoptotic process ; regulation of oxidative stress-induced neuron death ;
	Sources:Amigo / QuickGO
Orthologs
	10314
	14768
	ENSG00000115365
	ENSMUSG00000026000
	O43813
	O89112
	NM_001136574 ; NM_001136575 ; NM_006055
	NM_001190984 ; NM_001190985 ; NM_021295
	NP_001130046 ; NP_001130047 ; NP_006046
	NP_001177913 ; NP_001177914 ; NP_067270
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

LanC like 1 is a protein that in humans is encoded by the LANCL1 gene. ^[5]

Function

This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115365 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026000 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: LanC like 1" . Retrieved 2016-04-20.

LANCL1

Contents

Function

Related Research Articles

References

Further reading