LAS1L

LAS1L
Identifiers
Aliases	LAS1L , Las1-like, dJ475B7.2, LAS1-like, ribosome biogenesis factor, LAS1 like, ribosome biogenesis factor, WTS, Las1, LAS1 like ribosome biogenesis factor, MRXSWTS
External IDs	OMIM: 300964 MGI: 1923380 HomoloGene: 32746 GeneCards: LAS1L
Gene location (Human)
Chr.	X chromosome (human)
End	65,534,810 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	95,000,568 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; putamen; ; cingulate gyrus; ; amygdala; ; nucleus accumbens; ; Brodmann area 9; ; caudate nucleus; ; right uterine tube; ; endothelial cell; ; nipple;
	Top expressed in
	primitive streak; ; supraoptic nucleus; ; yolk sac; ; superior frontal gyrus; ; vas deferens; ; cerebellar cortex; ; abdominal wall; ; mirror; ; ankle; ; neural tube;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA binding ; endonuclease activity ;
Cellular component	MLL1 complex ; nucleolus ; membrane ; nucleus ; nucleoplasm ; cytoplasm ; preribosome, large subunit precursor ; Las1 complex ;
Biological process	rRNA processing ; maturation of 5.8S rRNA ; maturation of LSU-rRNA ; endonucleolytic cleavage involved in rRNA processing ; chromatin organization ; nucleic acid phosphodiester bond hydrolysis ;
	Sources:Amigo / QuickGO
Orthologs
	81887
	76130
	ENSG00000001497
	ENSMUSG00000057421
	Q9Y4W2
	A2BE28
NM_001170649 ; NM_001170650 ; NM_031206 ; NM_001375328 ; NM_001375329 ;
	NM_001375330 ; NM_001375331 ; NM_001375332 ; NM_001375333 ; NM_001375334 ; NM_001375335 ; NM_001375336 ; NM_001375337
	NM_152822 ; NM_001374717
NP_001164120 ; NP_001164121 ; NP_112483 ; NP_001362257 ; NP_001362258 ;
	NP_001362259 ; NP_001362260 ; NP_001362261 ; NP_001362262 ; NP_001362263 ; NP_001362264 ; NP_001362265 ; NP_001362266
	NP_690035 ; NP_001361646
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 13, 2022

LAS1-like protein is a protein that in humans is encoded by the LAS1L gene.^[5]^[6]

Related Research Articles

Protein N-terminal glutamine amidohydrolase is an enzyme that in humans is encoded by the WDYHV1 gene.

Zinc finger protein 655 is a protein that in humans is encoded by the ZNF655 gene.

Tubulin gamma-2 chain is a protein that in humans is encoded by the TUBG2 gene.

Nuclear receptor-binding factor 2 is a protein that in humans is encoded by the NRBF2 gene.

Zinc finger protein 219 is a protein that in humans is encoded by the ZNF219 gene.

Protein GPR89 is a protein that in humans is encoded by the GPR89B gene.

Thioredoxin-related transmembrane protein 4 also known as thioredoxin domain-containing protein 13 is a protein that in humans is encoded by the TMX4 gene.

KIAA1166 is a human gene.

Vacuolar protein sorting-associated protein 52 homolog is a protein that in humans is encoded by the VPS52 gene.

Spermatogenesis-defective protein 39 homolog is a protein that in humans is encoded by the VIPAS39 gene. This protein is involved in the sorting of lysosomal proteins. Mutations in this gene are associated with ARCS2. Alternative splicing results in multiple transcript variants.

EF-hand calcium-binding domain-containing protein 6 is a protein that in humans is encoded by the EFCAB6 gene.

Coiled-coil domain-containing protein 28B is a protein that in humans is encoded by the CCDC28B gene.

Protein POF1B is a protein that in humans is encoded by the POF1B gene.

Transmembrane 9 superfamily member 2 is a protein that in humans is encoded by the TM9SF2 gene.

RWD domain-containing protein 2B is a protein that in humans is encoded by the RWDD2B gene.

DnaJ homolog subfamily C member 28 is a protein that in humans is encoded by the DNAJC28 gene. It's a member of chaperone DnaJ family. The family is also known as Hsp40.

Zinc finger protein 8 is a protein that in humans is encoded by the ZNF8 gene.

Epidermal growth factor receptor kinase substrate 8-like protein 3 is an enzyme that in humans is encoded by the EPS8L3 gene.

Centrosomal protein of 70 kDa is a protein that in humans is encoded by the CEP70 gene. The protein interacts with γ-tubulin through its coiled coil domains to localize at the centrosome. CEP70 is involved in organizing microtubules in interphase cells and is required for proper organization and orientation of the mitotic spindle.

Coiled-coil domain-containing protein 70 is a protein that in humans is encoded by the CCDC70 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000001497 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057421 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
↑ "Entrez Gene: LAS1L LAS1-like (S. cerevisiae)".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617 . PMID 12429849.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286 . PMID 15772651.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000001497 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057421 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12477932-5] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.

[entrez-6] "Entrez Gene: LAS1L LAS1-like (S. cerevisiae)".

[1]

[2]

[3]

[4]

[5]

[6]

LAS1L

Related Research Articles

References

Further reading