LASP1

LASP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3I35
Identifiers
Aliases	LASP1 , MLN50, LIM and SH3 protein 1, LASP-1
External IDs	OMIM: 602920 MGI: 109656 HomoloGene: 4480 GeneCards: LASP1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	38,921,770 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	97,729,590 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; jejunal mucosa; ; lactiferous duct; ; duodenum; ; stromal cell of endometrium; ; superficial temporal artery; ; spongy bone; ; thymus; ; pylorus; ; blood;
	Top expressed in
	retinal pigment epithelium; ; conjunctival fornix; ; external carotid artery; ; ciliary body; ; internal carotid artery; ; epithelium of stomach; ; otic placode; ; saccule; ; sexually immature organism; ; iris;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ion transmembrane transporter activity ; actin filament binding ; actin binding ; protein binding ; metal ion binding ; cadherin binding ;
Cellular component	cell cortex ; extracellular exosome ; cytoskeleton ; focal adhesion ; cortical actin cytoskeleton ; cytoplasm ;
Biological process	ion transmembrane transport ; ion transport ; positive regulation of signal transduction ; transport ;
	Sources:Amigo / QuickGO
Orthologs
	3927
	16796
	ENSG00000002834
	ENSMUSG00000038366
	Q14847
	Q61792
	NM_001271608 ; NM_006148
	NM_010688
	NP_001258537 ; NP_006139
	NP_034818
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 12, 2023

LIM and SH3 domain protein 1 is a protein that in humans is encoded by the LASP1 gene.^[5]^[6]

Interactions

LASP1 has been shown to interact with Zyxin.^[7]

Related Research Articles

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<span class="mw-page-title-main">LIM domain</span> InterPro Domain

LIM domains are protein structural domains, composed of two contiguous zinc fingers, separated by a two-amino acid residue hydrophobic linker. The domain name is an acronym of the three genes in which it was first identified. LIM is a protein interaction domain that is involved in binding to many structurally and functionally diverse partners. The LIM domain appeared in eukaryotes sometime prior to the most recent common ancestor of plants, fungi, amoeba and animals. In animal cells, LIM domain-containing proteins often shuttle between the cell nucleus where they can regulate gene expression, and the cytoplasm where they are usually associated with actin cytoskeletal structures involved in connecting cells together and to the surrounding matrix, such as stress fibers, focal adhesions and adherens junctions.

Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene.

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Alpha-actinin-4 is a protein that in humans is encoded by the ACTN4 gene.

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Wiskott–Aldrich syndrome protein family member 1, also known as WASP-family verprolin homologous protein 1 (WAVE1), is a protein that in humans is encoded by the WASF1 gene.

CAP/Ponsin protein, also known as Sorbin and SH3 domain-containing protein 1 is a protein that in humans is encoded by the SORBS1 gene. It is part of a small family of adaptor proteins that regulate cell adhesion, growth factor signaling and cytoskeletal formation. It is mainly expressed in heart, skeletal muscle, liver, adipose tissue, and macrophages; in striated muscle tissue, it is localized to costamere structures.

Cytoplasmic protein NCK2 is a protein that in humans is encoded by the NCK2 gene.

Thyroid receptor-interacting protein 6 is a protein that in humans is encoded by the TRIP6 gene.

Chloride intracellular channel 4, also known as CLIC4,p644H1,HuH1, is a eukaryotic gene.

Ena/VASP-like protein is a member of the Ena/VASP family of proteins that in humans is encoded by the EVL gene.

LIM domain and actin-binding protein 1 is a protein that in humans is encoded by the LIMA1 gene.

TRIO and F-actin-binding protein is a protein that in humans is encoded by the TRIOBP gene.

PDZ and LIM domain protein 7 is a protein that in humans is encoded by the PDLIM7 gene.

Vinexin is a protein that in humans is encoded by the SORBS3 gene.

PDZ and LIM domain protein 4 is a protein that in humans is encoded by the PDLIM4 gene.

Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000002834 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038366 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tomasetto C, Regnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC (Jan 1996). "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17". Genomics. 28 (3): 367–76. doi:10.1006/geno.1995.1163. PMID 7490069.
1 2 "Entrez Gene: LASP1 LIM and SH3 protein 1".
↑ Li, Bo; Zhuang Lei; Trueb Beat (May 2004). "Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1". J. Biol. Chem. United States. 279 (19): 20401–10. doi: 10.1074/jbc.M310304200 . ISSN 0021-9258. PMID 15004028.

Tomasetto C, Moog-Lutz C, Régnier CH, et al. (1995). "Lasp-1 (MLN 50) defines a new LIM protein subfamily characterized by the association of LIM and SH3 domains". FEBS Lett. 373 (3): 245–9. doi: 10.1016/0014-5793(95)01040-L . PMID 7589475. S2CID 648563.
Chew CS, Parente JA, Zhou C, et al. (1998). "Lasp-1 is a regulated phosphoprotein within the cAMP signaling pathway in the gastric parietal cell". Am. J. Physiol. 275 (1 Pt 1): C56–67. doi:10.1152/ajpcell.1998.275.1.C56. PMID 9688835.
Schreiber V, Moog-Lutz C, Régnier CH, et al. (1999). "Lasp-1, a novel type of actin-binding protein accumulating in cell membrane extensions". Mol. Med. 4 (10): 675–87. doi:10.1007/BF03401929. PMC 2230251 . PMID 9848085.
Chew CS, Chen X, Parente JA, et al. (2003). "Lasp-1 binds to non-muscle F-actin in vitro and is localized within multiple sites of dynamic actin assembly in vivo". J. Cell Sci. 115 (Pt 24): 4787–99. doi:10.1242/jcs.00174. PMID 12432067.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Butt E, Gambaryan S, Göttfert N, et al. (2003). "Actin binding of human LIM and SH3 protein is regulated by cGMP- and cAMP-dependent protein kinase phosphorylation on serine 146". J. Biol. Chem. 278 (18): 15601–7. doi: 10.1074/jbc.M209009200 . PMID 12571245.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Li B, Zhuang L, Trueb B (2004). "Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1". J. Biol. Chem. 279 (19): 20401–10. doi: 10.1074/jbc.M310304200 . PMID 15004028.
Keicher C, Gambaryan S, Schulze E, et al. (2004). "Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase". Biochem. Biophys. Res. Commun. 324 (1): 308–16. doi:10.1016/j.bbrc.2004.08.235. PMID 15465019.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384. S2CID 20475874.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Grunewald TG, Kammerer U, Schulze E, et al. (2006). "Silencing of LASP-1 influences zyxin localization, inhibits proliferation and reduces migration in breast cancer cells". Exp. Cell Res. 312 (7): 974–82. doi:10.1016/j.yexcr.2005.12.016. PMID 16430883.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000002834 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038366 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7490069-5] Tomasetto C, Regnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC (Jan 1996). "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17". Genomics. 28 (3): 367–76. doi:10.1006/geno.1995.1163. PMID 7490069.

[entrez-6] 1 2 "Entrez Gene: LASP1 LIM and SH3 protein 1".

[pmid15004028-7] Li, Bo; Zhuang Lei; Trueb Beat (May 2004). "Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1". J. Biol. Chem. United States. 279 (19): 20401–10. doi: 10.1074/jbc.M310304200 . ISSN 0021-9258. PMID 15004028.

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LASP1

Contents

Interactions

Related Research Articles

References

Further reading