LCORL | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | LCORL , MLR1, ligand dependent nuclear receptor corepressor like | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 611799 MGI: 2651932 HomoloGene: 82325 GeneCards: LCORL | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Ligand dependent nuclear receptor corepressor like is a protein that in humans is encoded by the LCORL gene. [5]
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The ARNT gene encodes the aryl hydrocarbon receptor nuclear translocator protein that forms a complex with ligand-bound aryl hydrocarbon receptor (AhR), and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.