LDB2

LDB2
Identifiers
Aliases	LDB2 , CLIM1, LDB1, LDB-2, LIM domain binding 2
External IDs	OMIM: 603450 MGI: 894670 HomoloGene: 989 GeneCards: LDB2
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4p15.32 Start 16,501,541 bp [1] End 16,898,678 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 B3 Start 44,629,474 bp [2] End 44,957,022 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung Brodmann area 23 middle temporal gyrus superior frontal gyrus vena cava Brodmann area 10 frontal pole Achilles tendon upper lobe of left lung pericardium Top expressed in subiculum vas deferens dorsomedial hypothalamic nucleus ventromedial nucleus left lung Region I of hippocampus proper left lung lobe primary motor cortex inferior colliculus right lung More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme binding LIM domain binding transcription coregulator activity protein binding Cellular component nucleus transcription regulator complex cell leading edge nucleolus plasma membrane Biological process regulation of transcription by RNA polymerase II hair follicle development positive regulation of cellular component biogenesis epithelial structure maintenance somatic stem cell population maintenance positive regulation of transcription by RNA polymerase II regulation of kinase activity regulation of cell migration negative regulation of transcription by RNA polymerase II multicellular organism development negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9079 16826 Ensembl ENSG00000169744 ENSMUSG00000039706 UniProt O43679 O55203 RefSeq (mRNA) NM_001130834 NM_001290 NM_001304434 NM_001304435 NM_001077398 NM_001286348 NM_010698 NM_001347349 NM_001359070 NM_001359071 RefSeq (protein) NP_001124306 NP_001281 NP_001291363 NP_001291364 NP_001070866 NP_001273277 NP_001334278 NP_034828 NP_001345999 NP_001346000 Location (UCSC) Chr 4: 16.5 – 16.9 Mb Chr 5: 44.63 – 44.96 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

LIM domain-binding protein 2 is a protein that in humans is encoded by the LDB2 gene. ^{[5] [6] [7] [8]}

See also

• LIM domain
• LIM domain-binding protein family

References

1. GRCh38: Ensembl release 89: ENSG00000169744 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039706 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M (Feb 1999). "Selection system for genes encoding nuclear-targeted proteins". Nat Biotechnol. 16 (13): 1338–42. doi:10.1038/4315. PMID   9853615. S2CID   20001769.
6. Retaux S, Rogard M, Bach I, Failli V, Besson MJ (Feb 1999). "Lhx9: a novel LIM-homeodomain gene expressed in the developing forebrain". J Neurosci. 19 (2): 783–93. doi:10.1523/JNEUROSCI.19-02-00783.1999. PMC   6782204 . PMID   9880598.
7. Kotaka M, Kostin S, Ngai S, Chan K, Lau Y, Lee SM, Li H, Ng EK, Schaper J, Tsui SK, Fung K, Lee C, Waye MM (Oct 2000). "Interaction of hCLIM1, an enigma family protein, with alpha-actinin 2". J Cell Biochem. 78 (4): 558–65. doi:10.1002/1097-4644(20000915)78:4<558::AID-JCB5>3.0.CO;2-I. PMID   10861853. S2CID   84122657.
8. "Entrez Gene: LDB2 LIM domain binding 2".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Semina EV, Altherr MR, Murray JC (1998). "Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI". Mamm. Genome. 9 (11): 921–4. doi:10.1007/s003359900899. PMID   9799849. S2CID   28813194.
• Ueki N, Seki N, Yano K, et al. (1999). "Isolation and chromosomal assignment of human genes encoding cofactor of LIM homeodomain proteins, CLIM1 and CLIM2". J. Hum. Genet. 44 (2): 112–5. doi: 10.1007/s100380050120 . PMID   10083735.
• Bach I, Rodriguez-Esteban C, Carrière C, et al. (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nat. Genet. 22 (4): 394–9. doi:10.1038/11970. PMID   10431247. S2CID   22326394.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.