LECT1

CNMD
Identifiers
Aliases	CNMD , BRICD3, CHM-I, CHM1, MYETS1, LECT1, leukocyte cell derived chemotaxin 1, chondromodulin
External IDs	OMIM: 605147; MGI: 1341171; HomoloGene: 5095; GeneCards: CNMD; OMA:CNMD - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q14.3 Start 52,703,264 bp [1] End 52,739,820 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 D3 Start 79,875,130 bp [2] End 79,899,610 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia cartilage tissue testicle ventricular zone gonad ganglionic eminence nucleus accumbens caudate nucleus retinal pigment epithelium putamen Top expressed in vestibular membrane of cochlear duct vestibular sensory epithelium saccule cochlea human fetus lumbar spinal ganglion trachea intercostal muscle calvaria utricle More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 11061 16840 Ensembl ENSG00000136110 ENSMUSG00000022025 UniProt O75829 Q9Z1F6 RefSeq (mRNA) NM_001011705 NM_007015 NM_010701 NM_001310655 RefSeq (protein) NP_001011705 NP_008946 NP_001297584 NP_034831 Location (UCSC) Chr 13: 52.7 – 52.74 Mb Chr 14: 79.88 – 79.9 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Chondromodulin-1 is a protein that in humans is encoded by the LECT1 gene. ^{[5] [6] [7]}

Function

This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein, although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage, and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may also be involved in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. ^[7]

Chondromodulin-I, an antiangiogenic factor isolated from cartilage, is abundantly expressed in cardiac valves. Gene targeting of chondromodulin-I resulted in enhanced VEGF-A expression, angiogenesis, lipid deposition and calcification in the cardiac valves of aged mice. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000136110 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022025 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shukunami C, Hiraki Y (August 1998). "Expression of cartilage-specific functional matrix chondromodulin-I mRNA in rabbit growth plate chondrocytes and its responsiveness to growth stimuli in vitro". Biochemical and Biophysical Research Communications. 249 (3): 885–90. doi:10.1006/bbrc.1998.9233. PMID   9731231.
6. Hiraki Y, Mitsui K, Endo N, Takahashi K, Hayami T, Inoue H, Shukunami C, Tokunaga K, Kono T, Yamada M, Takahashi HE, Kondo J (March 1999). "Molecular cloning of human chondromodulin-I, a cartilage-derived growth modulating factor, and its expression in Chinese hamster ovary cells". European Journal of Biochemistry. 260 (3): 869–78. doi: 10.1046/j.1432-1327.1999.00227.x . PMID   10103018.
7. "Entrez Gene: LECT1 leukocyte cell derived chemotaxin 1".
8. Yoshioka M, Yuasa S, Matsumura K, Kimura K, Shiomi T, Kimura N, Shukunami C, Okada Y, Mukai M, Shin H, Yozu R, Sata M, Ogawa S, Hiraki Y, Fukuda K (October 2006). "Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis". Nature Medicine. 12 (10): 1151–9. doi:10.1038/nm1476. PMID   16980969. S2CID   7704603.

Further reading

• Hiraki Y, Shukunami C (July 2000). "Chondromodulin-I as a novel cartilage-specific growth-modulating factor". Pediatric Nephrology. 14 (7): 602–5. doi:10.1007/s004670000339. PMID   10912526. S2CID   20707816.
• Hayami T, Shukunami C, Mitsui K, Endo N, Tokunaga K, Kondo J, Takahashi HE, Hiraki Y (September 1999). "Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo". FEBS Letters. 458 (3): 436–40. doi:10.1016/S0014-5793(99)01201-6. PMID   10570955. S2CID   31317770.
• Yanagihara I, Yamagata M, Sakai N, Shukunami C, Kurahashi H, Yamazaki M, Michigami T, Hiraki Y, Ozono K (March 2000). "Genomic organization of the human chondromodulin-1 gene containing a promoter region that confers the expression of reporter gene in chondrogenic ATDC5 cells". Journal of Bone and Mineral Research. 15 (3): 421–9. doi: 10.1359/jbmr.2000.15.3.421 . PMID   10750556.
• Azizan A, Holaday N, Neame PJ (June 2001). "Post-translational processing of bovine chondromodulin-I". The Journal of Biological Chemistry. 276 (26): 23632–8. doi: 10.1074/jbc.M009967200 . PMID   11323410.
• Aoyama T, Okamoto T, Nagayama S, Nishijo K, Ishibe T, Yasura K, Tsuboyama T, Nakayama T, Nakashima Y, Nakamura T, Toguchida J (February 2004). "Expression of the chondromodulin-I gene in chondrosarcomas". Cancer Letters. 204 (1): 61–8. doi:10.1016/j.canlet.2003.09.015. hdl: 2433/147532 . PMID   14744535.
• Aoyama T, Okamoto T, Nagayama S, Nishijo K, Ishibe T, Yasura K, Nakayama T, Nakamura T, Toguchida J (July 2004). "Methylation in the core-promoter region of the chondromodulin-I gene determines the cell-specific expression by regulating the binding of transcriptional activator Sp3". The Journal of Biological Chemistry. 279 (27): 28789–97. doi: 10.1074/jbc.M401273200 . PMID   15107420.