LEPREL2

P3H3
Identifiers
Aliases	P3H3 , GRCB, HSU47926, LEPREL2, prolyl 3-hydroxylase 3
External IDs	OMIM: 610342; MGI: 1315208; HomoloGene: 8401; GeneCards: P3H3; OMA:P3H3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p13.31 Start 6,828,407 bp [1] End 6,839,847 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 F2|6 59.17 cM Start 124,841,089 bp [2] End 124,857,752 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium anterior pituitary right hemisphere of cerebellum body of uterus apex of heart right ovary ascending aorta Descending thoracic aorta left ovary canal of the cervix Top expressed in calvaria saccule external carotid artery ascending aorta aortic valve internal carotid artery vas deferens dermis neural layer of retina fossa More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen L-ascorbic acid binding dioxygenase activity iron ion binding oxidoreductase activity metal ion binding procollagen-proline 3-dioxygenase activity Cellular component endoplasmic reticulum catalytic complex Biological process negative regulation of cell population proliferation peptidyl-proline hydroxylation collagen metabolic process peptidyl-lysine hydroxylation collagen biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10536 14789 Ensembl ENSG00000110811 ENSMUSG00000023191 UniProt Q8IVL6 Q8CG70 RefSeq (mRNA) NM_014262 NM_013534 RefSeq (protein) NP_055077 NP_038562 Location (UCSC) Chr 12: 6.83 – 6.84 Mb Chr 6: 124.84 – 124.86 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Prolyl 3-hydroxylase 3 is an enzyme that in humans is encoded by the LEPREL2 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000110811 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023191 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jarnum S, Kjellman C, Darabi A, Nilsson I, Edvardsen K, Aman P (Apr 2004). "LEPREL1, a novel ER and Golgi resident member of the Leprecan family". Biochem Biophys Res Commun. 317 (2): 342–51. doi:10.1016/j.bbrc.2004.03.060. PMID   15063763.
6. "Entrez Gene: LEPREL2 leprecan-like 2".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Vranka JA, Sakai LY, Bächinger HP (2004). "Prolyl 3-hydroxylase 1, enzyme characterization and identification of a novel family of enzymes". J. Biol. Chem. 279 (22): 23615–21. doi: 10.1074/jbc.M312807200 . PMID   15044469.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ansari-Lari MA, Shen Y, Muzny DM, et al. (1997). "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination". Genome Res. 7 (3): 268–80. doi: 10.1101/gr.7.3.268 . PMID   9074930.
• Ansari-Lari MA, Muzny DM, Lu J, et al. (1996). "A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13". Genome Res. 6 (4): 314–26. doi: 10.1101/gr.6.4.314 . PMID   8723724.