LIMA1

LIMA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D8Y
Identifiers
Aliases	LIMA1 , EPLIN, SREBP3, LIM domain and actin binding 1, LDLCQ8
External IDs	OMIM: 608364 MGI: 1920992 HomoloGene: 9484 GeneCards: LIMA1
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.12 Start 50,175,788 bp [1] End 50,283,546 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15 F1|15 56.13 cM Start 99,676,351 bp [2] End 99,773,337 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte Achilles tendon rectum subcutaneous adipose tissue jejunal mucosa gastric mucosa gallbladder abdominal fat pylorus Top expressed in lacrimal gland left colon epithelium of stomach duodenum pyloric antrum corneal stroma calvaria seminal vesicula jejunum mucous cell of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin filament binding actin binding actin monomer binding protein binding metal ion binding cadherin binding Cellular component cell junction cleavage furrow cytoskeleton brush border stress fiber focal adhesion actin cytoskeleton cytoplasm Biological process negative regulation of actin filament depolymerization ruffle organization actin filament bundle assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51474 65970 Ensembl ENSG00000050405 ENSMUSG00000023022 UniProt Q9UHB6 Q9ERG0 RefSeq (mRNA) NM_001113546 NM_001113547 NM_001243775 NM_016357 NM_001113545 NM_023063 RefSeq (protein) NP_001107018 NP_001107019 NP_001230704 NP_057441 NP_001107017 NP_075550 Location (UCSC) Chr 12: 50.18 – 50.28 Mb Chr 15: 99.68 – 99.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

LIM domain and actin-binding protein 1 is a protein that in humans is encoded by the LIMA1 gene. ^{[5] [6] [7] [8]}

EPLIN is a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles (Maul et al., 2003).[supplied by OMIM] ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000050405 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023022 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chen S, Maul RS, Kim HR, Chang DD (Jul 2000). "Characterization of the human EPLIN (Epithelial Protein Lost in Neoplasm) gene reveals distinct promoters for the two EPLIN isoforms". Gene. 248 (1–2): 69–76. doi:10.1016/S0378-1119(00)00144-X. PMID   10806352.
6. Maul RS, Chang DD (Feb 2000). "EPLIN, epithelial protein lost in neoplasm". Oncogene. 18 (54): 7838–41. doi: 10.1038/sj.onc.1203206 . PMID   10618726.
7. Maul RS, Song Y, Amann KJ, Gerbin SC, Pollard TD, Chang DD (Feb 2003). "EPLIN regulates actin dynamics by cross-linking and stabilizing filaments". J Cell Biol. 160 (3): 399–407. doi:10.1083/jcb.200212057. PMC   2172667 . PMID   12566430.
8. "Entrez Gene: LIMA1 LIM domain and actin binding 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi: 10.1073/pnas.160270997 . PMC   16901 . PMID   10931946.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi: 10.1016/j.cub.2004.07.051 . PMID   15324660. S2CID   2371325.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC   524842 . PMID   15498874.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID   16083285.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.