LIMCH1

LIMCH1
Identifiers
Aliases	LIMCH1 , LIMCH1A, LMO7B, LIM and calponin homology domains 1
External IDs	OMIM: 617750; MGI: 1924819; HomoloGene: 18953; GeneCards: LIMCH1; OMA:LIMCH1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4p13 Start 41,359,607 bp [1] End 41,700,044 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 C3.1 Start 66,745,827 bp [2] End 67,057,158 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung internal globus pallidus inferior ganglion of vagus nerve olfactory bulb corpus callosum dorsal motor nucleus of vagus nerve inferior olivary nucleus subthalamic nucleus superior vestibular nucleus external globus pallidus Top expressed in sciatic nerve left lung right lung left lung lobe right lung lobe retinal pigment epithelium epithelium of lens myocardium of ventricle right ventricle ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding metal ion binding myosin II head/neck binding Cellular component stress fiber myosin II complex cytoplasm cytoskeleton Biological process actomyosin structure organization positive regulation of protein phosphorylation negative regulation of cell migration positive regulation of stress fiber assembly regulation of focal adhesion assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22998 77569 Ensembl ENSG00000064042 ENSMUSG00000037736 UniProt Q9UPQ0 Q3UH68 RefSeq (mRNA) NM_001112717 NM_001112718 NM_001112719 NM_001112720 NM_001289122 NM_001289124 NM_014988 NM_001330672 NM_001330674 NM_001330784 NM_001330786 NM_001330787 NM_001330788 NM_001330789 NM_001330790 NM_001330791 NM_001330792 NM_001330793 NM_001330982 NM_001330983 NM_001001980 NM_001256122 NM_001368863 RefSeq (protein) NP_001106188 NP_001106189 NP_001106190 NP_001106191 NP_001276051 NP_001276053 NP_001317601 NP_001317603 NP_001317713 NP_001317715 NP_001317716 NP_001317717 NP_001317718 NP_001317719 NP_001317720 NP_001317721 NP_001317722 NP_001317911 NP_001317912 NP_055803 NP_001001980 NP_001243051 NP_001355792 NP_001388339 NP_001388340 NP_001388341 NP_001388342 NP_001388343 NP_001388344 NP_001388345 NP_001388346 NP_001388347 NP_001388348 NP_001388349 NP_001388350 NP_001388351 NP_001388352 NP_001388353 NP_001388354 NP_001388355 NP_001388356 NP_001390437 NP_001390438 Location (UCSC) Chr 4: 41.36 – 41.7 Mb Chr 5: 66.75 – 67.06 Mb PubMed search [3] [4]
Wikidata
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LIM and calponin homology domains-containing protein 1 is a protein that in humans is encoded by the LIMCH1 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000064042 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037736 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi: 10.1093/dnares/6.3.197 . PMID   10470851.
6. "Entrez Gene: DKFZP686A01247 hypothetical protein".

Further reading

• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.