LIME1

LIME1
Identifiers
Aliases	LIME1 , LIME, LP8067, dJ583P15.4, Lck interacting transmembrane adaptor 1
External IDs	OMIM: 609809 MGI: 1919949 HomoloGene: 56785 GeneCards: LIME1
Gene location (Mouse) Chr. Chromosome 2 (mouse) [1] Band 2|2 H4 Start 181,021,871 bp [1] End 181,025,421 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver blood spleen putamen bone marrow cells kidney caudate nucleus nucleus accumbens pituitary gland hippocampus proper Top expressed in islet of Langerhans spleen bone marrow cerebellar cortex thymus hypothalamus olfactory bulb superior frontal gyrus adrenal gland ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase binding Cellular component integral component of membrane plasma membrane membrane extracellular space U2-type post-mRNA release spliceosomal complex B cell receptor complex Biological process B cell receptor signaling pathway T cell receptor signaling pathway adaptive immune response immune system process spliceosomal complex disassembly regulation of transcription by RNA polymerase II regulation of phosphatidylinositol 3-kinase signaling regulation of I-kappaB kinase/NF-kappaB signaling regulation of MAP kinase activity regulation of release of sequestered calcium ion into cytosol regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54923 72699 Ensembl n/a ENSMUSG00000090077 UniProt Q9H400 Q9EQR5 RefSeq (mRNA) NM_017806 NM_001305654 NM_001305655 NM_023684 RefSeq (protein) NP_001292583 NP_001292584 NP_060276 NP_076173 Location (UCSC) n/a Chr 2: 181.02 – 181.03 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Lck-interacting transmembrane adapter 1 is a protein that in humans is encoded by the LIME1 gene. ^{[4] [5]}

LIME1 is a raft-associated transmembrane adaptor phosphoprotein that is preferentially expressed in hemopoietic cells, particularly T cells (Brdickova et al., 2003; Hur et al., 2003).[supplied by OMIM] ^[5]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000090077 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
5. "Entrez Gene: LIME1 Lck interacting transmembrane adaptor 1".

Further reading

• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Hur EM, Son M, Lee OH, et al. (2004). "LIME, a Novel Transmembrane Adaptor Protein, Associates with p56lck and Mediates T Cell Activation". J. Exp. Med. 198 (10): 1463–73. doi:10.1084/jem.20030232. PMC   2194117 . PMID   14610044.
• Brdicková N, Brdicka T, Angelisová P, et al. (2004). "LIME: A New Membrane Raft-associated Adaptor Protein Involved in CD4 and CD8 Coreceptor Signaling". J. Exp. Med. 198 (10): 1453–62. doi:10.1084/jem.20031484. PMC   2194115 . PMID   14610046.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC   524842 . PMID   15498874.
• Tedoldi S, Paterson JC, Hansmann ML, et al. (2006). "Transmembrane adaptor molecules: a new category of lymphoid-cell markers". Blood. 107 (1): 213–21. doi:10.1182/blood-2005-06-2273. PMID   16160011. S2CID   340034.
• Ahn E, Lee H, Yun Y (2006). "LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation". Blood. 107 (4): 1521–7. doi: 10.1182/blood-2005-05-1859 . PMID   16249387. S2CID   1139121.