LIN7A

LIN7A
Identifiers
Aliases	LIN7A , LIN-7A, LIN7, MALS-1, TIP-33, VELI1, lin-7 homolog A, crumbs cell polarity complex component, MALS1
External IDs	OMIM: 603380; MGI: 2135609; HomoloGene: 20976; GeneCards: LIN7A; OMA:LIN7A - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q21.31 Start 80,792,520 bp [1] End 80,937,934 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 D1 Start 107,107,547 bp [2] End 107,257,335 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 endothelial cell middle temporal gyrus retinal pigment epithelium primary visual cortex trabecular bone blood cerebellar cortex cerebellar hemisphere entorhinal cortex Top expressed in lobe of cerebellum seminiferous tubule cerebellar vermis lateral septal nucleus lumbar spinal ganglion nucleus accumbens neural layer of retina primary motor cortex inferior colliculi superior cervical ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding L27 domain binding Cellular component postsynaptic membrane membrane postsynaptic density cell-cell junction bicellular tight junction plasma membrane cell junction basolateral plasma membrane neuron projection extracellular exosome presynapse synapse MPP7-DLG1-LIN7 complex intracellular anatomical structure Biological process protein localization to basolateral plasma membrane maintenance of epithelial cell apical/basal polarity protein transport synaptic vesicle transport inner ear development neurotransmitter secretion exocytosis transport protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8825 108030 Ensembl ENSG00000111052 ENSMUSG00000019906 UniProt O14910 Q8JZS0 RefSeq (mRNA) NM_004664 NM_001324423 NM_001033223 NM_001039354 NM_001284329 RefSeq (protein) NP_001311352 NP_004655 NP_001028395 NP_001034443 NP_001271258 Location (UCSC) Chr 12: 80.79 – 80.94 Mb Chr 10: 107.11 – 107.26 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Lin-7 homolog A is a protein that in humans is encoded by the LIN7A gene. ^{[5] [6] [7]}

Interactions

LIN7A has been shown to interact with:

• CASK, ^{[8] [9]}
• DLG1, ^[8] and
• KCNJ12. ^{[8] [10]}

References

1. GRCh38: Ensembl release 89: ENSG00000111052 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019906 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. doi: 10.1523/JNEUROSCI.19-11-04189.1999 . PMC   6782594 . PMID   10341223.
6. Bohl J, Brimer N, Lyons C, Vande Pol SB (Mar 2007). "The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions". J Biol Chem. 282 (13): 9392–400. doi: 10.1074/jbc.M610002200 . PMID   17237226.
7. "Entrez Gene: LIN7A lin-7 homolog A (C. elegans)".
8. Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi: 10.1074/jbc.M400284200 . PMID   14960569.
9. Borg JP, Straight SW, Kaech SM, de Taddéo-Borg M, Kroon DE, Karnak D, Turner RS, Kim SK, Margolis B (Nov 1998). "Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting". J. Biol. Chem. 273 (48): 31633–6. doi: 10.1074/jbc.273.48.31633 . PMID   9822620.
10. Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi: 10.1074/jbc.M400285200 . PMID   15024025.

Further reading

• Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P (1998). "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins". Oncogene. 16 (5): 643–54. doi: 10.1038/sj.onc.1201567 . PMID   9482110.
• Butz S, Okamoto M, Südhof TC (1998). "A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain". Cell. 94 (6): 773–82. doi: 10.1016/S0092-8674(00)81736-5 . PMID   9753324. S2CID   12465062.
• Borg JP, Straight SW, Kaech SM, de Taddéo-Borg M, Kroon DE, Karnak D, Turner RS, Kim SK, Margolis B (1998). "Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting". J. Biol. Chem. 273 (48): 31633–6. doi: 10.1074/jbc.273.48.31633 . PMID   9822620.
• Borg JP, Lõpez-Figueroa MO, de Taddèo-Borg M, Kroon DE, Turner RS, Watson SJ, Margolis B (1999). "Molecular analysis of the X11-mLin-2/CASK complex in brain". J. Neurosci. 19 (4): 1307–16. doi: 10.1523/JNEUROSCI.19-04-01307.1999 . PMC   6786035 . PMID   9952408.
• Perego C, Vanoni C, Villa A, Longhi R, Kaech SM, Fröhli E, Hajnal A, Kim SK, Pietrini G (1999). "PDZ-mediated interactions retain the epithelial GABA transporter on the basolateral surface of polarized epithelial cells". EMBO J. 18 (9): 2384–93. doi:10.1093/emboj/18.9.2384. PMC   1171321 . PMID   10228153.
• Kamberov E, Makarova O, Roh M, Liu A, Karnak D, Straight S, Margolis B (2000). "Molecular cloning and characterization of Pals, proteins associated with mLin-7". J. Biol. Chem. 275 (15): 11425–31. doi: 10.1074/jbc.275.15.11425 . PMID   10753959.
• Tseng TC, Marfatia SM, Bryant PJ, Pack S, Zhuang Z, O'Brien JE, Lin L, Hanada T, Chishti AH (2001). "VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain". Biochim. Biophys. Acta. 1518 (3): 249–59. doi:10.1016/s0167-4781(01)00191-9. PMID   11311936.
• Harris BZ, Venkatasubrahmanyam S, Lim WA (2002). "Coordinated folding and association of the LIN-2, -7 (L27) domain. An obligate heterodimerization involved in assembly of signaling and cell polarity complexes". J. Biol. Chem. 277 (38): 34902–8. doi: 10.1074/jbc.M205856200 . PMID   12110687.
• Hori K, Konno D, Maruoka H, Sobue K (2003). "MALS is a binding partner of IRSp53 at cell-cell contacts". FEBS Lett. 554 (1–2): 30–4. doi: 10.1016/S0014-5793(03)01074-3 . PMID   14596909. S2CID   30329043.
• Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi: 10.1074/jbc.M400284200 . PMID   14960569.
• Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi: 10.1074/jbc.M400285200 . PMID   15024025.
• Olsen O, Wade JB, Morin N, Bredt DS, Welling PA (2005). "Differential localization of mammalian Lin-7 (MALS/Veli) PDZ proteins in the kidney". Am. J. Physiol. Renal Physiol. 288 (2): F345–52. doi:10.1152/ajprenal.00235.2004. PMID   15494546. S2CID   36221552.
• Dode L, Andersen JP, Raeymaekers L, Missiaen L, Vilsen B, Wuytack F (2006). "Functional comparison between secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and sarcoplasmic reticulum Ca2+-ATPase (SERCA) 1 isoforms by steady-state and transient kinetic analyses". J. Biol. Chem. 280 (47): 39124–34. doi: 10.1074/jbc.M506181200 . PMID   16192278.