LIN7A

LIN7A
Identifiers
Aliases	LIN7A , LIN-7A, LIN7, MALS-1, TIP-33, VELI1, lin-7 homolog A, crumbs cell polarity complex component, MALS1
External IDs	OMIM: 603380 MGI: 2135609 HomoloGene: 20976 GeneCards: LIN7A
Gene location (Human)
Chr.	Chromosome 12 (human)
End	80,937,934 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	107,257,335 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; endothelial cell; ; middle temporal gyrus; ; retinal pigment epithelium; ; cancellous bone; ; blood; ; cerebellar cortex; ; cerebellar hemisphere; ; entorhinal cortex; ; bone marrow;
	Top expressed in
	seminiferous tubule; ; cerebellar vermis; ; nucleus accumbens; ; primary motor cortex; ; inferior colliculus; ; superior cervical ganglion; ; mammillary body; ; spermatocyte; ; Region I of hippocampus proper; ; spermatid;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; L27 domain binding ;
Cellular component	postsynaptic membrane ; membrane ; postsynaptic density ; cell-cell junction ; bicellular tight junction ; plasma membrane ; cell junction ; basolateral plasma membrane ; neuron projection ; extracellular exosome ; presynapse ; synapse ; MPP7-DLG1-LIN7 complex ; intracellular anatomical structure ;
Biological process	protein localization to basolateral plasma membrane ; maintenance of epithelial cell apical/basal polarity ; protein transport ; synaptic vesicle transport ; inner ear development ; neurotransmitter secretion ; exocytosis ; transport ; protein-containing complex assembly ;
	Sources:Amigo / QuickGO
Orthologs
	8825
	108030
	ENSG00000111052
	ENSMUSG00000019906
	O14910
	Q8JZS0
	NM_004664 ; NM_001324423
	NM_001033223 ; NM_001039354 ; NM_001284329
	NP_001311352 ; NP_004655
	NP_001028395 ; NP_001034443 ; NP_001271258
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 02, 2023

Lin-7 homolog A is a protein that in humans is encoded by the LIN7A gene.^[5]^[6]^[7]

Interactions

LIN7A has been shown to interact with:

Related Research Articles

The renal outer medullary potassium channel (ROMK) is an ATP-dependent potassium channel (K_ir1.1) that transports potassium out of cells. It plays an important role in potassium recycling in the thick ascending limb (TAL) and potassium secretion in the cortical collecting duct (CCD) of the nephron. In humans, ROMK is encoded by the KCNJ1 gene. Multiple transcript variants encoding different isoforms have been found for this gene.

The K_ir2.1 inward-rectifier potassium channel is a lipid-gated ion channel encoded by the KCNJ2 gene.

Erbb2 interacting protein (ERBB2IP), also known as erbin, is a protein which in humans is encoded by the ERBB2IP gene. Discovered in 1997, erbin is a 200kDa protein containing a PDZ domain.

PSD-95 also known as SAP-90 is a protein that in humans is encoded by the DLG4 gene.

Peripheral plasma membrane protein CASK is a protein that in humans is encoded by the CASK gene. This gene is also known by several other names: CMG 2, calcium/calmodulin-dependent serine protein kinase 3 and membrane-associated guanylate kinase 2. CASK gene mutations are the cause of XL-ID with or without nystagmus and MICPCH, an X-linked neurological disorder.

Disks large homolog 3 (DLG3) also known as neuroendocrine-DLG or synapse-associated protein 102 (SAP-102) is a protein that in humans is encoded by the DLG3 gene. DLG3 is a member of the membrane-associated guanylate kinase (MAGUK) superfamily of proteins.

Disks large homolog 2 (DLG2) also known as channel-associated protein of synapse-110 (chapsyn-110) or postsynaptic density protein 93 (PSD-93) is a protein that in humans is encoded by the DLG2 gene.

Amyloid beta A4 precursor protein-binding family A member 1 is a protein that in humans is encoded by the APBA1 gene.

G protein-activated inward rectifier potassium channel 2 is a protein that in humans is encoded by the KCNJ6 gene. Mutation in KCNJ6 gene has been proposed to be the cause of Keppen-Lubinsky Syndrome (KPLBS).

Amyloid beta A4 precursor protein-binding family A member 2 is a protein that in humans is encoded by the APBA2 gene.

Potassium inwardly-rectifying channel, subfamily J, member 4, also known as KCNJ4 or K_ir2.3, is a human gene.

Beta-2-syntrophin is a protein that in humans is encoded by the SNTB2 gene.

InaD-like protein is a protein that in humans is encoded by the PATJ gene.

ATP-sensitive inward rectifier potassium channel 12 is a lipid-gated ion channel that in humans is encoded by the KCNJ12 gene.

Beta-1-syntrophin is a protein that in humans is encoded by the SNTB1 gene.

MAGUK p55 subfamily member 6 is a protein that in humans is encoded by the MPP6 gene.

Potassium inwardly-rectifying channel, subfamily J, member 15, also known as KCNJ15 is a human gene, which encodes the K_ir4.2 protein.

Lin-7 homolog B is a protein that in humans is encoded by the LIN7B gene.

Lin-7 homolog C is a protein that in humans is encoded by the LIN7C gene.

Potassium inwardly-rectifying channel, subfamily J, member 16 (KCNJ16) is a human gene encoding the K_ir5.1 protein.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000111052 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019906 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. doi: 10.1523/JNEUROSCI.19-11-04189.1999 . PMC 6782594 . PMID 10341223.
↑ Bohl J, Brimer N, Lyons C, Vande Pol SB (Mar 2007). "The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions". J Biol Chem. 282 (13): 9392–400. doi: 10.1074/jbc.M610002200 . PMID 17237226.
↑ "Entrez Gene: LIN7A lin-7 homolog A (C. elegans)".
1 2 3 Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi: 10.1074/jbc.M400284200 . PMID 14960569.
↑ Borg JP, Straight SW, Kaech SM, de Taddéo-Borg M, Kroon DE, Karnak D, Turner RS, Kim SK, Margolis B (Nov 1998). "Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting". J. Biol. Chem. 273 (48): 31633–6. doi: 10.1074/jbc.273.48.31633 . PMID 9822620.
↑ Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi: 10.1074/jbc.M400285200 . PMID 15024025.

Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P (1998). "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins". Oncogene. 16 (5): 643–54. doi: 10.1038/sj.onc.1201567 . PMID 9482110.
Butz S, Okamoto M, Südhof TC (1998). "A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain". Cell. 94 (6): 773–82. doi: 10.1016/S0092-8674(00)81736-5 . PMID 9753324. S2CID 12465062.
Borg JP, Straight SW, Kaech SM, de Taddéo-Borg M, Kroon DE, Karnak D, Turner RS, Kim SK, Margolis B (1998). "Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting". J. Biol. Chem. 273 (48): 31633–6. doi: 10.1074/jbc.273.48.31633 . PMID 9822620.
Borg JP, Lõpez-Figueroa MO, de Taddèo-Borg M, Kroon DE, Turner RS, Watson SJ, Margolis B (1999). "Molecular analysis of the X11-mLin-2/CASK complex in brain". J. Neurosci. 19 (4): 1307–16. doi: 10.1523/JNEUROSCI.19-04-01307.1999 . PMC 6786035 . PMID 9952408.
Perego C, Vanoni C, Villa A, Longhi R, Kaech SM, Fröhli E, Hajnal A, Kim SK, Pietrini G (1999). "PDZ-mediated interactions retain the epithelial GABA transporter on the basolateral surface of polarized epithelial cells". EMBO J. 18 (9): 2384–93. doi:10.1093/emboj/18.9.2384. PMC 1171321 . PMID 10228153.
Kamberov E, Makarova O, Roh M, Liu A, Karnak D, Straight S, Margolis B (2000). "Molecular cloning and characterization of Pals, proteins associated with mLin-7". J. Biol. Chem. 275 (15): 11425–31. doi: 10.1074/jbc.275.15.11425 . PMID 10753959.
Tseng TC, Marfatia SM, Bryant PJ, Pack S, Zhuang Z, O'Brien JE, Lin L, Hanada T, Chishti AH (2001). "VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain". Biochim. Biophys. Acta. 1518 (3): 249–59. doi:10.1016/s0167-4781(01)00191-9. PMID 11311936.
Harris BZ, Venkatasubrahmanyam S, Lim WA (2002). "Coordinated folding and association of the LIN-2, -7 (L27) domain. An obligate heterodimerization involved in assembly of signaling and cell polarity complexes". J. Biol. Chem. 277 (38): 34902–8. doi: 10.1074/jbc.M205856200 . PMID 12110687.
Hori K, Konno D, Maruoka H, Sobue K (2003). "MALS is a binding partner of IRSp53 at cell-cell contacts". FEBS Lett. 554 (1–2): 30–4. doi: 10.1016/S0014-5793(03)01074-3 . PMID 14596909. S2CID 30329043.
Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi: 10.1074/jbc.M400284200 . PMID 14960569.
Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi: 10.1074/jbc.M400285200 . PMID 15024025.
Olsen O, Wade JB, Morin N, Bredt DS, Welling PA (2005). "Differential localization of mammalian Lin-7 (MALS/Veli) PDZ proteins in the kidney". Am. J. Physiol. Renal Physiol. 288 (2): F345–52. doi:10.1152/ajprenal.00235.2004. PMID 15494546. S2CID 36221552.
Dode L, Andersen JP, Raeymaekers L, Missiaen L, Vilsen B, Wuytack F (2006). "Functional comparison between secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and sarcoplasmic reticulum Ca2+-ATPase (SERCA) 1 isoforms by steady-state and transient kinetic analyses". J. Biol. Chem. 280 (47): 39124–34. doi: 10.1074/jbc.M506181200 . PMID 16192278.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000111052 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019906 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10341223-5] Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. doi: 10.1523/JNEUROSCI.19-11-04189.1999 . PMC 6782594 . PMID 10341223.

[pmid17237226-6] Bohl J, Brimer N, Lyons C, Vande Pol SB (Mar 2007). "The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions". J Biol Chem. 282 (13): 9392–400. doi: 10.1074/jbc.M610002200 . PMID 17237226.

[entrez-7] "Entrez Gene: LIN7A lin-7 homolog A (C. elegans)".

[pmid14960569-8] 1 2 3 Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi: 10.1074/jbc.M400284200 . PMID 14960569.

[pmid9822620-9] Borg JP, Straight SW, Kaech SM, de Taddéo-Borg M, Kroon DE, Karnak D, Turner RS, Kim SK, Margolis B (Nov 1998). "Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting". J. Biol. Chem. 273 (48): 31633–6. doi: 10.1074/jbc.273.48.31633 . PMID 9822620.

[pmid15024025-10] Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi: 10.1074/jbc.M400285200 . PMID 15024025.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

LIN7A

Contents

Interactions

Related Research Articles

References

Further reading