LIN7C

LIN7C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LRA
Identifiers
Aliases	LIN7C , LIN-7-C, LIN-7C, MALS-3, MALS3, VELI3, lin-7 homolog C, crumbs cell polarity complex component
External IDs	OMIM: 612332 MGI: 1330839 HomoloGene: 22649 GeneCards: LIN7C
Gene location (Human)
Chr.	Chromosome 11 (human)
End	27,506,769 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	109,731,348 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; retinal pigment epithelium; ; tibia; ; cavity of mouth; ; Brodmann area 23; ; visceral pleura; ; parietal pleura; ; kidney tubule; ; seminal vesicula; ; secondary oocyte;
	Top expressed in
	olfactory epithelium; ; medial ganglionic eminence; ; median eminence; ; pineal gland; ; cerebellar vermis; ; dentate gyrus; ; superior cervical ganglion; ; left colon; ; sciatic nerve; ; retinal pigment epithelium;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding ; cytoskeletal protein binding ; L27 domain binding ; PDZ domain binding ;
Cellular component	cytoplasm ; postsynaptic membrane ; postsynaptic density ; membrane ; cell-cell junction ; bicellular tight junction ; plasma membrane ; MPP7-DLG1-LIN7 complex ; cell junction ; basolateral plasma membrane ; neuron projection ; presynapse ; synapse ; glutamatergic synapse ;
Biological process	protein localization to basolateral plasma membrane ; maintenance of epithelial cell apical/basal polarity ; protein transport ; morphogenesis of an epithelial sheet ; neurotransmitter secretion ; exocytosis ;
	Sources:Amigo / QuickGO
Orthologs
	55327
	22343
	ENSG00000148943
	ENSMUSG00000027162
	Q9NUP9
	O88952
	NM_018362
	NM_011699
	NP_060832
	NP_035829
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Lin-7 homolog C is a protein that in humans is encoded by the LIN7C gene.^[5]^[6]

Interactions

LIN7C has been shown to interact with:

Related Research Articles

The renal outer medullary potassium channel (ROMK) is an ATP-dependent potassium channel (K_ir1.1) that transports potassium out of cells. It plays an important role in potassium recycling in the thick ascending limb (TAL) and potassium secretion in the cortical collecting duct (CCD) of the nephron. In humans, ROMK is encoded by the KCNJ1 gene. Multiple transcript variants encoding different isoforms have been found for this gene.

The K_ir2.1 inward-rectifier potassium channel is a lipid-gated ion channel encoded by the KCNJ2 gene.

PSD-95 also known as SAP-90 is a protein that in humans is encoded by the DLG4 gene.

Peripheral plasma membrane protein CASK is a protein that in humans is encoded by the CASK gene. This gene is also known by several other names: CMG 2, calcium/calmodulin-dependent serine protein kinase 3 and membrane-associated guanylate kinase 2. CASK gene mutations are the cause of XL-ID with our without nystagmus and MICPCH, an X-linked neurological disorder.

Disks large homolog 3 (DLG3) also known as neuroendocrine-DLG or synapse-associated protein 102 (SAP-102) is a protein that in humans is encoded by the DLG3 gene. DLG3 is a member of the membrane-associated guanylate kinase (MAGUK) superfamily of proteins.

Disks large homolog 2 (DLG2) also known as channel-associated protein of synapse-110 (chapsyn-110) or postsynaptic density protein 93 (PSD-93) is a protein that in humans is encoded by the DLG2 gene.

Amyloid beta A4 precursor protein-binding family A member 1 is a protein that in humans is encoded by the APBA1 gene.

G protein-activated inward rectifier potassium channel 2 is a protein that in humans is encoded by the KCNJ6 gene. Mutation in KCNJ6 gene has been proposed to be the cause of Keppen-Lubinsky Syndrome (KPLBS).

Potassium inwardly-rectifying channel, subfamily J, member 4, also known as KCNJ4 or K_ir2.3, is a human gene.

Potassium inwardly-rectifying channel, subfamily J, member 8, also known as KCNJ8, is a human gene encoding the K_ir6.1 protein. A mutation in KCNJ8 has been associated with cardiac arrest in the early repolarization syndrome.

Beta-2-syntrophin is a protein that in humans is encoded by the SNTB2 gene.

ATP-sensitive inward rectifier potassium channel 12 is a lipid-gated ion channel that in humans is encoded by the KCNJ12 gene.

Beta-1-syntrophin is a protein that in humans is encoded by the SNTB1 gene.

G protein-activated inward rectifier potassium channel 1(GIRK-1) is encoded in the human by the gene KCNJ3.

MAGUK p55 subfamily member 6 is a protein that in humans is encoded by the MPP6 gene.

Potassium inwardly-rectifying channel, subfamily J, member 15, also known as KCNJ15 is a human gene, which encodes the K_ir4.2 protein.

Lin-7 homolog A is a protein that in humans is encoded by the LIN7A gene.

Lin-7 homolog B is a protein that in humans is encoded by the LIN7B gene.

Potassium inwardly-rectifying channel, subfamily J, member 16 (KCNJ16) is a human gene encoding the K_ir5.1 protein.

G protein-activated inward rectifier potassium channel 3 is a protein that in humans is encoded by the KCNJ9 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000148943 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027162 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. doi: 10.1523/JNEUROSCI.19-11-04189.1999 . PMC 6782594 . PMID 10341223.
↑ "Entrez Gene: LIN7C lin-7 homolog C (C. elegans)".
1 2 3 Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi: 10.1074/jbc.M400284200 . PMID 14960569.
1 2 Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi: 10.1074/jbc.M400285200 . PMID 15024025.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Bécamel C, Alonso G, Galéotti N, Demey E, Jouin P, Ullmer C, Dumuis A, Bockaert J, Marin P (2002). "Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach". EMBO J. 21 (10): 2332–42. doi:10.1093/emboj/21.10.2332. PMC 126011 . PMID 12006486.
Hori K, Konno D, Maruoka H, Sobue K (2003). "MALS is a binding partner of IRSp53 at cell-cell contacts". FEBS Lett. 554 (1–2): 30–4. doi: 10.1016/S0014-5793(03)01074-3 . PMID 14596909. S2CID 30329043.
Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi: 10.1074/jbc.M400284200 . PMID 14960569.
Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi: 10.1074/jbc.M400285200 . PMID 15024025.
Petrosky KY, Ou HD, Löhr F, Dötsch V, Lim WA (2006). "A general model for preferential hetero-oligomerization of LIN-2/7 domains: mechanism underlying directed assembly of supramolecular signaling complexes". J. Biol. Chem. 280 (46): 38528–36. doi: 10.1074/jbc.M506536200 . PMID 16147993.
Mendes CC, Gomes DA, Thompson M, Souto NC, Goes TS, Goes AM, Rodrigues MA, Gomez MV, Nathanson MH, Leite MF (2006). "The type III inositol 1,4,5-trisphosphate receptor preferentially transmits apoptotic Ca2+ signals into mitochondria". J. Biol. Chem. 280 (49): 40892–900. doi: 10.1074/jbc.M506623200 . PMID 16192275.
Bohl J, Brimer N, Lyons C, Vande Pol SB (2007). "The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions". J. Biol. Chem. 282 (13): 9392–400. doi: 10.1074/jbc.M610002200 . PMID 17237226.
Onda T, Uzawa K, Nakashima D, Saito K, Iwadate Y, Seki N, Shibahara T, Tanzawa H (2007). "Lin-7C/VELI3/MALS-3: an essential component in metastasis of human squamous cell carcinoma" (PDF). Cancer Res. 67 (20): 9643–8. doi: 10.1158/0008-5472.CAN-07-1911 . hdl:10130/633. PMID 17942893.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000148943 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027162 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10341223-5] Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. doi: 10.1523/JNEUROSCI.19-11-04189.1999 . PMC 6782594 . PMID 10341223.

[entrez-6] "Entrez Gene: LIN7C lin-7 homolog C (C. elegans)".

[pmid14960569-7] 1 2 3 Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi: 10.1074/jbc.M400284200 . PMID 14960569.

[pmid15024025-8] 1 2 Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi: 10.1074/jbc.M400285200 . PMID 15024025.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

LIN7C

Contents

Interactions

Related Research Articles

References

Further reading