LINGO2

LINGO2
Identifiers
Aliases	LINGO2 , LERN3, LRRN6C, leucine rich repeat and Ig domain containing 2
External IDs	OMIM: 609793 MGI: 2442298 HomoloGene: 17621 GeneCards: LINGO2
Gene location (Human)
Chr.	Chromosome 9 (human)
End	28,670,286 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	36,951,747 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; endothelial cell; ; middle temporal gyrus; ; Brodmann area 23; ; myometrium; ; sperm; ; entorhinal cortex; ; islet of Langerhans; ; Brodmann area 46; ; cerebellar vermis;
	Top expressed in
	secondary oocyte; ; piriform cortex; ; respiratory epithelium; ; olfactory epithelium; ; superior frontal gyrus; ; ventromedial nucleus; ; primary motor cortex; ; cingulate gyrus; ; medial dorsal nucleus; ; superior colliculus;
	More reference expression data
	n/a
Orthologs
	158038
	242384
	ENSG00000174482
	ENSMUSG00000045083
	Q7L985
	Q3URE9
	NM_001258282 ; NM_152570 ; NM_001354574 ; NM_001354575
	NM_001165999 ; NM_001166000 ; NM_001166001 ; NM_175516
	NP_001245211 ; NP_689783 ; NP_001341503 ; NP_001341504
	NP_001159471 ; NP_001159472 ; NP_001159473 ; NP_780725
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 28, 2022

Leucine rich repeat and Ig domain containing 2 is a protein that in humans is encoded by the LINGO2 gene. ^[5]

Related Research Articles

NLR family pyrin domain containing 3 (NLRP3), is a protein that in humans is encoded by the NLRP3 gene located on the long arm of chromosome 1.

LRRTM1 is a brain-expressed imprinted gene that encodes a leucine-rich repeat transmembrane protein that interacts with neurexins and neuroligins to modulate synaptic cell adhesion in neurons. As the name implies, its protein product is a transmembrane protein that contains many leucine rich repeats. It is expressed during the development of specific forebrain structures and shows a variable pattern of maternal downregulation.

Leucine-rich repeat kinase 2 (LRRK2), also known as dardarin and PARK8, is a large, multifunctional kinase enzyme that in humans is encoded by the LRRK2 gene. LRRK2 is a member of the leucine-rich repeat kinase family. Variants of this gene are associated with an increased risk of Parkinson's disease and Crohn's disease.

Leucine-rich repeat-containing G-protein coupled receptor 4 is a protein that in humans is encoded by the LGR4 gene. LGR4 is known to have a role in the development of the male reproductive tract, eyelids, hair and bone.

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Prolargin is a protein that in humans is encoded by the PRELP gene.

Leucine-rich repeats and death domain containing, also known as LRDD or p53-induced protein with a death domain (PIDD), is a protein which in humans is encoded by the LRDD gene.

Leucine-rich repeat serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the LRRK1 gene.

F-box/LRR-repeat protein 7 is a protein that in humans is encoded by the FBXL7 gene.

Asporin is a protein that in humans is encoded by the ASPN gene.

Importin-11 is a protein that in humans is encoded by the IPO11 gene.

Leucine rich repeat and Immunoglobin-like domain-containing protein 1 also known as LINGO-1 is a protein which is encoded by the LINGO1 gene in humans. It belongs to the family of leucine-rich repeat proteins which are known for playing key roles in the biology of the central nervous system. LINGO-1 is a functional component of the Nogo receptor also known as the reticulon 4 receptor.

Leucine-rich repeat neuronal protein 2 is a protein that in humans is encoded by the LRRN2 gene.

Leucine-rich repeat and calponin homology domain-containing protein 4 is a protein that in humans is encoded by the LRCH4 gene.

Leucine-rich repeat-containing protein 50 is a protein that in humans is encoded by the LRRC50 gene.

Leucine-rich repeat neuronal protein 3, also known as neuronal leucine-rich repeat protein 3 (NLRR-3), is a protein that in humans is encoded by the LRRN3 gene.

F-box and leucine-rich repeat protein 4 is a protein that in humans is encoded by the FBXL4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000174482 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045083 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Leucine rich repeat and Ig domain containing 2" . Retrieved 2014-03-31.

Ferreira RC, Pan-Hammarström Q, Graham RR, Gateva V, Fontán G, Lee AT, et al. (September 2010). "Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency". Nature Genetics. 42 (9): 777–780. doi:10.1038/ng.644. PMID 20694011. S2CID 205356843.
Wu YW, Prakash KM, Rong TY, Li HH, Xiao Q, Tan LC, et al. (June 2011). "Lingo2 variants associated with essential tremor and Parkinson's disease". Human Genetics. 129 (6): 611–615. doi:10.1007/s00439-011-0955-3. PMID 21287203. S2CID 23493765.
Su FC, Chen CM, Chen YC, Wu YR (June 2012). "LINGO-2 polymorphism and the risk of Parkinson's disease in Taiwan". Parkinsonism & Related Disorders. 18 (5): 609–611. doi:10.1016/j.parkreldis.2011.11.013. PMID 22123311.
Ichikawa S, Koller DL, Padgett LR, Lai D, Hui SL, Peacock M, et al. (August 2010). "Replication of previous genome-wide association studies of bone mineral density in premenopausal American women". Journal of Bone and Mineral Research. 25 (8): 1821–1829. doi:10.1002/jbmr.62. PMC 3153352 . PMID 20200978.
Vilariño-Güell C, Wider C, Ross OA, Jasinska-Myga B, Kachergus J, Cobb SA, et al. (October 2010). "LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease". Neurogenetics. 11 (4): 401–408. doi:10.1007/s10048-010-0241-x. PMC 3930084 . PMID 20369371.
Carim-Todd L, Escarceller M, Estivill X, Sumoy L (December 2003). "LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex". The European Journal of Neuroscience. 18 (12): 3167–3182. doi:10.1111/j.1460-9568.2003.03003.x. PMID 14686891. S2CID 42086715.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000174482 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045083 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Leucine rich repeat and Ig domain containing 2" . Retrieved 2014-03-31.

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LINGO2

Related Research Articles

References

Further reading