LMO3

Last updated
LMO3
Identifiers
Aliases LMO3 , RBTN3, RBTNL2, RHOM3, Rhom-3, LIM domain only 3
External IDs OMIM: 180386 HomoloGene: 136507 GeneCards: LMO3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC) Chr 12: 16.55 – 16.61 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

LIM domain only protein 3 is a transcription co-factor, which in humans is encoded by the LMO3 gene. [3] [4] [5] LMO3 interacts with the tumor suppressor p53 and regulates its function. [6] LMO3 is considered to be an oncogene in Neuroblastoma. [7]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000048540 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A (February 2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications. 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID   19995558.
  4. Shi J, Cai W, Chen X, Ying K, Zhang K, Xie Y (August 2001). "Identification of dopamine responsive mRNAs in glial cells by suppression subtractive hybridization". Brain Research. 910 (1–2): 29–37. doi:10.1016/S0006-8993(01)02393-9. PMID   11489251. S2CID   43814085.
  5. EntrezGene 55885
  6. Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A (February 2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications. 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID   19995558.
  7. Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A (February 2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications. 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID   19995558.

Further reading