LNX1

LNX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3B76
Identifiers
Aliases	LNX1 , LNX, MPDZ, PDZRN2, ligand of numb-protein X 1
External IDs	OMIM: 609732; MGI: 1278335; HomoloGene: 7819; GeneCards: LNX1; OMA:LNX1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q12 Start 53,459,301 bp [1] End 53,701,405 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 C3.3 Start 74,753,108 bp [2] End 74,863,573 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus parotid gland Brodmann area 23 endothelial cell Brodmann area 46 oral cavity amniotic fluid skin of arm superior frontal gyrus jejunal mucosa Top expressed in motor neuron facial motor nucleus substantia nigra vestibular membrane of cochlear duct Paneth cell right ventricle epithelium of stomach lacrimal gland transitional epithelium of urinary bladder anterior horn of spinal cord More reference expression data BioGPS n/a
Gene ontology Molecular function PDZ domain binding protein binding metal ion binding ubiquitin-protein transferase activity transferase activity zinc ion binding Cellular component cytoplasm Biological process protein homooligomerization protein ubiquitination ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84708 16924 Ensembl ENSG00000072201 ENSMUSG00000029228 UniProt Q8TBB1 O70263 RefSeq (mRNA) NM_001126328 NM_032622 NM_001159577 NM_001159578 NM_001159579 NM_001159580 NM_010727 NM_001359074 RefSeq (protein) NP_001119800 NP_116011 NP_001153049 NP_001153050 NP_001153051 NP_001153052 NP_034857 NP_001346003 Location (UCSC) Chr 4: 53.46 – 53.7 Mb Chr 5: 74.75 – 74.86 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase LNX is an enzyme that in humans is encoded by the LNX1 gene. ^{[5] [6] [7]}

Interactions

LNX1 has been shown to interact with NAGK, ^[8] NUMB ^[6] and PAFAH1B3. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000072201 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029228 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Xie Y, Zhao W, Wang W, Zhao S, Tang R, Ying K, Zhou Z, Mao Y (Apr 2001). "Identification of a human LNX protein containing multiple PDZ domains". Biochemical Genetics. 39 (3–4): 117–26. doi:10.1023/A:1010269908398. PMID   11521506. S2CID   9150813.
6. Nie J, McGill MA, Dermer M, Dho SE, Wolting CD, McGlade CJ (Jan 2002). "LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation". The EMBO Journal. 21 (1–2): 93–102. doi:10.1093/emboj/21.1.93. PMC   125803 . PMID   11782429.
7. "Entrez Gene: LNX1 ligand of numb-protein X 1".
8. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

Further reading

• Dho SE, Jacob S, Wolting CD, French MB, Rohrschneider LR, McGlade CJ (Apr 1998). "The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX". The Journal of Biological Chemistry. 273 (15): 9179–87. doi: 10.1074/jbc.273.15.9179 . PMID   9535908.
• Rice DS, Northcutt GM, Kurschner C (Nov 2001). "The Lnx family proteins function as molecular scaffolds for Numb family proteins". Molecular and Cellular Neurosciences. 18 (5): 525–40. doi:10.1006/mcne.2001.1024. PMID   11922143. S2CID   6021682.
• Sollerbrant K, Raschperger E, Mirza M, Engstrom U, Philipson L, Ljungdahl PO, Pettersson RF (Feb 2003). "The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX)". The Journal of Biological Chemistry. 278 (9): 7439–44. doi: 10.1074/jbc.M205927200 . PMID   12468544.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Katoh M, Katoh M (Apr 2004). "Identification and characterization of PDZRN3 and PDZRN4 genes in silico". International Journal of Molecular Medicine. 13 (4): 607–13. doi:10.3892/ijmm.13.4.607. PMID   15010864.
• Armbruester V, Sauter M, Roemer K, Best B, Hahn S, Nty A, Schmid A, Philipp S, Mueller A, Mueller-Lantzsch N (Oct 2004). "Np9 protein of human endogenous retrovirus K interacts with ligand of numb protein X". Journal of Virology. 78 (19): 10310–9. doi:10.1128/JVI.78.19.10310-10319.2004. PMC   516385 . PMID   15367597.
• Chen J, Xu J, Zhao W, Hu G, Cheng H, Kang Y, Xie Y, Lu Y (Nov 2005). "Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas". The International Journal of Biochemistry & Cell Biology. 37 (11): 2273–83. doi:10.1016/j.biocel.2005.02.028. PMID   16002321.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.
• Weiss A, Baumgartner M, Radziwill G, Dennler J, Moelling K (Oct 2007). "c-Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand-of-Numb protein X1". FEBS Letters. 581 (26): 5131–6. doi: 10.1016/j.febslet.2007.09.062 . PMID   17936276. S2CID   43098921.