PAFAH1B3

PAFAH1B3
Identifiers
Aliases	PAFAH1B3 , PAFAHG, platelet activating factor acetylhydrolase 1b catalytic subunit 3
External IDs	OMIM: 603074; MGI: 108414; HomoloGene: 1933; GeneCards: PAFAH1B3; OMA:PAFAH1B3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.2 Start 42,297,033 bp [1] End 42,303,546 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 A3 Start 24,994,474 bp [2] End 24,997,411 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone gonad right hemisphere of cerebellum mucosa of transverse colon nucleus accumbens testicle prefrontal cortex right adrenal gland amygdala Top expressed in medial ganglionic eminence neural tube ventricular zone maxillary prominence mandibular prominence human fetus efferent ductule hand abdominal wall migratory enteric neural crest cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function 1-alkyl-2-acetylglycerophosphocholine esterase activity platelet-activating factor acetyltransferase activity protein binding hydrolase activity identical protein binding protein heterodimerization activity phospholipase A2 activity Cellular component cytoplasm extracellular exosome membrane cytosol Biological process lipid catabolic process brain development spermatogenesis nervous system development lipid metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5050 18476 Ensembl ENSG00000079462 ENSMUSG00000005447 UniProt Q15102 Q61205 RefSeq (mRNA) NM_002573 NM_001145939 NM_001145940 NM_008776 NM_001357350 RefSeq (protein) NP_001139411 NP_001139412 NP_002564 NP_032802 NP_001344279 Location (UCSC) Chr 19: 42.3 – 42.3 Mb Chr 7: 24.99 – 25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Platelet-activating factor acetylhydrolase IB subunit gamma is an enzyme that in humans is encoded by the PAFAH1B3 gene. ^{[5] [6]}

Interactions

PAFAH1B3 has been shown to interact with PAFAH1B1 ^[7] and LNX1. ^[8]

See also

• PAFAH1B1
• PAFAH1B2

References

1. GRCh38: Ensembl release 89: ENSG00000079462 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005447 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Adachi H, Tsujimoto M, Hattori M, Arai H, Inoue K (Sep 1995). "cDNA cloning of human cytosolic platelet-activating factor acetylhydrolase gamma-subunit and its mRNA expression in human tissues". Biochemical and Biophysical Research Communications. 214 (1): 180–7. doi:10.1006/bbrc.1995.2272. PMID   7669037.
6. "Entrez Gene: PAFAH1B3 platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa".
7. Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G (Apr 2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development". Mechanisms of Development. 92 (2): 263–71. doi:10.1016/S0925-4773(00)00242-2. PMID   10727864. S2CID   2447495.
8. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

Further reading

• Moro F, Arrigo G, Fogli A, Bernard L, Carrozzo R (Jul 1998). "The beta and gamma subunits of the human platelet-activating factor acetyl hydrolase isoform Ib (PAFAH1B2 and PAFAH1B3) map to chromosome 11q23 and 19q13.1, respectively". Genomics. 51 (1): 157–9. doi:10.1006/geno.1998.5322. PMID   9693049.
• Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G (Apr 2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development". Mechanisms of Development. 92 (2): 263–71. doi:10.1016/S0925-4773(00)00242-2. PMID   10727864. S2CID   2447495.
• Sheffield PJ, McMullen TW, Li J, Ho YS, Garrard SM, Derewenda U, Derewenda ZS (Jul 2001). "Preparation and crystal structure of the recombinant alpha(1)/alpha(2) catalytic heterodimer of bovine brain platelet-activating factor acetylhydrolase Ib". Protein Engineering. 14 (7): 513–9. doi: 10.1093/protein/14.7.513 . PMID   11522926.
• Saito Y, Doi K, Yamagishi N, Ishihara K, Hatayama T (Feb 2004). "Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems". Biochemical and Biophysical Research Communications. 314 (2): 396–402. doi:10.1016/j.bbrc.2003.12.108. PMID   14733918.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY (Dec 2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical Research Communications. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID   16236267.