PAFAH1B3

PAFAH1B3
Identifiers
Aliases	PAFAH1B3 , PAFAHG, platelet activating factor acetylhydrolase 1b catalytic subunit 3
External IDs	OMIM: 603074 MGI: 108414 HomoloGene: 1933 GeneCards: PAFAH1B3
Gene location (Human)
Chr.	Chromosome 19 (human)
End	42,303,546 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	24,997,411 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; nucleus accumbens; ; prefrontal cortex; ; Right adrenal gland; ; amygdala; ; Brodmann area 9; ; caudate nucleus; ; cingulate gyrus; ; hypothalamus; ; putamen;
	Top expressed in
	medial ganglionic eminence; ; neural tube; ; maxillary prominence; ; hand; ; abdominal wall; ; mirror; ; trigeminal ganglion; ; endocardial cushion; ; dermis; ; stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	1-alkyl-2-acetylglycerophosphocholine esterase activity ; platelet-activating factor acetyltransferase activity ; protein binding ; hydrolase activity ; identical protein binding ; protein heterodimerization activity ; phospholipase A2 activity ;
Cellular component	cytoplasm ; extracellular exosome ; membrane ; cytosol ;
Biological process	lipid catabolic process ; brain development ; spermatogenesis ; nervous system development ; lipid metabolism ;
	Sources:Amigo / QuickGO
Orthologs
	5050
	18476
	ENSG00000079462
	ENSMUSG00000005447
	Q15102
	Q61205
	NM_002573 ; NM_001145939 ; NM_001145940
	NM_008776 ; NM_001357350
	NP_001139411 ; NP_001139412 ; NP_002564
	NP_032802 ; NP_001344279
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 30, 2022

Platelet-activating factor acetylhydrolase IB subunit gamma is an enzyme that in humans is encoded by the PAFAH1B3 gene.^[5]^[6]

Interactions

PAFAH1B3 has been shown to interact with PAFAH1B1 ^[7] and LNX1.^[8]

Related Research Articles

Platelet-activating factor acetylhydrolase IB subunit alpha is an enzyme that in humans is encoded by the PAFAH1B1 gene. The protein is often referred to as Lis1 and plays an important role in regulating the motor protein Dynein.

Gamma-aminobutyric acid (GABA) B receptor, 2 (GABA_B2) is a G-protein coupled receptor subunit encoded by the GABBR2 gene in humans.

Proteasome activator complex subunit 1 is a protein that in humans is encoded by the PSME1 gene.

Elongation factor 1-beta is a protein that in humans is encoded by the EEF1B2 gene.

Elongation factor 1-gamma is a protein that in humans is encoded by the EEF1G gene.

AP-3 complex subunit beta-1 is a protein that in humans is encoded by the AP3B1 gene.

Translation initiation factor eIF-2B subunit gamma is a protein that in humans is encoded by the EIF2B3 gene.

SUMO-activating enzyme subunit 1 is a protein that in humans is encoded by the SAE1 gene.

Splicing factor 3B subunit 4 is a protein that in humans is encoded by the SF3B4 gene.

Coatomer subunit gamma-2 is a protein that in humans is encoded by the COPG2 gene.

G protein pathway suppressor 2 is a protein that in humans is encoded by the GPS2 gene.

Eukaryotic translation initiation factor 3 subunit G (eIF3g) is a protein that in humans is encoded by the EIF3G gene.

Four and a half LIM domains protein 3 is a protein that in humans is encoded by the FHL3 gene.

Regulator of G-protein signaling 10 is a protein that in humans is encoded by the RGS10 gene.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 is a protein that in humans is encoded by the GNG11 gene.

Platelet-activating factor acetylhydrolase IB subunit beta is an enzyme that in humans is encoded by the PAFAH1B2 gene.

Fibrinogen-like protein 1 (FGL-1) is a protein that is structurally related to fibrinogen. In humans, FGL-1 is encoded by the FGL1 gene. Four splice variants exist for this gene.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 is a protein that in humans is encoded by the GNG7 gene.

Phosphoinositide 3-kinase regulatory subunit 5 is an enzyme that in humans is encoded by the PIK3R5 gene.

Lipoprotein-associated phospholipase A₂ (Lp-PLA₂) also known as platelet-activating factor acetylhydrolase (PAF-AH) is a phospholipase A₂ enzyme that in humans is encoded by the PLA2G7 gene. Lp-PLA₂ is a 45-kDa protein of 441 amino acids. It is one of several PAF acetylhydrolases.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000079462 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005447 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Adachi H, Tsujimoto M, Hattori M, Arai H, Inoue K (Sep 1995). "cDNA cloning of human cytosolic platelet-activating factor acetylhydrolase gamma-subunit and its mRNA expression in human tissues". Biochemical and Biophysical Research Communications. 214 (1): 180–7. doi:10.1006/bbrc.1995.2272. PMID 7669037.
↑ "Entrez Gene: PAFAH1B3 platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa".
↑ Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G (Apr 2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development". Mechanisms of Development. 92 (2): 263–71. doi: 10.1016/S0925-4773(00)00242-2 . PMID 10727864. S2CID 2447495.
↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Moro F, Arrigo G, Fogli A, Bernard L, Carrozzo R (Jul 1998). "The beta and gamma subunits of the human platelet-activating factor acetyl hydrolase isoform Ib (PAFAH1B2 and PAFAH1B3) map to chromosome 11q23 and 19q13.1, respectively". Genomics. 51 (1): 157–9. doi:10.1006/geno.1998.5322. PMID 9693049.
Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G (Apr 2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development". Mechanisms of Development. 92 (2): 263–71. doi: 10.1016/S0925-4773(00)00242-2 . PMID 10727864. S2CID 2447495.
Sheffield PJ, McMullen TW, Li J, Ho YS, Garrard SM, Derewenda U, Derewenda ZS (Jul 2001). "Preparation and crystal structure of the recombinant alpha(1)/alpha(2) catalytic heterodimer of bovine brain platelet-activating factor acetylhydrolase Ib". Protein Engineering. 14 (7): 513–9. doi: 10.1093/protein/14.7.513 . PMID 11522926.
Saito Y, Doi K, Yamagishi N, Ishihara K, Hatayama T (Feb 2004). "Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems". Biochemical and Biophysical Research Communications. 314 (2): 396–402. doi:10.1016/j.bbrc.2003.12.108. PMID 14733918.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID 16169070. S2CID 8235923.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY (Dec 2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical Research Communications. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000079462 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005447 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7669037-5] Adachi H, Tsujimoto M, Hattori M, Arai H, Inoue K (Sep 1995). "cDNA cloning of human cytosolic platelet-activating factor acetylhydrolase gamma-subunit and its mRNA expression in human tissues". Biochemical and Biophysical Research Communications. 214 (1): 180–7. doi:10.1006/bbrc.1995.2272. PMID 7669037.

[entrez-6] "Entrez Gene: PAFAH1B3 platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa".

[pmid10727864-7] Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G (Apr 2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development". Mechanisms of Development. 92 (2): 263–71. doi: 10.1016/S0925-4773(00)00242-2 . PMID 10727864. S2CID 2447495.

[pmid16189514-8] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

PAFAH1B3

Contents

Interactions

See also

Related Research Articles

References

Further reading