PAFAH1B2

PAFAH1B2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1VYH
Identifiers
Aliases	PAFAH1B2 , HEL-S-303, platelet activating factor acetylhydrolase 1b catalytic subunit 2
External IDs	OMIM: 602508; MGI: 108415; HomoloGene: 1932; GeneCards: PAFAH1B2; OMA:PAFAH1B2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q23.3 Start 117,144,284 bp [1] End 117,176,894 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 A5.2 Start 45,962,859 bp [2] End 46,012,690 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte pons inferior ganglion of vagus nerve superior vestibular nucleus trigeminal ganglion pars reticulata subthalamic nucleus pars compacta middle temporal gyrus lateral nuclear group of thalamus Top expressed in spermatid spermatocyte tail of embryo renal corpuscle genital tubercle mandibular prominence neural tube central gray substance of midbrain somite maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function 1-alkyl-2-acetylglycerophosphocholine esterase activity platelet-activating factor acetyltransferase activity hydrolase activity protein homodimerization activity protein heterodimerization activity phospholipase A2 activity protein binding Cellular component plasma membrane nucleolus extracellular exosome fibrillar center extracellular region cytoplasm cytosol secretory granule lumen ficolin-1-rich granule lumen Biological process lipid catabolic process positive regulation of macroautophagy brain development spermatogenesis lipid metabolism neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5049 18475 Ensembl ENSG00000168092 ENSMUSG00000003131 UniProt P68402 Q61206 RefSeq (mRNA) NM_001184746 NM_001184747 NM_001184748 NM_001309431 NM_002572 NM_008775 RefSeq (protein) NP_001171675 NP_001171676 NP_001171677 NP_001296360 NP_002563 NP_032801 NP_001344167 NP_001344168 NP_001344169 NP_001344170 NP_001344172 NP_001344173 NP_001344174 NP_001344175 Location (UCSC) Chr 11: 117.14 – 117.18 Mb Chr 9: 45.96 – 46.01 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Platelet-activating factor acetylhydrolase IB subunit beta is an enzyme that in humans is encoded by the PAFAH1B2 gene. ^{[5] [6] [7]}

Interactions

PAFAH1B2 has been shown to interact with PAFAH1B1. ^[8]

See also

• PAFAH1B1
• PAFAH1B3

References

1. GRCh38: Ensembl release 89: ENSG00000168092 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003131 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Adachi H, Tsujimoto M, Hattori M, Arai H, Inoue K (Apr 1997). "Differential tissue distribution of the beta- and gamma-subunits of human cytosolic platelet-activating factor acetylhydrolase (isoform I)". Biochemical and Biophysical Research Communications. 233 (1): 10–3. doi:10.1006/bbrc.1997.6383. PMID   9144386.
6. Moro F, Arrigo G, Fogli A, Bernard L, Carrozzo R (Jul 1998). "The beta and gamma subunits of the human platelet-activating factor acetyl hydrolase isoform Ib (PAFAH1B2 and PAFAH1B3) map to chromosome 11q23 and 19q13.1, respectively". Genomics. 51 (1): 157–9. doi:10.1006/geno.1998.5322. PMID   9693049.
7. "Entrez Gene: PAFAH1B2 platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa".
8. Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G (Apr 2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development". Mechanisms of Development. 92 (2): 263–71. doi: 10.1016/S0925-4773(00)00242-2 . PMID   10727864.

Further reading

• Albrecht U, Abu-Issa R, Rätz B, Hattori M, Aoki J, Arai H, Inoue K, Eichele G (Dec 1996). "Platelet-activating factor acetylhydrolase expression and activity suggest a link between neuronal migration and platelet-activating factor". Developmental Biology. 180 (2): 579–93. doi: 10.1006/dbio.1996.0330 . PMID   8954729.
• Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G (Apr 2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development". Mechanisms of Development. 92 (2): 263–71. doi: 10.1016/S0925-4773(00)00242-2 . PMID   10727864.
• Sheffield PJ, McMullen TW, Li J, Ho YS, Garrard SM, Derewenda U, Derewenda ZS (Jul 2001). "Preparation and crystal structure of the recombinant alpha(1)/alpha(2) catalytic heterodimer of bovine brain platelet-activating factor acetylhydrolase Ib". Protein Engineering. 14 (7): 513–9. doi: 10.1093/protein/14.7.513 . PMID   11522926.
• Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A (Apr 2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Molecular & Cellular Proteomics. 3 (4): 311–26. doi: 10.1074/mcp.M300127-MCP200 . PMID   14718574.
• Bruneel A, Labas V, Mailloux A, Sharma S, Royer N, Vinh J, Pernet P, Vaubourdolle M, Baudin B (Oct 2005). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID   16130169. S2CID   26007149.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi: 10.1016/j.cell.2005.08.029 . hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Hasstedt SJ, Scott BT, Rosendaal FR, Callas PW, Vossen CY, Long GL, Bovill EG (Sep 2007). "Exclusion of the alpha2 subunit of platelet-activating factor acetylhydrolase 1b (PAFAH1B2) as a prothrombotic gene in a protein C-deficient kindred and population-based case-control sample". Thrombosis and Haemostasis. 98 (3): 587–92. doi:10.1160/th07-02-0134. PMID   17849047. S2CID   7180897.