LRRK1

LRRK1
Identifiers
Aliases	LRRK1 , RIPK6, Roco1, leucine-rich repeat kinase 1, leucine rich repeat kinase 1, OSMD
External IDs	OMIM: 610986; MGI: 2142227; HomoloGene: 23464; GeneCards: LRRK1; OMA:LRRK1 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q26.3 Start 100,919,327 bp [1] End 101,078,257 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 C Start 65,876,660 bp [2] End 66,038,098 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node appendix transverse colon spleen monocyte mucosa of transverse colon minor salivary glands skin of leg rectum stromal cell of endometrium Top expressed in right lung lobe transitional epithelium of urinary bladder left lung medullary collecting duct left lung lobe endothelial cell of lymphatic vessel conjunctival fornix mesenteric lymph nodes stroma of bone marrow epithelium of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinase activity transferase activity nucleotide binding protein kinase activity GTP binding protein binding ATP binding metal ion binding identical protein binding protein serine/threonine kinase activity signal transducer activity Cellular component mitochondrion cytoplasm cytosol Biological process positive regulation of canonical Wnt signaling pathway osteoclast development negative regulation of peptidyl-tyrosine phosphorylation positive regulation of intracellular signal transduction bone resorption phosphorylation positive regulation of peptidyl-tyrosine phosphorylation intracellular signal transduction protein phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79705 233328 Ensembl ENSG00000154237 ENSMUSG00000015133 UniProt Q38SD2 Q3UHC2 RefSeq (mRNA) NM_024652 NM_001039843 NM_146191 RefSeq (protein) NP_078928 NP_666303 Location (UCSC) Chr 15: 100.92 – 101.08 Mb Chr 7: 65.88 – 66.04 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Leucine-rich repeat serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the LRRK1 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000154237 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015133 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (May 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi: 10.1093/dnares/8.2.85 . PMID   11347906.
6. Bosgraaf L, Van Haastert PJ (Dec 2003). "Roc, a Ras/GTPase domain in complex proteins" (PDF). Biochim Biophys Acta. 1643 (1–3): 5–10. doi:10.1016/j.bbamcr.2003.08.008. PMID   14654223. S2CID   45525061.
7. "Entrez Gene: LRRK1 leucine-rich repeat kinase 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Korr D, Toschi L, Donner P, et al. (2006). "LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain". Cell. Signal. 18 (6): 910–20. doi:10.1016/j.cellsig.2005.08.015. PMID   16243488.
• Zody MC, Garber M, Sharpe T, et al. (2006). "Analysis of the DNA sequence and duplication history of human chromosome 15". Nature. 440 (7084): 671–5. Bibcode:2006Natur.440..671Z. doi: 10.1038/nature04601 . PMID   16572171.
• Haugarvoll K, Toft M, Ross OA, et al. (2007). "Variants in the LRRK1 gene and susceptibility to Parkinson's disease in Norway". Neurosci. Lett. 416 (3): 299–301. doi:10.1016/j.neulet.2007.02.020. PMID   17324517. S2CID   10196943.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1) 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Greggio E, Lewis PA, van der Brug MP, et al. (2007). "Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1". J. Neurochem. 102 (1): 93–102. doi: 10.1111/j.1471-4159.2007.04523.x . PMID   17394548.