LRRN2

LRRN2
Identifiers
Aliases	LRRN2 , FIGLER7, GAC1, LRANK1, LRRN5, leucine rich repeat neuronal 2
External IDs	OMIM: 605492 MGI: 106037 HomoloGene: 21274 GeneCards: LRRN2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	204,685,738 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	132,867,743 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; Region I of hippocampus proper; ; Brodmann area 10; ; nucleus accumbens; ; anterior pituitary; ; cingulate gyrus; ; ganglionic eminence; ; Brodmann area 9; ; entorhinal cortex; ; orbitofrontal cortex;
	Top expressed in
	lateral geniculate nucleus; ; medial dorsal nucleus; ; dentate gyrus; ; subiculum; ; medial geniculate nucleus; ; ventromedial nucleus; ; dorsomedial hypothalamic nucleus; ; superior frontal gyrus; ; hippocampus proper; ; cerebellar vermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor activity ;
Cellular component	integral component of membrane ; membrane ; extracellular space ; extracellular matrix ;
Biological process	cell adhesion ; axonogenesis ; signal transduction ;
	Sources:Amigo / QuickGO
Orthologs
	10446
	16980
	ENSG00000170382
	ENSMUSG00000026443
	O75325
	Q6PHP6
	NM_006338 ; NM_201630
	NM_010732
	NP_006329 ; NP_963924
	NP_034862
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 12, 2022

Leucine-rich repeat neuronal protein 2 is a protein that in humans is encoded by the LRRN2 gene.^[5]^[6]

The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.^[6]

Related Research Articles

Leucine-rich repeat-containing G-protein coupled receptor 6 is a protein that in humans is encoded by the LGR6 gene. Along with the other G-protein coupled receptors LGR4 and LGR5, LGR6 is a Wnt signaling pathway mediator. LGR6 also acts as an epithelial stem cell marker in squamous cell carcinoma in mice in vivo.

EGF-containing fibulin-like extracellular matrix protein 1 is a protein that in humans is encoded by the EFEMP1 gene.

LUC7 like 3 pre-mRNA splicing factor (LUC7L3), also known as Cisplatin resistance-associated overexpressed protein, or CROP, is a human gene.

Required for meiotic nuclear division 5 homolog B , also known as RMND5B, is a protein which in humans is encoded by the RMND5B gene. It has a zinc finger domain and is highly conserved throughout many eukaryotic organisms.

Leucine-rich repeat-containing protein 4 is a protein that in humans is encoded by the LRRC4 gene.

F-box/LRR-repeat protein 5 is a protein that in humans is encoded by the FBXL5 gene.

Prolargin is a protein that in humans is encoded by the PRELP gene.

Leucine-rich repeats and death domain containing, also known as LRDD or p53-induced protein with a death domain (PIDD), is a protein which in humans is encoded by the LRDD gene.

Lethal(3)malignant brain tumor-like protein is a protein that in humans is encoded by the L3MBTL gene.

Leucine-rich repeat-containing protein 41 is a protein that in humans is encoded by the LRRC41 gene.

Beta-catenin-like protein 1 is a protein that in humans is encoded by the CTNNBL1 gene.

Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein also known as calcium-response factor (CaRF) is a protein that in humans is encoded by the ALS2CR8 gene.

E3 ubiquitin-protein ligase LRSAM1, previously known as Tsg101-associated ligase (Tal), is an enzyme that in humans is encoded by the LRSAM1 gene.

DnaJ homolog subfamily C member 10 is a protein that in humans is encoded by the DNAJC10 gene.

Leucine-rich repeat neuronal protein 1 is a protein that in humans is encoded by the LRRN1 gene.

Importin-11 is a protein that in humans is encoded by the IPO11 gene.

Leucine-rich repeat transmembrane protein FLRT3 is a protein that in humans is encoded by the FLRT3 gene.

Mannose-1-phosphate guanyltransferase beta is an enzyme that in humans is encoded by the GMPPB gene.

Leucine-rich repeat and calponin homology domain-containing protein 4 is a protein that in humans is encoded by the LRCH4 gene.

Leucine-rich repeat-containing protein 8C is a protein that in humans is encoded by the LRRC8C gene. Researchers have found out that this protein, along with the other LRRC8 proteins LRRC8A, LRRC8B, LRRC8D, and LRRC8E, is sometimes a subunit of the heteromer protein Volume-Regulated Anion Channel. Volume-Regulated Anion Channels (VRACs) are crucial to the regulation of cell size by transporting chloride ions and various organic osmolytes, such as taurine or glutamate, across the plasma membrane, and that is not the only function these channels have been linked to.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000170382 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026443 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Almeida A, Zhu XX, Vogt N, Tyagi R, Muleris M, Dutrillaux AM, Dutrillaux B, Ross D, Malfoy B, Hanash S (Aug 1998). "GAC1, a new member of the leucine-rich repeat superfamily on chromosome band 1q32.1, is amplified and overexpressed in malignant gliomas". Oncogene. 16 (23): 2997–3002. doi: 10.1038/sj.onc.1201828 . PMID 9662332.
1 2 "Entrez Gene: LRRN2 leucine rich repeat neuronal 2".

Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID 16710414.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Adams MD, Soares MB, Kerlavage AR, et al. (1993). "Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library". Nat. Genet. 4 (4): 373–80. doi:10.1038/ng0893-373. PMID 8401585. S2CID 12612300.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000170382 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026443 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9662332-5] Almeida A, Zhu XX, Vogt N, Tyagi R, Muleris M, Dutrillaux AM, Dutrillaux B, Ross D, Malfoy B, Hanash S (Aug 1998). "GAC1, a new member of the leucine-rich repeat superfamily on chromosome band 1q32.1, is amplified and overexpressed in malignant gliomas". Oncogene. 16 (23): 2997–3002. doi: 10.1038/sj.onc.1201828 . PMID 9662332.

[entrez-6] 1 2 "Entrez Gene: LRRN2 leucine rich repeat neuronal 2".

[1]

[2]

[3]

[4]

[5]

[6]

LRRN2

Related Research Articles

References

Further reading