LSU rRNA

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Large subunit ribosomal ribonucleic acid (LSU rRNA) is the largest of the two major RNA components of the ribosome. Associated with a number of ribosomal proteins, the LSU rRNA forms the large subunit of the ribosome. The LSU rRNA acts as a ribozyme, catalyzing peptide bond formation.

Contents

LSU rRNA
Identifiers
SymbolLSU
Rfam CL00112
Other data
PDB structures PDBe

Characteristics

Characteristics of the LSU rRNA for exemplary species.
TypeLSU rRNA sizeSpeciesLengthAccessionReference
Bacterial (Prokaryotic) 23S Escherichia coli2,905 ntNR_076322.1 [2]
Archaeal (Prokaryotic)23SHalobacterium salinarum2,906 ntNR_076247.1 [3]
Eukaryotic 5.8S & 28S Homo sapiens157 + 5,025 ntNR_145821.1; M11167.1 [4] [5]
Mitochondrial 16S Homo sapiens1,559 ntNC_012920.1 [6] [7]
Plastid23SArabidopsis thaliana2,810 ntNC_000932.1 [8]

Use in phylogenetics

LSU rRNA sequences are widely used for working out evolutionary relationships among organisms, since they are of ancient origin and are found in all known forms of life.

See also

References

  1. ↑ Doris, Stephen M.; Smith, Deborah R.; Beamesderfer, Julia N.; Raphael, Benjamin J.; Nathanson, Judith A.; Gerbi, Susan A. (October 2015). "Universal and domain-specific sequences in 23S–28S ribosomal RNA identified by computational phylogenetics". RNA. 21 (10): 1719–1730. doi: 10.1261/rna.051144.115 . PMC   4574749 . PMID   26283689.
  2. ↑ "Escherichia coli 23S ribosomal RNA". 3 February 2015.
  3. ↑ "Halobacterium salinarum 23S ribosomal RNA". 3 February 2015.
  4. ↑ "Homo sapiens RNA, 5.8S ribosomal N1 (RNA5-8SN1), ribosomal RNA". 3 July 2020.
  5. ↑ "Homo sapiens 28S ribosomal RNA (nuclear)". 10 November 1986.
  6. ↑ Homo sapiens mitochondrion, complete genome. "Revised Cambridge Reference Sequence (rCRS): accession NC_012920", National Center for Biotechnology Information . Retrieved on 20 February 2017.
  7. ↑ Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJ, Staden R, Young IG (April 1981). "Sequence and organization of the human mitochondrial genome". Nature. 290 (5806): 457–465. Bibcode:1981Natur.290..457A. doi:10.1038/290457a0. PMID   7219534.
  8. ↑ "Arabidopsis thaliana 23S ribosomal RNA (chloroplast)". 3 April 2023.
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