LUC7L3

LUC7L3
Identifiers
Aliases	LUC7L3 , CRA, CREAP-1, CROP, LUC7A, OA48-18, hLuc7A, LUC7 like 3 pre-mRNA splicing factor
External IDs	OMIM: 609434 MGI: 1914934 HomoloGene: 75056 GeneCards: LUC7L3
Gene location (Human)
Chr.	Chromosome 17 (human)
End	50,756,219 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	94,212,814 bp
RNA expression pattern
	Top expressed in
	pylorus; ; sural nerve; ; endothelial cell; ; cardia; ; tibia; ; cerebellar vermis; ; seminal vesicula; ; corpus callosum; ; inferior ganglion of vagus nerve; ; visceral pleura;
	Top expressed in
	medullary collecting duct; ; Paneth cell; ; renal corpuscle; ; ciliary body; ; retinal pigment epithelium; ; fossa; ; condyle; ; primitive streak; ; saccule; ; iris;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding ; protein binding ; mRNA binding ; RNA binding ;
Cellular component	U1 snRNP ; U2-type prespliceosome ; nucleus ; nucleoplasm ; nuclear speck ;
Biological process	mRNA processing ; mRNA splice site selection ; RNA splicing ;
	Sources:Amigo / QuickGO
Orthologs
	51747
	67684
	ENSG00000108848
	ENSMUSG00000020863
	O95232
	Q5SUF2
	NM_006107 ; NM_016424 ; NM_001330330
	NM_026313 ; NM_001361573 ; NM_001361574 ; NM_001361575
	NP_001317259 ; NP_006098 ; NP_057508
	NP_080589 ; NP_001348502 ; NP_001348503 ; NP_001348504
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 12, 2024

LUC7 like 3 pre-mRNA splicing factor (LUC7L3), also known as Cisplatin resistance-associated overexpressed protein, or CROP, is a human gene.^[5]

This gene encodes a cisplatin resistance-associated overexpressed protein (CROP). The N-terminal half of the CROP contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.^[5]

Related Research Articles

Splicing factor, arginine/serine-rich 2 is a protein that in humans is encoded by the SFRS2 gene. MDS-associated splicing factor SRSF2 affects the expression of Class III and Class IV isoforms and perturbs granulopoiesis and SRSF2 P95H promotes Class IV splicing by binding to key ESE sequences in CSF3R exon 17, and that SRSF2, when mutated, contributes to dysgranulopoiesis.

Serine/arginine-Rich Splicing Factor (SRSF) protein kinase-1 SRPK1 is an enzyme that in humans is encoded by the SRPK1 gene.

Splicing factor, arginine/serine-rich 3 is a protein that in humans is encoded by the SFRS3 gene.

Dual specificity protein kinase CLK1 is an enzyme that in humans is encoded by the CLK1 gene.

FUS-interacting serine-arginine-rich protein 1 is a protein that in humans is encoded by the SFRS13A gene.

Splicing factor, arginine/serine-rich 4 is a protein that in humans is encoded by the SFRS4 gene.

Pre-mRNA-processing factor 17 is a protein that in humans is encoded by the CDC40 gene.

Serine/threonine-protein kinase SRPK2 is an enzyme that in humans is encoded by the SRPK2 gene.

Fas-activated serine/threonine kinase is an enzyme that in humans is encoded by the FASTK gene.

Dual specificity protein kinase CLK3 is an enzyme that in humans is encoded by the CLK3 gene. The CLK3 gene encodes a serine/threonine type protein kinase with a non-conserved N-terminal domain. A long and short isoform result from alternative splicing and coexist in different tissues. Isoform phclk3/152 lacks the kinase domain.

Transportin-3 is a protein that in humans is encoded by the TNPO3 gene.

Splicing factor, arginine/serine-rich 12 is a protein that in humans is encoded by the SFRS12 gene.

Cyclin-L1 is a protein that in humans is encoded by the CCNL1 gene.

Cyclin-L2 is a protein that in humans is encoded by the CCNL2 gene. The protein encoded by this gene belongs to cyclin family.

Coiled-coil domain-containing protein 55 is a protein that in humans is encoded by the CCDC55 gene. It is now known as nuclear speckle splicing regulatory protein 1. The HGNC approved gene name is NSRP1.

U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 is a protein that in humans is encoded by the ZRSR2 gene.

Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene.

Putative splicing factor, arginine/serine-rich 14 is a protein that in humans is encoded by the SFRS14 gene.

Tudor and KH domain-containing protein is a protein that in humans is encoded by the TDRKH gene.

Serine/arginine-rich splicing factor 1 (SRSF1) also known as alternative splicing factor 1 (ASF1), pre-mRNA-splicing factor SF2 (SF2) or ASF1/SF2 is a protein that in humans is encoded by the SRSF1 gene. ASF/SF2 is an essential sequence specific splicing factor involved in pre-mRNA splicing. SRSF1 is the gene that codes for ASF/SF2 and is found on chromosome 17. The resulting splicing factor is a protein of approximately 33 kDa. ASF/SF2 is necessary for all splicing reactions to occur, and influences splice site selection in a concentration-dependent manner, resulting in alternative splicing. In addition to being involved in the splicing process, ASF/SF2 also mediates post-splicing activities, such as mRNA nuclear export and translation.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000108848 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020863 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: CROP cisplatin resistance-associated overexpressed protein".

External links

Human LUC7L3 genome location and LUC7L3 gene details page in the UCSC Genome Browser .

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Nishii Y, Morishima M, Kakehi Y, et al. (2000). "CROP/Luc7A, a novel serine/arginine-rich nuclear protein, isolated from cisplatin-resistant cell line". FEBS Lett. 465 (2–3): 153–6. doi: 10.1016/S0014-5793(99)01744-5 . PMID 10631324. S2CID 7918526.
Chin LS, Singh SK, Wang Q, Murray SF (2000). "Identification of okadaic-acid-induced genes by mRNA differential display in glioma cells". J. Biomed. Sci. 7 (2): 152–9. doi:10.1007/BF02256622. PMID 10754390.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Umehara H, Nishii Y, Morishima M, et al. (2003). "Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A". Biochem. Biophys. Res. Commun. 301 (2): 324–9. doi:10.1016/S0006-291X(02)03017-6. PMID 12565863.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi: 10.1016/j.cub.2004.07.051 . PMID 15324660.
Brown V, Brown RA, Ozinsky A, et al. (2006). "Binding specificity of Toll-like receptor cytoplasmic domains". Eur. J. Immunol. 36 (3): 742–53. doi:10.1002/eji.200535158. PMC 2762736 . PMID 16482509.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.
Puig O, Bragado-Nilsson E, Koski T, Séraphin B (2007). "The U1 snRNP-associated factor Luc7p affects 5' splice site selection in yeast and human". Nucleic Acids Res. 35 (17): 5874–85. doi:10.1093/nar/gkm505. PMC 2034479 . PMID 17726058.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000108848 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020863 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: CROP cisplatin resistance-associated overexpressed protein".

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LUC7L3

Contents

Related Research Articles

References

External links

Further reading