LYAR

LYAR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WJV
Identifiers
Aliases	LYAR , ZC2HC2, ZLy1 antibody reactive
External IDs	OMIM: 617684 MGI: 107470 HomoloGene: 41200 GeneCards: LYAR
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4p16.3 Start 4,267,701 bp [1] End 4,290,154 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5 B3|5 20.29 cM Start 38,377,814 bp [2] End 38,391,650 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte sperm monocyte pericardium lymph node spleen Achilles tendon appendix blood gastrocnemius muscle Top expressed in otic placode spermatid seminiferous tubule spermatocyte saccule primitive streak interventricular septum yolk sac Paneth cell morula More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding protein binding RNA binding DNA binding Cellular component nucleus nucleolus photoreceptor outer segment cytoplasm cell projection Biological process negative regulation of transcription by RNA polymerase II rRNA processing erythrocyte development positive regulation of phagocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55646 17089 Ensembl ENSG00000145220 ENSMUSG00000067367 UniProt Q9NX58 Q08288 RefSeq (mRNA) NM_001145725 NM_017816 NM_025281 RefSeq (protein) NP_001139197 NP_060286 NP_079557 Location (UCSC) Chr 4: 4.27 – 4.29 Mb Chr 5: 38.38 – 38.39 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cell growth-regulating nucleolar protein is a protein that in humans is encoded by the LYAR gene (Ly-1 antibody reactive clone). ^[5]

LYAR contains a zinc finger motif and three copies of nuclear localization signals. LYAR is mainly localized to the nucleoli. LYAR is present at high levels in early embryos and preferentially in the liver fetal thymus. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000145220 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000067367 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: LYAR hypothetical protein FLJ20425".
6. Su L, Hershberger RJ, Weissman IL (May 1993). "LYAR, a novel nucleolar protein with zinc finger DNA-binding motifs, is involved in cell growth regulation". Genes Dev. 7 (5): 735–48. doi: 10.1101/gad.7.5.735 . PMID   8491376.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC   133617 . PMID   12429849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID   16083285.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.