LYPLA1

LYPLA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FJ2
Identifiers
Aliases	LYPLA1 , APT-1, APT1, LPL-I, LPL1, hAPT1, lysophospholipase I, lysophospholipase 1
External IDs	OMIM: 605599 MGI: 1344588 HomoloGene: 100781 GeneCards: LYPLA1
Gene location (Human)
Chr.	Chromosome 8 (human)
End	54,102,017 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	4,918,633 bp
RNA expression pattern
	Top expressed in
	human penis; ; cavity of mouth; ; vulva; ; right ventricle; ; superior surface of tongue; ; biceps brachii; ; jejunal mucosa; ; renal medulla; ; retinal pigment epithelium; ; placenta;
	Top expressed in
	gallbladder; ; superior surface of tongue; ; intercostal muscle; ; jejunum; ; extensor digitorum longus muscle; ; plantaris muscle; ; ileum; ; kidney; ; duodenum; ; masseter muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	lysophospholipase activity ; hydrolase activity ; lipase activity ; palmitoyl-(protein) hydrolase activity ; carboxylic ester hydrolase activity ; protein binding ;
Cellular component	cytoplasm ; cytosol ; extracellular exosome ; mitochondrion ;
Biological process	protein depalmitoylation ; regulation of nitric-oxide synthase activity ; negative regulation of Golgi to plasma membrane protein transport ; fatty acid metabolic process ; lipid metabolism ; metabolism ;
	Sources:Amigo / QuickGO
Orthologs
	10434
	18777
	ENSG00000120992
	ENSMUSG00000025903
	O75608 ; Q6IAQ1
	P97823
NM_001279356 ; NM_001279357 ; NM_001279358 ; NM_001279359 ; NM_001279360 ;
	NM_006330
	NM_008866 ; NM_001355712
NP_001266285 ; NP_001266286 ; NP_001266287 ; NP_001266288 ; NP_001266289 ;
	NP_006321 ; NP_006321.1
	NP_032892 ; NP_001342641
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Acyl-protein thioesterase 1 is an enzyme that in humans is encoded by the LYPLA1 gene.^[5]^[6]

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine in both monomeric and micellar forms. The use of alternate polyadenylation sites has been found for this gene. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet.^[6]

Related Research Articles

Colipase, abbreviated CLPS, is a protein co-enzyme required for optimal enzyme activity of pancreatic lipase. It is secreted by the pancreas in an inactive form, procolipase, which is activated in the intestinal lumen by trypsin. Its function is to prevent the inhibitory effect of bile salts on the lipase-catalyzed intraduodenal hydrolysis of dietary long-chain triglycerides.

Bile salt-dependent lipase, also known as carboxyl ester lipase is an enzyme produced by the adult pancreas and aids in the digestion of fats. Bile salt-stimulated lipase is an equivalent enzyme found within breast milk. BSDL has been found in the pancreatic secretions of all species in which it has been looked for. BSSL, originally discovered in the milk of humans and various other primates, has since been found in the milk of many animals including dogs, cats, rats, and rabbits.

Ovarian cancer G-protein coupled receptor 1 is a protein that in humans is encoded by the GPR68 gene.

Probable G-protein coupled receptor 162 is a protein that in humans is encoded by the GPR162 gene.

Probable G-protein coupled receptor 85 is a protein that in humans is encoded by the GPR85 gene.

Peroxisomal acyl-coenzyme A oxidase 1 is an enzyme that in humans is encoded by the ACOX1 gene.

Phosducin-like protein is a protein that in humans is encoded by the PDCL gene.

40S ribosomal protein S13 is a protein that in humans is encoded by the RPS13 gene.

Acyl-coenzyme A thioesterase 8 is an enzyme that in humans is encoded by the ACOT8 gene.

Thiamin pyrophosphokinase 1 is an enzyme that in humans is encoded by the TPK1 gene.

40S ribosomal protein S17 is a protein that in humans is encoded by the RPS17 gene.

LYPLA3, also known as Group XV phospholipase A2, is an enzyme that in humans is encoded by the PLA2G15 gene.

Cytosolic acyl coenzyme A thioester hydrolase is an enzyme that in humans is encoded by the ACOT7 gene.

60S ribosomal protein L9 is a protein that in humans is encoded by the RPL9 gene.

Ras-related protein Rab-6C is a protein that in humans is encoded by the RAB6C gene.

Zinc finger protein 267 is a protein that in humans is encoded by the ZNF267 gene.

KN motif and ankyrin repeat domain-containing protein 1 is a protein that in humans is encoded by the KANK1 gene.

Spermatogenesis-associated protein 2 is a protein that in humans is encoded by the SPATA2 gene.

Acyl-coenzyme A thioesterase 12 or StAR-related lipid transfer protein 15 (STARD15) is an enzyme that in humans is encoded by the ACOT12 gene. The protein contains a StAR-related lipid transfer domain.

Dehydrodolichyl diphosphate synthase is an enzyme that in humans is encoded by the DHDDS gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000120992 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025903 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wang A, Yang HC, Friedman P, Johnson CA, Dennis EA (Apr 1999). "A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization". Biochim Biophys Acta. 1437 (2): 157–69. doi:10.1016/s1388-1981(99)00012-8. PMID 10064899.
1 2 "Entrez Gene: LYPLA1 lysophospholipase I".

Wang A, Dennis EA (1999). "Mammalian lysophospholipases". Biochim. Biophys. Acta. 1439 (1): 1–16. doi:10.1016/s1388-1981(99)00063-3. PMID 10395961.
Bohn E, Gerke V, Kresse H, et al. (1992). "Annexin II inhibits calcium-dependent phospholipase A1 and lysophospholipase but not triacyl glycerol lipase activities of rat liver hepatic lipase". FEBS Lett. 296 (3): 237–40. doi:10.1016/0014-5793(92)80294-Q. PMID 1531641. S2CID 19633878.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146 . PMID 9110174.
Wang A, Johnson CA, Jones Y, et al. (2000). "Subcellular localization and PKC-dependent regulation of the human lysophospholipase A/acyl-protein thioesterase in WISH cells". Biochim. Biophys. Acta. 1484 (2–3): 207–14. doi:10.1016/s1388-1981(00)00020-2. PMID 10760470. S2CID 24130546.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934 . PMID 11042152.
Devedjiev Y, Dauter Z, Kuznetsov SR, et al. (2001). "Crystal structure of the human acyl protein thioesterase I from a single X-ray data set to 1.5 A." Structure. 8 (11): 1137–46. doi: 10.1016/S0969-2126(00)00529-3 . PMID 11080636.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000120992 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025903 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10064899-5] Wang A, Yang HC, Friedman P, Johnson CA, Dennis EA (Apr 1999). "A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization". Biochim Biophys Acta. 1437 (2): 157–69. doi:10.1016/s1388-1981(99)00012-8. PMID 10064899.

[entrez-6] 1 2 "Entrez Gene: LYPLA1 lysophospholipase I".

[1]

[2]

[3]

[4]

[5]

[6]

LYPLA1

Related Research Articles

References

Further reading