LZTS1

Last updated

LZTS1
Identifiers
Aliases LZTS1 , F37, FEZ1, leucine zipper, putative tumor suppressor 1, leucine zipper tumor suppressor 1
External IDs OMIM: 606551; MGI: 2684762; HomoloGene: 10873; GeneCards: LZTS1; OMA:LZTS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021020
NM_001362884

NM_199364
NM_001370971

RefSeq (protein)

NP_066300
NP_001349813

NP_955396
NP_001357900

Location (UCSC) Chr 8: 20.25 – 20.3 Mb Chr 8: 69.59 – 69.64 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Leucine zipper putative tumor suppressor 1 is a protein that, in humans, is encoded by the LZTS1 gene. [5] [6] [7]

Contents

In melanocytic cells LZTS1 gene expression may be regulated by MITF. [8]

Interactions

LZTS1 has been shown to interact with EEF1G. [9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000061337 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036306 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ishii H, Baffa R, Numata SI, Murakumo Y, Rattan S, Inoue H, Mori M, Fidanza V, Alder H, Croce CM (May 1999). "The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors". Proc Natl Acad Sci U S A. 96 (7): 3928–33. Bibcode:1999PNAS...96.3928I. doi: 10.1073/pnas.96.7.3928 . PMC   22397 . PMID   10097140.
  6. Vecchione A, Baldassarre G, Ishii H, Nicoloso MS, Belletti B, Petrocca F, Zanesi N, Fong LY, Battista S, Guarnieri D, Baffa R, Alder H, Farber JL, Donovan PJ, Croce CM (Mar 2007). "Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development". Cancer Cell. 11 (3): 275–89. doi:10.1016/j.ccr.2007.01.014. PMC   1987708 . PMID   17349584.
  7. "Entrez Gene: LZTS1 leucine zipper, putative tumor suppressor 1".
  8. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi: 10.1111/j.1755-148X.2008.00505.x . PMID   19067971. S2CID   24698373.
  9. Ishii H, Vecchione A, Murakumo Y, Baldassarre G, Numata S, Trapasso F, Alder H, Baffa R, Croce CM (Aug 2001). "FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10374–9. Bibcode:2001PNAS...9810374I. doi: 10.1073/pnas.181222898 . PMC   56968 . PMID   11504921.

Further reading