LZTS1

LZTS1
Identifiers
Aliases	LZTS1 , F37, FEZ1, leucine zipper, putative tumor suppressor 1, leucine zipper tumor suppressor 1
External IDs	OMIM: 606551 MGI: 2684762 HomoloGene: 10873 GeneCards: LZTS1
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8p21.3 Start 20,246,165 bp [1] End 20,303,963 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 B3.3 Start 69,585,321 bp [2] End 69,636,877 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence nucleus accumbens Brodmann area 23 caudate nucleus amygdala prefrontal cortex putamen dorsolateral prefrontal cortex Brodmann area 9 endothelial cell Top expressed in olfactory tubercle piriform cortex Region I of hippocampus proper superior frontal gyrus nucleus accumbens primary motor cortex amygdala ganglionic eminence secondary oocyte prefrontal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity protein binding microtubule binding Cellular component cytoplasm postsynaptic membrane cell projection membrane postsynaptic density plasma membrane dendritic spine synapse cell junction apical plasma membrane neuron projection dendritic shaft cell body Biological process negative regulation of macroautophagy transcription, DNA-templated cell cycle regulation of transcription, DNA-templated mitotic cell cycle phase transition regulation of synaptic plasticity regulation of dendrite morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11178 211134 Ensembl ENSG00000061337 ENSMUSG00000036306 UniProt Q9Y250 P60853 RefSeq (mRNA) NM_021020 NM_001362884 NM_199364 NM_001370971 RefSeq (protein) NP_066300 NP_001349813 NP_955396 NP_001357900 Location (UCSC) Chr 8: 20.25 – 20.3 Mb Chr 8: 69.59 – 69.64 Mb PubMed search [3] [4]
Wikidata
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Leucine zipper putative tumor suppressor 1 is a protein that, in humans, is encoded by the LZTS1 gene. ^{[5] [6] [7]}

In melanocytic cells LZTS1 gene expression may be regulated by MITF. ^[8]

Interactions

LZTS1 has been shown to interact with EEF1G. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000061337 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036306 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishii H, Baffa R, Numata SI, Murakumo Y, Rattan S, Inoue H, Mori M, Fidanza V, Alder H, Croce CM (May 1999). "The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors". Proc Natl Acad Sci U S A. 96 (7): 3928–33. Bibcode:1999PNAS...96.3928I. doi: 10.1073/pnas.96.7.3928 . PMC   22397 . PMID   10097140.
6. Vecchione A, Baldassarre G, Ishii H, Nicoloso MS, Belletti B, Petrocca F, Zanesi N, Fong LY, Battista S, Guarnieri D, Baffa R, Alder H, Farber JL, Donovan PJ, Croce CM (Mar 2007). "Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development". Cancer Cell. 11 (3): 275–89. doi:10.1016/j.ccr.2007.01.014. PMC   1987708 . PMID   17349584.
7. "Entrez Gene: LZTS1 leucine zipper, putative tumor suppressor 1".
8. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi: 10.1111/j.1755-148X.2008.00505.x . PMID   19067971. S2CID   24698373.
9. Ishii H, Vecchione A, Murakumo Y, Baldassarre G, Numata S, Trapasso F, Alder H, Baffa R, Croce CM (Aug 2001). "FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10374–9. Bibcode:2001PNAS...9810374I. doi: 10.1073/pnas.181222898 . PMC   56968 . PMID   11504921.

Further reading

• Ono K, Uzawa K, Nakatsuru M, Shiiba M, Mochida Y, Tada A, Bukawa H, Miyakawa A, Yokoe H, Tanzawa H (2004). "Down-regulation of FEZ1/LZTS1 gene with frequent loss of heterozygosity in oral squamous cell carcinomas". Int. J. Oncol. 23 (2): 297–302. doi:10.3892/ijo.23.2.297. PMID   12851677.
• Hawkins GA, Mychaleckyj JC, Zheng SL, Faith DA, Kelly B, Isaacs SD, Wiley KE, Chang BL, Ewing CM, Bujnovszky P, Bleecker ER, Walsh PC, Meyers DA, Isaacs WB, Xu J (2002). "Germline sequence variants of the LZTS1 gene are associated with prostate cancer risk". Cancer Genet. Cytogenet. 137 (1): 1–7. doi:10.1016/S0165-4608(02)00549-6. PMID   12377406.
• Ishii H, Vecchione A, Murakumo Y, Baldassarre G, Numata S, Trapasso F, Alder H, Baffa R, Croce CM (2001). "FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10374–9. Bibcode:2001PNAS...9810374I. doi: 10.1073/pnas.181222898 . PMC   56968 . PMID   11504921.
• Cabeza-Arvelaiz Y, Sepulveda JL, Lebovitz RM, Thompson TC, Chinault AC (2001). "Functional identification of LZTS1 as a candidate prostate tumor suppressor gene on human chromosome 8p22". Oncogene. 20 (31): 4169–79. doi:10.1038/sj.onc.1204539. PMID   11464283. S2CID   38760860.