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Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels, formed in the earlier stage of vasculogenesis. Angiogenesis continues the growth of the vasculature mainly by processes of sprouting and splitting, but processes such as coalescent angiogenesis, vessel elongation and vessel cooption also play a role. Vasculogenesis is the embryonic formation of endothelial cells from mesoderm cell precursors, and from neovascularization, although discussions are not always precise. The first vessels in the developing embryo form through vasculogenesis, after which angiogenesis is responsible for most, if not all, blood vessel growth during development and in disease.
Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; the term is typically used when referring to metastasis by a cancerous tumor. The newly pathological sites, then, are metastases (mets). It is generally distinguished from cancer invasion, which is the direct extension and penetration by cancer cells into neighboring tissues.
The National Organization for the Professional Advancement of Black Chemists and Chemical Engineers or NOBCChE is a nonprofit, professional organization. NOBCChE's goal is to increase the number of minorities in science, technology, and engineering fields. The organization accomplishes this by creating bonds with professionals working at science-related companies and faculty at local school districts in order to get more minorities to pursue a career in science and engineering fields. NOBCChE focuses on establishing diversity programs for the professional development of young kids and to spread knowledge in science and engineering. NOBCChE chapters can be found nationwide.
Matrix metallopeptidase 9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), is a matrixin, a class of enzymes that belong to the zinc-metalloproteinases family involved in the degradation of the extracellular matrix. In humans the MMP9 gene encodes for a signal peptide, a propeptide, a catalytic domain with inserted three repeats of fibronectin type II domain followed by a C-terminal hemopexin-like domain.
72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene. The MMP2 gene is located on chromosome 16 at position 12.2.
Protein S100-A4 (S100A4) is a protein that in humans is encoded by the S100A4 gene.
Metastasis-associated protein MTA1 is a protein that in humans is encoded by the MTA1 gene. MTA1 is the founding member of the MTA family of genes. MTA1 is primarily localized in the nucleus but also found to be distributed in the extra-nuclear compartments. MTA1 is a component of several chromatin remodeling complexes including the nucleosome remodeling and deacetylation complex (NuRD). MTA1 regulates gene expression by functioning as a coregulator to integrate DNA-interacting factors to gene activity. MTA1 participates in physiological functions in the normal and cancer cells. MTA1 is one of the most upregulated proteins in human cancer and associates with cancer progression, aggressive phenotypes, and poor prognosis of cancer patients.
Protein NDRG1 is a protein that in humans is encoded by the NDRG1 gene.
RhoC is a small signaling G protein, and is a member of the Rac subfamily of the family Rho family of GTPases. It is encoded by the gene RHOC.
Lewis lung carcinoma is a tumor that spontaneously developed as an epidermoid carcinoma in the lung of a C57BL mouse. It was discovered in 1951 by Dr. Margaret Lewis of the Wistar Institute and became one of the first transplantable tumors.
Joan Massagué, is a Spanish biologist and the current director of the Sloan Kettering Institute at Memorial Sloan Kettering Cancer Center. He is also an internationally recognized leader in the study of both cancer metastasis and growth factors that regulate cell behavior, as well as a professor at the Weill Cornell Graduate School of Medical Sciences.
Gopal Chandra Kundu is an Indian cell and cancer biologist and a Senior Scientist (Scientist-G) at National Centre for Cell Science. He is known for his contributions towards the understanding the mechanism of cancer progression in breast, melanoma and other cancers and development of novel therapeutic targets and target-based therapy in cancers.
The tumor microenvironment (TME) is a complex ecosystem surrounding a tumor, composed of a variety of non-cancerous cells including blood vessels, immune cells, fibroblasts, signaling molecules and the extracellular matrix (ECM). Mutual interaction between cancer cells and the different components of the TME support its growth and invasion in healthy tissues which correlates with tumor resistance to current treatments and poor prognosis. Tumors can influence the microenvironment by releasing extracellular signals, promoting tumor angiogenesis and inducing peripheral immune tolerance, while the immune cells in the microenvironment can affect the growth and evolution of cancerous cells.
Axelopran is a drug which is under development by Theravance Biopharma and licensed to Glycyx for all indications. It acts as a peripherally acting μ-opioid receptor antagonist and also acts on κ-, and δ-opioid receptors, with similar affinity for the μ- and κ-opioid receptors and about an order of magnitude lower affinity for the δ-opioid receptor. Recent data suggests that μ-opioid antagonists have a direct effect on overall survival in patients with advanced cancer.
Sarah Spiegel is professor and chair of the Department of Biochemistry and Molecular Biology at Virginia Commonwealth University (VCU). In the mid-1990s she discovered the sphingosine-1-phosphate (S1P) molecule, a lipid which has been identified as a signaler for the spread of cancer, inflammation, and cardiovascular disease. Her research continues to focus on S1P.
Catherine D. Nobes is a Professor of Cell Biology and Head of School of Biochemistry at the University of Bristol. She studies the regulation of cell migration and invasion of cancer cells by Eph receptors.
Victoria Sanz Moreno is a Spanish scientist. She is professor of cancer cell and metastasis biology at The Institute of Cancer Research.
Ying E. Zhang is a Chinese-American biochemist specialized in TGF-beta signaling and functions of ubiquitin E3 ligase Smurfs to better understand cancer cells and metastasis. She is a senior investigator in the Laboratory of Cellular and Molecular Biology at the National Cancer Institute.
Denise Johnson Montell is an American biologist who is the Duggan Professor of Molecular, Cellular, and Developmental Biology at the University of California, Santa Barbara. Her research considers the oogenesis process in Drosophila and border cell migration. She has served as president of the Genetics Society of America and was elected to the National Academy of Sciences in 2021.
Gelareh Zadeh is an Iranian-Canadian physician who is a professor and the Wilkins Family Chair in the Department of Surgery at the University of Toronto. She is a neurosurgeon-scientist at Toronto Western Hospital. In 2020, Zadeh became the first woman to be elected Chair of the Division of Neurosurgery at the University of Toronto.
References
- 1 2 3 4 5 6 7 8 9 10 African American women chemists. Oxford University Press. 5 January 2012. pp. 74–83. ISBN 9780199742882.
- 1 2 3 4 5 6 7 8 9 10 11 "Linda C. Meade-Tollin". Science History Institute. 2009. Archived from the original on 14 February 2021. Retrieved 14 February 2021.
- ↑ "Oral history interview with Linda C. Meade-Tollin". Science History Institute Digital Collections. Retrieved 2022-01-19.
- ↑ "The Story of NOBCChE". National Organization for the Professional Advancement of Black Chemists and Chemical Engineers. Archived from the original on 16 February 2021. Retrieved 16 February 2021.