Lipophosphoglycan

Last updated February 23, 2025

Lipophosphoglycan (LPG) is a class of molecules found on the surface of some eukaryotes, in particular protozoa. Each is made up of two parts, lipid and polysaccharide (also called glycan). They are bonded by a phosphodiester, hence the name lipo-phospho-glycan.^[1]

One species with extensive lipophosphoglycan coating is Leishmania , a group of single-celled protozoan parasite which cause leishmaniasis in many mammals, including humans. Their coats help modulate their hosts' immunological responses.^[2] LPG-like substances are released into medium by the parasite and are called excreted factor in aggregate.^[2]

References

↑ Forestier, Claire-Lise; Gao, Qi; Boons, Geert-Jan (2014). "Leishmania lipophosphoglycan: how to establish structure-activity relationships for this highly complex and multifunctional glycoconjugate?". Frontiers in Cellular and Infection Microbiology. 4 (193): 193. doi: 10.3389/fcimb.2014.00193 . PMC 4301024 . PMID 25653924.
1 2 Turco, SJ; Descoteaux, A (1992). "The lipophosphoglycan of Leishmania parasites". Annual Review of Microbiology. 46: 65–94. doi:10.1146/annurev.mi.46.100192.000433. PMID 1444269.

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[1] Forestier, Claire-Lise; Gao, Qi; Boons, Geert-Jan (2014). "Leishmania lipophosphoglycan: how to establish structure-activity relationships for this highly complex and multifunctional glycoconjugate?". Frontiers in Cellular and Infection Microbiology. 4 (193): 193. doi: 10.3389/fcimb.2014.00193 . PMC 4301024 . PMID 25653924.

[TurcoDescoteaux1992-2] 1 2 Turco, SJ; Descoteaux, A (1992). "The lipophosphoglycan of Leishmania parasites". Annual Review of Microbiology. 46: 65–94. doi:10.1146/annurev.mi.46.100192.000433. PMID 1444269.

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