Leishmaniasis

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Leishmaniasis
Other namesLeishmaniosis
Skin ulcer due to leishmaniasis, hand of Central American adult 3MG0037 lores.jpg
Cutaneous leishmaniasis in the hand of a Central American adult
Pronunciation
Specialty Infectious disease
Symptoms Skin ulcers, fever, low red blood cells, enlarged liver [2] [3]
Causes Leishmania parasites spread by sandflies [2]
Prevention Bug nets, insecticide [2]
Frequency4–12 million [4] [5]
Deaths24,200 (2015) [6]

Leishmaniasis is a wide array of clinical manifestations caused by protozoal parasites of the Trypanosomatida genus Leishmania . [7] It is generally spread through the bite of phlebotomine sandflies, Phlebotomus and Lutzomyia , and occurs most frequently in the tropics and sub-tropics of Africa, Asia, the Americas, and southern Europe. [2] [8] The disease can present in three main ways: cutaneous, mucocutaneous, or visceral. [2] The cutaneous form presents with skin ulcers, while the mucocutaneous form presents with ulcers of the skin, mouth, and nose. The visceral form starts with skin ulcers and later presents with fever, low red blood cell count, and enlarged spleen and liver. [2] [3]

Contents

Infections in humans are caused by more than 20 species of Leishmania. [8] [2] Risk factors include poverty, malnutrition, deforestation, and urbanization. [2] All three types can be diagnosed by seeing the parasites under microscopy. [2] Additionally, visceral disease can be diagnosed by blood tests. [3]

Leishmaniasis can be partly prevented by sleeping under nets treated with insecticide. [2] Other measures include spraying insecticides to kill sandflies and treating people with the disease early to prevent further spread. [2] The treatment needed is determined by where the disease is acquired, the species of Leishmania, and the type of infection. [2] Some possible medications used for visceral disease include liposomal amphotericin B, [9] a combination of pentavalent antimonials and paromomycin, [9] and miltefosine. [10] For cutaneous disease, paromomycin, fluconazole, or pentamidine may be effective. [11]

About 4 to 12 million people are currently infected [4] [5] in some 98 countries. [3] About 2 million new cases [3] and between 20 and 50 thousand deaths occur each year. [2] [12] About 200 million people in Asia, Africa, South and Central America, and southern Europe live in areas where the disease is common. [3] [13] The World Health Organization has obtained discounts on some medications to treat the disease. [3] It is classified as a neglected tropical disease. [14] The disease may occur in a number of other animals, including dogs and rodents. [2]

Signs and symptoms

Cutaneous leishmaniasis ulcer Leishmaniasis ulcer.jpg
Cutaneous leishmaniasis ulcer

The symptoms of leishmaniasis are skin sores which erupt weeks to months after the person is bitten by infected sand flies.

Leishmaniasis may be divided into the following types: [15]

Leishmaniasis is considered one of the classic causes of a markedly enlarged (and therefore palpable) spleen; the organ, which is not normally felt during examination of the abdomen, may even become larger than the liver in severe cases.[ citation needed ]

Cause

Lifecycle of Leishmania Leishmaniasis life cycle diagram en.svg
Lifecycle of Leishmania

Leishmaniasis is transmitted by the bite of infected female phlebotomine sandflies [2] which can transmit the protozoa Leishmania . [2] (1) The sandflies inject the infective stage, metacyclic promastigotes, during blood meals. (2) Metacyclic promastigotes in the puncture wound are phagocytized by macrophages, and (3) transform into amastigotes. (4) Amastigotes multiply in infected cells and affect different tissues, depending in part on the host, and in part on which Leishmania species is involved. These differing tissue specificities cause the differing clinical manifestations of the various forms of leishmaniasis. (5,6) Sandflies become infected during blood meals on infected hosts when they ingest macrophages infected with amastigotes. (7) In the sandfly's midgut, the parasites differentiate into promastigotes, (8) which multiply, differentiate into metacyclic promastigotes, and migrate to the proboscis.

The genomes of three Leishmania species (L. major, L. infantum, and L. braziliensis) have been sequenced, and this has provided much information about the biology of the parasite. For example, in Leishmania, protein-coding genes are understood to be organized as large polycistronic units in a head-to-head or tail-to-tail manner; RNA polymerase  II transcribes long polycistronic messages in the absence of defined RNA pol II promoters, and Leishmania has unique features with respect to the regulation of gene expression in response to changes in the environment. The new knowledge from these studies may help identify new targets for urgently needed drugs and aid the development of vaccines. [16]

Vector

Although most of the literature mentions only one genus transmitting Leishmania to humans ( Lutzomyia ) in the New World, a 2003 study by Galati suggested a new classification for New World sand flies, elevating several subgenera to the genus level. Elsewhere in the world, the genus Phlebotomus is considered the vector of leishmaniasis. [16]

Possible non-human reservoirs

Some cases of infection of non-human animals of human-infecting species of Leishmania have been observed. In one study, L. major was identified in twelve out of ninety-one wild western lowland gorilla fecal samples [17] and in a study of fifty-two captive non-human primates under zoo captivity in a leishmaniasis endemic area, eight (all three chimpanzees, three golden lion tamarins, a tufted capuchin, and an Angolan talapoin), were found to be infected with L. infantum and capable of infecting Lutzomyia longipalpis sand flies, although "parasite loads in infected sand flies observed in this study were considered low". [18]

Organisms

Visceral disease is usually caused by Leishmania donovani , L. infantum, or L. chagasi, [3] but occasionally these species may cause other forms of disease. [3] The cutaneous form of the disease is caused by more than 15 species of Leishmania. [3]

Risk factors

Risk factors include malnutrition, deforestation, lack of sanitation, suppressed immune system and urbanization. [2]

Diagnosis

Bone marrow aspirate smear: visceral leishmaniasis Leishmania 2009-04-14 smear.JPG
Bone marrow aspirate smear: visceral leishmaniasis

Leishmaniasis is diagnosed in the hematology laboratory by direct visualization of the amastigotes (Leishman–Donovan bodies). Buffy-coat preparations of peripheral blood or aspirates from marrow, spleen, lymph nodes, or skin lesions should be spread on a slide to make a thin smear and stained with Leishman stain or Giemsa stain (pH 7.2) for 20 minutes. Amastigotes are seen within blood and spleen monocytes or, less commonly, in circulating neutrophils and in aspirated tissue macrophages. They are small, round bodies 2–4 μm in diameter with indistinct cytoplasm, a nucleus, and a small, rod-shaped kinetoplast. Occasionally, amastigotes may be seen lying free between cells. [19] However, the retrieval of tissue samples is often painful for the patient and identification of the infected cells can be difficult. So, other indirect immunological methods of diagnosis are developed, including enzyme-linked immunosorbent assay, antigen-coated dipsticks, and direct agglutination test. Although these tests are readily available, they are not the standard diagnostic tests due to their insufficient sensitivity and specificity[ citation needed ].

Several different polymerase chain reaction (PCR) tests are available for the detection of Leishmania DNA. [3] With this assay, a specific and sensitive diagnostic procedure is finally possible. The most sensitive PCR tests use minicircle kinetoplast DNA found in the parasite. Kinetoplast DNA contains sequences for mitochondrial proteins in its maxicircles(~25–50 per parasite), and guide RNA in its minicircles(~10'000 per parasite) of the kinetoplast. With this specific method, one can still detect Leishmania even with a very low parasite load. When needing to diagnose a specific species of Leishmania, as opposed to only detection, other PCR methods have been superior. [20]

Most forms of the disease are transmitted only from nonhuman animals, but some can be spread between humans. Infections in humans are caused by about 21 of 30 species that infect mammals; [21] the different species look the same, but they can be differentiated by isoenzyme analysis, DNA sequence analysis, or monoclonal antibodies.

Prevention

Treatment

Paromomycin is an inexpensive (US$10) and effective treatment for leishmaniasis. Paromomycin structure.svg
Paromomycin is an inexpensive (US$10) and effective treatment for leishmaniasis.

The treatment is determined by where the disease is acquired, the species of Leishmania, and the type of infection. [2] For visceral leishmaniasis in India, South America, and the Mediterranean, liposomal amphotericin B is the recommended treatment and is often used as a single dose. [3] [9] Rates of cure with a single dose of amphotericin have been reported as 95%. [3] In India, almost all infections are resistant to pentavalent antimonials. [3] In Africa, a combination of pentavalent antimonials and paromomycin is recommended. [9] These, however, can have significant side effects. [3] Miltefosine, an oral medication, is effective against both visceral and cutaneous leishmaniasis. [10] Side effects are generally mild, though it can cause birth defects if taken within three months of getting pregnant. [3] [10] It does not appear to work for L. major or L. braziliensis. [11]

The evidence around the treatment of cutaneous leishmaniasis is poor. [3] A number of topical treatments may be used for cutaneous leishmaniasis. Which treatments are effective depends on the strain, with topical paromomycin effective for L. major, L. tropica, L. mexicana, L. panamensis, and L. braziliensis. [11] Pentamidine is effective for L. guyanensis. [11] Oral fluconazole or itraconazole appears effective in L. major and L. tropica. [3] [11] There is limited evidence to support the use of heat therapy in cutaneous leishmaniasis as of 2015. [24]

There are no studies determining the effect of oral nutritional supplements on visceral leishmaniasis being treated with anti-leishmanial drug therapy. [25]

Epidemiology

Cutaneous leishmaniasis in North Africa; Leishmania infantum = green, Leishmania major = blue, Leishmania tropica = red Parasite130072-fig1 Map of cutaneous leishmaniasis in North Africa.tif
Cutaneous leishmaniasis in North Africa; Leishmania infantum = green, Leishmania major = blue, Leishmania tropica = red
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Disability-adjusted life year for leishmaniasis per 100,000 inhabitants.
  no data
  less than 20
  20–30
  30–40
  40–50
  50–60
  60–70
  70–80
  80–100
  100–120
  120–150
  150–200
  more than 200

Out of 200 countries and territories reporting to WHO, 97 countries and territories are endemic for leishmaniasis. [27] The settings in which leishmaniasis is found range from rainforests in Central and South America to deserts in western Asia and the Middle East. It affects as many as 12 million people worldwide, with 1.5–2.0 million new cases each year. [28] The visceral form of leishmaniasis has an estimated incidence of 500,000 new cases. [29] In 2014, more than 90% of new cases reported to WHO occurred in six countries: Brazil, Ethiopia, India, Somalia, South Sudan and Sudan. [30] As of 2010, it caused about 52,000 deaths, down from 87,000 in 1990. [12] Different types of the disease occur in different regions of the world. [2] Cutaneous disease is most common in Afghanistan, Algeria, Brazil, Colombia, and Iran, while mucocutaneous disease is most common in Bolivia, Brazil, and Peru, and visceral disease is most common in Bangladesh, Brazil, Ethiopia, India, and Sudan. [2]

Leishmaniasis is found through much of the Americas from northern Argentina to South Texas, though not in Uruguay or Chile, and has recently been shown to be spreading to North Texas and Oklahoma, [31] [32] and further expansion to the north may be facilitated by climate change as more habitat becomes suitable for vector and reservoir species for leishmaniasis. [33] Leishmaniasis is also known as papalomoyo, papa lo moyo,úlcera de los chicleros, and chiclera in Latin America. [34] During 2004, an estimated 3,400 troops from the Colombian army, operating in the jungles near the south of the country (in particular around the Meta and Guaviare departments), were infected with leishmaniasis. Allegedly, a contributing factor was that many of the affected soldiers did not use the officially provided insect repellent because of its disturbing odor. Nearly 13,000 cases of the disease were recorded in all of Colombia throughout 2004, and about 360 new instances of the disease among soldiers had been reported in February 2005. [35]

The disease is found across much of Asia, and in the Middle East. Within Afghanistan, leishmaniasis occurs commonly in Kabul, partly due to bad sanitation and waste left uncollected in streets, allowing parasite-spreading sand flies an environment they find favorable. [36] [37] In Kabul, the number of people infected was estimated to be at least 200,000, and in three other towns (Herat, Kandahar, and Mazar-i-Sharif) about 70,000 more occurred, according to WHO figures from 2002. [38] [39] Kabul is estimated as the largest center of cutaneous leishmaniasis in the world, with around 67,500 cases as of 2004. [40] Africa, in particular the East and North, [26] is also home to cases of leishmaniasis. Leishmaniasis is considered endemic also in some parts of southern parts of western Europe and spreading towards north in recent years. [41] For example, an outbreak of cutaneous and visceral leishmaniasis was reported from Madrid, Spain, between 2010 and 2012. [42]

Leishmaniasis is mostly a disease of the developing world, and is rarely known in the developed world outside a small number of cases, mostly in instances where troops are stationed away from their home countries. Leishmaniasis has been reported by U.S. troops stationed in Saudi Arabia and Iraq since the Gulf War of 1990, including visceral leishmaniasis. [43] [44] [45] In September 2005, the disease was contracted by at least four Dutch marines who were stationed in Mazar-i-Sharif, Afghanistan, and subsequently repatriated for treatment. [46] [47]

History

A 1917 case of cutaneous leishmaniasis in the Middle East, known then locally as "Jericho buttons" for the frequency of cases near the ancient city of Jericho JerichoButtons.jpg
A 1917 case of cutaneous leishmaniasis in the Middle East, known then locally as "Jericho buttons" for the frequency of cases near the ancient city of Jericho

Descriptions of conspicuous lesions similar to cutaneous leishmaniasis appear on tablets from King Ashurbanipal from the seventh century BCE, some of which may have derived from even earlier texts from 1500 to 2500 BCE. Persian physicians, including Avicenna in the 10th century CE, gave detailed descriptions of what was called balkh sore. [48] In 1756, Alexander Russell, after examining a Turkish patient, gave one of the most detailed clinical descriptions of the disease. Physicians in the Indian subcontinent would describe it as kala-azar (pronounced kālā āzār, the Urdu, Hindi, and Hindustani phrase for "black fever", kālā meaning black and āzār meaning fever or disease). In the Americas, evidence of the cutaneous form of the disease in Ecuador and Peru appears in pre-Inca pottery depicting skin lesions and deformed faces dating back to the first century CE. Some 15th- and 16th-century texts from the Inca period and from Spanish colonials mention "valley sickness", "Andean sickness", or "white leprosy", which are likely to be the cutaneous form. [49]

It remains unclear who first discovered the organism. David Douglas Cunningham, Surgeon Major of the British Indian army, may have seen it in 1885 without being able to relate it to the disease. [50] [51] Peter Borovsky, a Russian military surgeon working in Tashkent, conducted research into the etiology of "oriental sore", locally known as sart sore, and in 1898 published the first accurate description of the causative agent, correctly described the parasite's relation to host tissues and correctly referred it to the protozoa. However, because his results were published in Russian in a journal with low circulation, his results were not internationally acknowledged during his lifetime. [52] In 1901, William Boog Leishman identified certain organisms in smears taken from the spleen of a patient who had died from "dum-dum fever" (Dum Dum is an area close to Calcutta) and proposed them to be trypanosomes, found for the first time in India. [53] A few months later, Captain Charles Donovan (1863–1951) confirmed the finding of what became known as Leishman-Donovan bodies in smears taken from people in Madras in southern India. [54] But it was Ronald Ross who proposed that Leishman-Donovan bodies were the intracellular stages of a new parasite, which he named Leishmania donovani. [55] The link with the disease kala-azar was first suggested by Charles Donovan, and was conclusively demonstrated by Charles Bentley's discovery of L. donovani in patients with kala-azar. [56] Transmission by the sandfly was hypothesized by Lionel Napier and Ernest Struthers at the School of Tropical Medicine at Calcutta and later proven by his colleagues. [57] [58] The disease became a major problem for Allied troops fighting in Sicily during the Second World War; research by Leonard Goodwin then showed pentostam was an effective treatment. [59]

Society and culture

The Institute for OneWorld Health has reintroduced the drug paromomycin for treatment of leishmaniasis, results with which led to its approval as an orphan drug. The Drugs for Neglected Diseases Initiative is also actively facilitating the search for novel therapeutics. A treatment with paromomycin will cost about US$10. The drug had originally been identified in the 1950s, but had been abandoned because it would not be profitable, as the disease mostly affects poor people. [60] The Indian government approved paromomycin for sale in August 2006. [61]

By 2012 the World Health Organization had successfully negotiated with the manufacturers to achieve a reduced cost for liposomal amphotericin B, to US$18 a vial, but a number of vials are needed for treatment and it must be kept at a stable, cool temperature. [3]

Research

A parasitologist working on L. major in a biocontainment hood Leishmania culture in hood 2.jpg
A parasitologist working on L. major in a biocontainment hood

As of 2017, no leishmaniasis vaccine for humans was available. [62] [63] Research to produce a human vaccine is ongoing. [63]

Currently some effective leishmaniasis vaccines for dogs exist. [64] There is also consideration that public health practices can control or eliminate leishmaniasis without a vaccine. [63] Pyrimidine–based drugs are being explored as anti-leishmanial compounds. [65]

See also

Related Research Articles

<i>Leishmania</i> Genus of parasitic flagellate protist

Leishmania is a parasitic protozoan, a single-celled organism of the genus Leishmania that is responsible for the disease leishmaniasis. They are spread by sandflies of the genus Phlebotomus in the Old World, and of the genus Lutzomyia in the New World. At least 93 sandfly species are proven or probable vectors worldwide. Their primary hosts are vertebrates; Leishmania commonly infects hyraxes, canids, rodents, and humans.

<span class="mw-page-title-main">Sandfly</span> Name of several types of blood-sucking fly

Sandfly or sand fly is a colloquial name for any species or genus of flying, biting, blood-sucking dipteran (fly) encountered in sandy areas. In the United States, sandfly may refer to certain horse flies that are also known as "greenheads", or to members of the family Ceratopogonidae. The bites usually result in a small, intensely itchy bump or welt, the strength of which intensifies over a period of 5-7 days before dissipating. Moderate relief is achieved with varying success through the application of over the counter products such as Benadryl (ingested) or an analgesic cream such as After Bite. Outside the United States, sandfly may refer to members of the subfamily Phlebotominae within the Psychodidae. Biting midges (Ceratopogonidae) are sometimes called sandflies or no-see-ums. New Zealand sandflies are in the genus of sand fly Austrosimulium, a type of black fly.

<i>Lutzomyia</i> Genus of flies

Lutzomyia is a genus of phlebotomine sand flies consisting of nearly 400 species, at least 33 of which have medical importance as vectors of human disease. Species of the genus Lutzomyia are found only in the New World, distributed in southern areas of the Nearctic and throughout the Neotropical realm. Lutzomyia is one of the two genera of the subfamily Phlebotominae to transmit the Leishmania parasite, with the other being Phlebotomus, found only in the Old World. Lutzomyia sand flies also serve as vectors for the bacterial Carrion's disease and a number of arboviruses.

<i>Phlebotomus</i> Genus of flies

Phlebotomus is a genus of "sand flies" in the Diptera family Psychodidae. In the past, they have sometimes been considered to belong in a separate family, Phlebotomidae, but this alternative classification has not gained wide acceptance.

<span class="mw-page-title-main">Cutaneous leishmaniasis</span> Medical condition

Cutaneous leishmaniasis is the most common form of leishmaniasis affecting humans. It is a skin infection caused by a single-celled parasite that is transmitted by the bite of a phlebotomine sand fly. There are about thirty species of Leishmania that may cause cutaneous leishmaniasis.

<span class="mw-page-title-main">Visceral leishmaniasis</span> Human disease caused by protist parasites

Visceral leishmaniasis (VL), also known as kala-azar or "black fever", is the most severe form of leishmaniasis and, without proper diagnosis and treatment, is associated with high fatality. Leishmaniasis is a disease caused by protozoan parasites of the genus Leishmania.

<span class="mw-page-title-main">Miltefosine</span> Phospholipid drug

Miltefosine, sold under the trade name Impavido among others, is a medication mainly used to treat leishmaniasis and free-living amoeba infections such as Naegleria fowleri and Balamuthia mandrillaris. This includes the three forms of leishmaniasis: cutaneous, visceral and mucosal. It may be used with liposomal amphotericin B or paromomycin. It is taken by mouth.

A canine vector-borne disease (CVBD) is one of "a group of globally distributed and rapidly spreading illnesses that are caused by a range of pathogens transmitted by arthropods including ticks, fleas, mosquitoes and phlebotomine sandflies." CVBDs are important in the fields of veterinary medicine, animal welfare, and public health. Some CVBDs are of zoonotic concern.

<i>Leishmania infantum</i> Species of parasitic protist

Leishmania infantum is the causative agent of infantile visceral leishmaniasis in the Mediterranean region and in Latin America, where it has been called Leishmania chagasi. It is also an unusual cause of cutaneous leishmaniasis, which is normally caused by specific lineages. Wild canids and domestic dogs are the natural reservoir of this organism. The sandfly species Lutzomyia longipalpis serves as the primary vector for the transmission of the disease.

<i>Leishmania major</i> Species of parasitic protist

Leishmania major is a species of parasite found in the genus Leishmania, and is associated with the disease zoonotic cutaneous leishmaniasis. L. major is an intracellular pathogen which infects the macrophages and dendritic cells of the immune system. Though Leishmania species are found on every continent aside from Antarctica, Leishmania major is found only in the Eastern Hemisphere, specifically in Northern Africa, the Middle East, Northwestern China, and Northwestern India.

<span class="mw-page-title-main">Protozoan infection</span> Parasitic disease caused by a protozoan

Protozoan infections are parasitic diseases caused by organisms formerly classified in the kingdom Protozoa. These organisms are now classified in the supergroups Excavata, Amoebozoa, Harosa, and Archaeplastida. They are usually contracted by either an insect vector or by contact with an infected substance or surface.

<span class="mw-page-title-main">Canine leishmaniasis</span> Disease affecting dogs

Canine leishmaniasis (LEESH-ma-NIGH-ah-sis) is a zoonotic disease caused by Leishmania parasites transmitted by the bite of an infected phlebotomine sandfly. There have been no documented cases of leishmaniasis transmission from dogs to humans. Canine leishmaniasis was first identified in Europe in 1903, and in 1940, 40% of all dogs in Rome were determined to be positive for leishmaniasis. Traditionally thought of as a disease only found near the Mediterranean basin, 2008 research claims new findings are evidence that canine leishmaniasis is currently expanding in continental climate areas of northwestern Italy, far from the recognized disease-endemic areas along the Mediterranean coasts. Cases of leishmaniasis began appearing in North America in 2000, and, as of 2008, Leishmania-positive foxhounds have been reported in 22 U.S. states and two Canadian provinces.

<i>Leishmania donovani</i> Species of intracellular parasite

Leishmania donovani is a species of intracellular parasites belonging to the genus Leishmania, a group of haemoflagellate kinetoplastids that cause the disease leishmaniasis. It is a human blood parasite responsible for visceral leishmaniasis or kala-azar, the most severe form of leishmaniasis. It infects the mononuclear phagocyte system including spleen, liver and bone marrow. Infection is transmitted by species of sandfly belonging to the genus Phlebotomus in Old World and Lutzomyia in New World. The species complex it represents is prevalent throughout tropical and temperate regions including Africa, China, India, Nepal, southern Europe, Russia and South America. The species complex is responsible for thousands of deaths every year and has spread to 88 countries, with 350 million people at constant risk of infection and 0.5 million new cases in a year.

<i>Leishmania tropica</i> Species of protozoan parasite

Leishmania tropica is a flagellate parasite and the cause of anthroponotic cutaneous leishmaniasis in humans. This parasite is restricted to Afro-Eurasia and is a common cause of infection in Afghanistan, Iran, Syria, Yemen, Algeria, Morocco, and northern India.

Leishmania braziliensis is a Leishmania species found in South America. It is associated with leishmaniasis.

<i>Leishmania mexicana</i> Species of parasitic protist

Leishmania mexicana is a species of obligate intracellular parasites of the protozoan genus Leishmania. In Mexico and Central America, this parasite is the primary cause of cutaneous leishmaniasis.

<span class="mw-page-title-main">Post-kala-azar dermal leishmaniasis</span>

Post-kala-azar dermal leishmaniasis (PKDL) is a complication of visceral leishmaniasis (VL); it is characterised by a macular, maculopapular, and nodular rash in a patient who has recovered from VL and who is otherwise well. The rash usually starts around the mouth from where it spreads to other parts of the body depending on severity.

<i>Lutzomyia longipalpis</i> Species of fly

Lutzomyia longipalpis is a species complex of sandfly belonging to the family Psychodidae. This species is primarily present in Central and South America, but has also appeared in Mexico. There have been reports of L. longipalpis as far south as Argentina, as they are found in a wide variety of ecological conditions. Both males and females feed on sugars from plants and aphids, but only adult females feed on the blood of other mammals. The species has recently begun appearing in urban areas throughout Brazil, and serves as a key vessel for the propagation of the parasite Leishmania infantum. The presence of these flies appears to be strongly correlated to the presence of domestic chickens in Latin America. The first major urban outbreak of the lethal Visceral leishmanias epidemic was detected in Teresina, Piauí State in the early 1980s following a massive planting of acacias.

Kala azar in India refers to the special circumstances of the disease kala azar as it exists in India. Kala azar is a major health problem in India with an estimated 146,700 new cases per year as of 2012. In the disease a parasite causes sickness after migrating to internal organs such as the liver, spleen and bone marrow. If left untreated the disease almost always results in the death. Signs and symptoms include fever, weight loss, fatigue, anemia, and substantial swelling of the liver and spleen.

<span class="mw-page-title-main">Leishmaniasis vaccine</span> Vaccine against leishmaniasis

A Leishmaniasis vaccine is a vaccine which would prevent leishmaniasis. As of 2017, no vaccine for humans was available. Currently some effective leishmaniasis vaccines for dogs exist.

References

  1. ↑ "Leishmaniasis definition and meaning | Collins English Dictionary". Archived from the original on 24 December 2013. Retrieved 23 December 2013.
  2. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 "Leishmaniasis Fact sheet N°375". World Health Organization. January 2014. Archived from the original on 21 February 2014. Retrieved 17 February 2014.
  3. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 Barrett MP, Croft SL (2012). "Management of trypanosomiasis and leishmaniasis". British Medical Bulletin. 104 (1): 175–96. doi:10.1093/bmb/lds031. PMC   3530408 . PMID   23137768.
  4. 1 2 "Leishmaniasis Magnitude of the problem". World Health Organization. Archived from the original on 26 October 2013. Retrieved 17 February 2014.
  5. 1 2 Vos T, Allen C, Arora M, Barber RM, Bhutta ZA, Brown A, et al. (GBD 2015 Disease Injury Incidence Prevalence Collaborators) (October 2016). "Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1545–1602. doi:10.1016/S0140-6736(16)31678-6. PMC   5055577 . PMID   27733282.
  6. ↑ Wang H, Naghavi M, Allen C, Barber RM, Bhutta ZA, Carter A, et al. (GBD 2015 Mortality Causes of Death Collaborators) (October 2016). "Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1459–1544. doi:10.1016/s0140-6736(16)31012-1. PMC   5388903 . PMID   27733281.
  7. ↑ Roy M, Rawat A, Kaushik S, Jyoti A, Srivastava VK (1 August 2022). "Endogenous cysteine protease inhibitors in upmost pathogenic parasitic protozoa". Microbiological Research. 261: 127061. doi: 10.1016/j.micres.2022.127061 . ISSN   0944-5013. PMID   35605309. S2CID   248741177.
  8. 1 2 Rawat A, Roy M, Jyoti A, Kaushik S, Verma K, Srivastava VK (August 2021). "Cysteine proteases: Battling pathogenic parasitic protozoans with omnipresent enzymes". Microbiological Research. 249: 126784. doi: 10.1016/j.micres.2021.126784 . PMID   33989978. S2CID   234597200.
  9. 1 2 3 4 Sundar S, Chakravarty J (January 2013). "Leishmaniasis: an update of current pharmacotherapy". Expert Opinion on Pharmacotherapy. 14 (1): 53–63. doi:10.1517/14656566.2013.755515. PMID   23256501. S2CID   207479873.
  10. 1 2 3 Dorlo TP, Balasegaram M, Beijnen JH, de Vries PJ (November 2012). "Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis". The Journal of Antimicrobial Chemotherapy. 67 (11): 2576–97. doi: 10.1093/jac/dks275 . PMID   22833634.
  11. 1 2 3 4 5 Minodier P, Parola P (May 2007). "Cutaneous leishmaniasis treatment". Travel Medicine and Infectious Disease. 5 (3): 150–8. doi:10.1016/j.tmaid.2006.09.004. PMID   17448941.
  12. 1 2 Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. (December 2012). "Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010". Lancet. 380 (9859): 2095–128. doi:10.1016/S0140-6736(12)61728-0. hdl: 10536/DRO/DU:30050819 . PMC   10790329 . PMID   23245604. S2CID   1541253.
  13. ↑ Ejazi SA, Ali N (January 2013). "Developments in diagnosis and treatment of visceral leishmaniasis during the last decade and future prospects". Expert Review of Anti-Infective Therapy. 11 (1): 79–98. doi:10.1586/eri.12.148. PMID   23428104. S2CID   20508342.
  14. ↑ "Neglected Tropical Diseases". cdc.gov. 6 June 2011. Archived from the original on 4 December 2014. Retrieved 28 November 2014.
  15. ↑ James WD, Berger TG, Elston DM (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. pp. 422–428. ISBN   978-0-7216-2921-6.
  16. 1 2 Myler PJ, Fasel N (2008). Leishmania: After The Genome. Caister Academic Press. ISBN   978-1-904455-28-8. Archived from the original on 23 April 2008.[ page needed ]
  17. ↑ Hamad I, Forestier CL, Peeters M, Delaporte E, Raoult D, Bittar F (15 January 2015). "Wild Gorillas as a Potential Reservoir of Leishmania major". J. Infect. Dis. 211 (2): 267–273. doi:10.1093/infdis/jiu380. PMC   4342692 . PMID   25001460.
  18. ↑ Ayisa Rodrigues de Oliveira, Guilherme Rafael Gomide Pinheiro, Herlandes P. Tinoco, Maria Elvira Loyola, Carlyle Mendes Coelho, Edelberto Santos Dias, Érika Michalsky Monteiro, Fabiana de Oliveira Lara e Silva, Angela Tinoco Pessanha, Andreza Geisiane Maia Souza, Nathália Cristina Lima Pereira, Nelder F. Gontijo, Ricardo T. Fujiwara, Tatiane Alves da Paixão, Renato Lima Santos (17 April 2019). "Competence of non-human primates to transmit Leishmania infantum to the invertebrate vector Lutzomyia longipalpis". PLOS Neglected Tropical Diseases. 13 (4): e0007313. doi: 10.1371/journal.pntd.0007313 . PMC   6488095 . PMID   30995227.
  19. ↑ Dacie JV, Bain BJ, Bates I (2006). Dacie and Lewis practical hematology. Philadelphia: Churchill Livingstone/Elsevier. ISBN   978-0-443-06660-3.[ page needed ]
  20. ↑ Bensoussan E, Nasereddin A, Jonas F, Schnur LF, Jaffe CL (April 2006). "Comparison of PCR assays for diagnosis of cutaneous leishmaniasis". Journal of Clinical Microbiology. 44 (4): 1435–9. doi:10.1128/JCM.44.4.1435-1439.2006. PMC   1448629 . PMID   16597873.
  21. ↑ "Parasites – Leishmaniasis". Centers for Disease Control and Prevention. January 2013.
  22. 1 2 Prevention CC (19 February 2020). "CDC – Leishmaniasis – Prevention & Control". cdc.gov. Retrieved 26 June 2021.
  23. 1 2
  24. ↑ Von Stebut E (March 2015). "Leishmaniasis". Journal of the German Society of Dermatology. 13 (3): 191–200, quiz 201. doi:10.1111/ddg.12595. PMID   25721626. S2CID   221649492.
  25. ↑ Custodio E, López-Alcalde J, Herrero M, Bouza C, Jimenez C, Storcksdieck Genannt Bonsmann S, Mouratidou T, López-Cuadrado T, Benito A, Alvar J, et al. (Cochrane Infectious Diseases Group) (March 2018). "Nutritional supplements for patients being treated for active visceral leishmaniasis". The Cochrane Database of Systematic Reviews. 2018 (3): CD012261. doi:10.1002/14651858.CD012261.pub2. PMC   6494195 . PMID   29578237.
  26. 1 2 Aoun K, Bouratbine A (2014). "Cutaneous leishmaniasis in North Africa: a review". Parasite. 21: 14. doi:10.1051/parasite/2014014. PMC   3952656 . PMID   24626301. Open Access logo PLoS transparent.svg
  27. ↑ "Leishmaniasis: Situation and trends". WHO Global Health Observatory. Retrieved 30 May 2018.
  28. ↑ "Leishmaniasis: Magnitude of the problem". World Health Organization. Archived from the original on 26 October 2013.
  29. ↑ "Hope for tropical disease vaccine". BBC News. 23 April 2006. Archived from the original on 27 April 2006.
  30. ↑ "Epidemiological situation: Epidemiology". World Health Organization. Archived from the original on 30 June 2004. Retrieved 30 May 2018.
  31. ↑ "Dallas News: Rare, non-fatal skin disease found in N. Texans". Archived from the original on 27 December 2009. Retrieved 2 June 2015.
  32. ↑ Clarke CF, Bradley KK, Wright JH, Glowicz J (January 2013). "Case report: Emergence of autochthonous cutaneous leishmaniasis in northeastern Texas and southeastern Oklahoma". The American Journal of Tropical Medicine and Hygiene. 88 (1): 157–61. doi:10.4269/ajtmh.2012.11-0717. PMC   3541728 . PMID   23185078.
  33. ↑ González C, Wang O, Strutz SE, González-Salazar C, Sánchez-Cordero V, Sarkar S (January 2010). Galvani AP (ed.). "Climate change and risk of leishmaniasis in north america: predictions from ecological niche models of vector and reservoir species". PLOS Neglected Tropical Diseases. 4 (1): e585. doi: 10.1371/journal.pntd.0000585 . PMC   2799657 . PMID   20098495.
  34. ↑ "Papalomoyo" (PDF). Archived from the original (PDF) on 23 July 2011. Retrieved 16 August 2010.
  35. ↑ "Informes – Informe de Fronteras Febrero 2005". Servicio Jesuita a Refugiados. Archived from the original on 10 November 2005.
  36. ↑ "CENTRAL/S. ASIA – Kabul: A city in intensive care". Al Jazeera English. Archived from the original on 18 June 2007.
  37. ↑ Birsel R (7 May 2007). "Disfiguring skin disease plagues Afghanistan". e-Ariana. Reuters. Archived from the original on 10 December 2015. Retrieved 8 December 2015.
  38. ↑ Birsel R (28 June 2002). "Disfiguring epidemic hits 270,000 Afghans". e-Ariana. Reuters. Archived from the original on 10 December 2015. Retrieved 8 December 2015.
  39. ↑ "WHO Seeking Funds to Prevent Leishmaniasis Outbreak in Afghanistan". voanews. October 2009.
  40. ↑ "World Health Organization action in Afghanistan aims to control debilitating leishmaniasis". Archived from the original on 26 October 2010.
  41. ↑ Medlock JM, Hansford KM, Van Bortel W, Zeller H, Alten B (June 2014). "A summary of the evidence for the change in European distribution of phlebotomine sand flies (Diptera: Psychodidae) of public health importance". Journal of Vector Ecology. 39 (1): 72–7. doi: 10.1111/j.1948-7134.2014.12072.x . PMID   24820558. S2CID   20645170.
  42. ↑ Aguado M, Espinosa P, Romero-Maté A, Tardío JC, Córdoba S, Borbujo J (May 2013). "Outbreak of cutaneous leishmaniasis in Fuenlabrada, Madrid". Actas Dermo-Sifiliograficas. 104 (4): 334–42. doi: 10.1016/j.adengl.2013.03.005 . PMID   23567452.
  43. ↑ Kennedy K (30 March 2010). "VCS Advocacy in the News: VA May Designate 9 Infectious Diseases as Related to Gulf War". Veterans for Common Sense. Archived from the original on 13 February 2011. Retrieved 10 February 2011.
  44. ↑ "Business: Company's mesh will help troops beat 'Baghdad boils'". Archived from the original on 16 March 2005.
  45. ↑ "Archived copy" (PDF). Archived from the original (PDF) on 12 October 2007. Retrieved 17 September 2007.{{cite web}}: CS1 maint: archived copy as title (link)
  46. ↑ Bhatia S, Goli D (2016). Leishmaniasis: Biology, Control and New Approaches for Its Treatment. CRC Press. ISBN   9781315341897.
  47. ↑ van Thiel PP, Leenstra T, de Vries HJ, van der Sluis A, van Gool T, Krull AC, van Vugt M, de Vries PJ, Zeegelaar JE, Bart A, van der Meide WF, Schallig HD, Faber WR, Kager PA (December 2010). "Cutaneous leishmaniasis (Leishmania major infection) in Dutch troops deployed in northern Afghanistan: epidemiology, clinical aspects, and treatment". The American Journal of Tropical Medicine and Hygiene. 83 (6): 1295–300. doi:10.4269/ajtmh.2010.10-0143. PMC   2990047 . PMID   21118937.
  48. ↑ Cox FE (October 2002). "History of human parasitology". Clinical Microbiology Reviews. 15 (4). The Wellcome Trust: 595–612. doi:10.1128/CMR.15.4.595-612.2002. ISBN   978-1-869835-86-6. OCLC   35161690. PMC   126866 . PMID   12364371.
  49. ↑ "WHO: Leishmaniasis background information – a brief history of the disease". Archived from the original on 15 March 2014.
  50. ↑ Cunningham DD (1885). On the presence of peculiar parasitic organisms in the tissue of a specimen of Delhi boil. Scientific memoirs officers Medical Sanitary Departments Government India. Calcutta: Printed by the superintendent of government printing, India. pp. 21–31. OCLC   11826455.
  51. ↑ Cox FE (October 2002). "History of human parasitology". Clinical Microbiology Reviews. 15 (4): 595–612. doi:10.1128/CMR.15.4.595-612.2002. PMC   126866 . PMID   12364371.
  52. ↑ Hoare CA (1938). "Early discoveries regarding the parasite of oriental sore". Transactions of the Royal Society of Tropical Medicine and Hygiene. 32 (1): 67–92. doi:10.1016/S0035-9203(38)90097-5.
  53. ↑ Leishman WB (1903). "On the possibility of the occurrence of trypanomiasis in India". The British Medical Journal. 1 (2213): 1252–1254. doi:10.1136/bmj.1.2213.1252. PMC   2514706 .
  54. ↑ Donovan C (1903). "Memoranda: On the possibility of the occurrence of trypanomiasis in India". The British Medical Journal.
  55. ↑ Ross R (November 1903). "Further Notes on Leishman's Bodies". British Medical Journal. 2 (2239): 1401. doi:10.1136/bmj.2.2239.1401. PMC   2514909 . PMID   20761210.
  56. ↑ Bentley CA (24 December 1903). "Telegram to R. Ross". Ross Archives: 47/157.
  57. ↑ "Dr. L. Everard Napier". The Indian Medical Gazette. 78 (5): 252. May 1943. PMC   5158438 . PMID   29012190.
  58. ↑ Gewurtz MS (1 January 2017). "Transnationalism in Missionary Medicine: The Case of Kala-azar in China and India, 1909–1946". Social Sciences and Missions. 30 (1–2): 30–43. doi:10.1163/18748945-03001001. ISSN   1874-8945.
  59. ↑ "Leonard Goodwin – Telegraph". The Daily Telegraph. 14 January 2009. Archived from the original on 20 April 2009. Retrieved 18 January 2009.
  60. ↑ "A Small Charity Takes the Reins in Fighting a Neglected Disease". New York Times . 31 July 2006. Archived from the original on 20 December 2016.
  61. ↑ "Drug Program – Clinical Trial of Paromomycin". Institute for OneWorld Health. Archived from the original on 6 June 2010. Retrieved 10 February 2011.
  62. ↑ Srivastava S, Shankar P, Mishra J, Singh S (May 2016). "Possibilities and challenges for developing a successful vaccine for leishmaniasis". Parasites & Vectors. 9 (1): 277. doi: 10.1186/s13071-016-1553-y . PMC   4866332 . PMID   27175732.
  63. 1 2 3 Ghorbani M, Farhoudi R (2018). "Leishmaniasis in humans: drug or vaccine therapy?". Drug Design, Development and Therapy. 12: 25–40. doi: 10.2147/DDDT.S146521 . PMC   5743117 . PMID   29317800.
  64. ↑ Moafi M, Rezvan H, Sherkat R, Taleban R (2019). "Leishmania Vaccines Entered in Clinical Trials: A Review of Literature". International Journal of Preventive Medicine. 10: 95. doi: 10.4103/ijpvm.IJPVM_116_18 . PMC   6592111 . PMID   31360342.
  65. ↑ Ramesh D, Sarkar D, Joji A, Singh M, Mohanty AK, G Vijayakumar B, Chatterjee M, Sriram D, Muthuvel SK, Kannan T (April 2022). "First-in-class pyrido[2,3- d ]pyrimidine-2,4(1 H ,3 H )-diones against leishmaniasis and tuberculosis: Rationale, in vitro, ex vivo studies and mechanistic insights". Archiv der Pharmazie. 355 (4): 2100440. doi:10.1002/ardp.202100440. ISSN   0365-6233. PMID   35106845. S2CID   246474821.
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