Sand flies Temporal range: Barremian [1] –Recent | |
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Phlebotomus papatasi | |
Scientific classification | |
Domain: | Eukaryota |
Kingdom: | Animalia |
Phylum: | Arthropoda |
Class: | Insecta |
Order: | Diptera |
Family: | Psychodidae |
Subfamily: | Phlebotominae Rondani, 1840 |
The Phlebotominae are a subfamily of the family Psychodidae. In several countries, their common name is sandfly, but that name is also applied to other flies. The Phlebotominae include many genera of blood-feeding (hematophagous) flies, including the primary vectors of leishmaniasis, bartonellosis and pappataci fever. In the New World, leishmaniasis is spread by sand flies in the genus Lutzomyia , which commonly live in caves, where their main hosts are bats. In the Old World, sand flies in the genus Phlebotomus spread leishmaniasis.
Phlebotomine females, and only females, suck blood from various mammals, reptiles and birds. Some species are selective, whereas others bite any suitable host they find. Some species can produce one clutch of eggs before their first blood meal; such females are said to practise autogenous or partly autogenous reproduction. Other species need a blood meal before they can produce any eggs at all; they are said to practise anautogenous reproduction. As far as is known, all species need a blood meal for every following clutch of eggs. Proteins and other nutrients in the blood they eat enable the female to produce the proteins and fats necessary for them to produce eggs after using up their bodily food stores. [2] In feeding on blood, the flies use their mouthparts to initiate bleeding from the host. They then suck up the exposed blood. Like practically all blood-feeding parasites, they inject biochemicals that inhibit blood clotting, plus some that stimulate host mast cells to produce histamine; this distends capillary vessels, thereby promoting blood flow.
One blood meal can support the production of about 100 eggs. Females lay their eggs in humid soil rich in organic matter. Laboratory colonies of various phlebotomine sand fly species have been established for experimental study. [3]
Sand flies are small; a body size of about 3mm in length is typical for many species, which aids them in escaping notice. Their bite is not always felt, but leaves a small round, reddish bump that starts itching hours or days later. Use of insect repellent is recommended in areas where sand flies are present.
Phlebotomine sand flies can be found between the latitudes 50°N and 40°S, but are absent from New Zealand and the Pacific Islands. [4]
As sand fly females suck blood from vertebrates, including humans, they can transmit leishmaniasis, arboviruses and bartonellosis. [5]
Both sand fly sexes are found to consume plant-derived sugar meals as a source of energy, and certain plants upon which sand flies feed can shorten their life or reduce their capacity for transmitting leishmaniasis. Therefore, the structure of plant communities is found to influence the transmission dynamics of sand fly-borne diseases.
A next-generation sequencing (NGS)–based assay for determining the source of sand fly plant meals, based upon the chloroplast DNA gene ribulose bisphosphate carboxylase large chain ( rbcL ), found that several sand fly species, vectors of leishmaniasis in different parts of the world, prefer feeding on Cannabis sativa . The plant DNA detected in sand flies was from plant cells damaged by their mouthparts as they pierced plant tissues to reach the phloem.
Pollinator insects, including mosquitoes, are attracted to plants that emit volatile molecules such as terpene, and sixty-eight volatile compounds were detected and partially characterized in pollen and vegetative parts of Cannabis sativa by GC-MS. As cannabinoids from C. sativa exhibit antimicrobial activity against some bacteria and fungi, and a potent antileishmanial, and since thriving gut microbiomes are crucial for the development of Leishmania infections in the sand fly gut, a microbicidal effect could harm the infections.
Therefore, a novel approach for controlling blood-sucking mosquitoes and sand flies could be to exploit their plant feeding habit by utilizing attractive toxic sugar baits (ATSBs) that emit olfactory cues to attract the sand flies and mosquitoes through the addition of C. sativa plant extracts, augmenting the efficacy of ATSBs for controlling sugar-questing disease vectors. [5]
Leishmaniasis is a wide array of clinical manifestations caused by parasites of the Trypanosomatida genus Leishmania. It is generally spread through the bite of phlebotomine sandflies, Phlebotomus and Lutzomyia, and occurs most frequently in the tropics and sub-tropics of Africa, Asia, the Americas, and southern Europe. The disease can present in three main ways: cutaneous, mucocutaneous, or visceral. The cutaneous form presents with skin ulcers, while the mucocutaneous form presents with ulcers of the skin, mouth, and nose. The visceral form starts with skin ulcers and later presents with fever, low red blood cell count, and enlarged spleen and liver.
Sandfly or sand fly is a colloquial name for any species or genus of flying, biting, blood-sucking dipteran (fly) encountered in sandy areas. In the United States, sandfly may refer to certain horse flies that are also known as "greenheads", or to members of the family Ceratopogonidae. The bites usually result in a small, intensely itchy bump or welt, the strength of which intensifies over a period of 5-7 days before dissipating. Moderate relief is achieved with varying success through the application of over the counter products such as Benadryl (ingested) or an analgesic cream such as After Bite. Outside the United States, sandfly may refer to members of the subfamily Phlebotominae within the Psychodidae. Biting midges (Ceratopogonidae) are sometimes called sandflies or no-see-ums. New Zealand sandflies are in the genus of sand fly Austrosimulium, a type of black fly.
Lutzomyia is a genus of phlebotomine sand flies consisting of nearly 400 species, at least 33 of which have medical importance as vectors of human disease. Species of the genus Lutzomyia are found only in the New World, distributed in southern areas of the Nearctic and throughout the Neotropical realm. Lutzomyia is one of the two genera of the subfamily Phlebotominae to transmit the Leishmania parasite, with the other being Phlebotomus, found only in the Old World. Lutzomyia sand flies also serve as vectors for the bacterial Carrion's disease and a number of arboviruses.
Phlebotomus is a genus of "sand flies" in the Diptera family Psychodidae. In the past, they have sometimes been considered to belong in a separate family, Phlebotomidae, but this alternative classification has not gained wide acceptance.
Cutaneous leishmaniasis is the most common form of leishmaniasis affecting humans. It is a skin infection caused by a single-celled parasite that is transmitted by the bite of a phlebotomine sand fly. There are about thirty species of Leishmania that may cause cutaneous leishmaniasis.
Ceratopogonidae is a family of flies commonly known as no-see-ums, or biting midges, generally 1–3 millimetres in length. The family includes more than 5,000 species, distributed worldwide, apart from the Antarctic and the Arctic.
Psychodidae, also called drain flies, sink flies, filter flies, sewer flies, or sewer gnats, is a family of true flies. Some genera have short, hairy bodies and wings, giving them a "furry" moth-like appearance, hence one of their common names, moth flies. Members of the sub-family Phlebotominae, which are hematophagous, may be called sand flies in some countries, although this term is also used for other unrelated flies.
Lutzomyia adiketis is an extinct species of sandfly in the moth fly subfamily Phlebotominae. L. adiketis is a vector of the extinct Paleoleishmania neotropicum and both species are solely known from early Miocene Burdigalian stage Dominican amber deposits on the island of Hispaniola.
Pintomyia falcaorum is an extinct species of sandfly in the moth fly subfamily Phlebotominae. P. falcaorum is solely known from early Miocene Burdigalian stage Dominican amber deposits on the island of Hispaniola.
Lutzomyia shannoni is a species of fly in the subfamily Phlebotominae, the phlebotomine sand flies. It is native to the Americas from the southeastern United States to northern Argentina. It has a disjunct distribution, and is only found in regions with suitable climates, habitat types, and host animals. It is well known as a vector of the vesicular stomatitis virus, which causes the disease vesicular stomatitis in animals, particularly livestock.
Lutzomia anthrophora is a species of what is commonly known as the sandfly in the order Diptera and it is a common vector for Leishmania mexicana.
Psathyromyia carpenteri was first described as Phlebotomus carpenteri in 1953. The species name is dedicated to Col. Stanley Jennings Carpenter, M.S.C., U.S. Army, under whose direction most of the first described specimens were collected.
Jean-Antoine Rioux (1925–2017) was a French parasitologist, mainly a specialist of leishmaniasis. He coined the term ecoepidemiology for a discipline combining concepts of ecology and epidemiology to understand parasite transmission patterns and processes. He was a professor at the University of Montpellier, France, and one of the founders of the Société Française de Parasitologie in 1962.
Evandromyia chacuensis is a species of sand fly first circumscribed in 2018 from specimens collected in Argentina. It is the 12th species currently described in the subgenus Barrettomyia.
Lutzomyia longipalpis is a species complex of sandfly belonging to the family Psychodidae. This species is primarily present in Central and South America, but has also appeared in Mexico. There have been reports of L. longipalpis as far south as Argentina, as they are found in a wide variety of ecological conditions. Both males and females feed on sugars from plants and aphids, but only adult females feed on the blood of other mammals. The species has recently begun appearing in urban areas throughout Brazil, and serves as a key vessel for the propagation of the parasite Leishmania infantum. The presence of these flies appears to be strongly correlated to the presence of domestic chickens in Latin America. The first major urban outbreak of the lethal Visceral leishmanias epidemic was detected in Teresina, Piauí State in the early 1980s following a massive planting of acacias.
Maria Cristina Ferro de Carrasquilla (1947–2015) was a Colombian microbiologist and Leishmaniasis researcher who worked for more than forty years at the National Health Institute of Colombia. Most of her research was focused on sandflies, which are Leishmaniasis vectors, contributing with the description of three new species: Lutzomyia torvida, Lutzomyia falcata, and Lutzomyia tolimensis. Given her research contributions, a sandfly species was named after her: Lutzomyia ferroae. Ferro also worked with Venezuelan equine encephalitis virus and received the Emeritus Researcher award from the National Health Institute of Colombia in 2007
Evandromyia is a genus of sand fly first circumscribed in 1941. It is subdivided into three subgenera, which are further subdivided into series.
María Dora Feliciangeli was Professor of Medical Entomology at the University of Carabobo, Venezuela who worked on the transmission of tropical parasites especially American trypanosomiasis and leishmaniasis. She was Coordinator of the National Reference Center of Sandflies and the Medical Entomology Section.
Libanophlebotomus is a genus of fossil sand fly in the subfamily Phlebotominae.
Phlebotomus papatasi is a species of insects commonly known as sandflies. Due to their ectothermic climate limitations, P. papatasi are confined to regions with temperatures above sixty degrees Fahrenheit for at least three months of the year, spanning over much of the European Mediterranean, North Africa, the Middle East, and Central Asia. Around one thousand sandfly species have been described, belonging to the subfamily Phlebotominae within the family Psychodidae. The Psychodidae family belongs to the order Diptera within the class Insecta of the subphylum Hexapoda of the Arthropod phylum.